Obesity and Angiogenesis

Nowadays, high prevalence of obesity and its consequences is considered as a major health complication worldwide. Overweight increases risk of diseases such as hypertension, cardiovascular diseases, type 2 diabetes, certain types of cancer, gallstone, and osteoarthritis. Obesity is defined as growth...

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Main Authors: Zoya Tahergurabi, Majid Khazaei
Format: Article
Language:fas
Published: Isfahan University of Medical Sciences 2012-03-01
Series:مجله دانشکده پزشکی اصفهان
Subjects:
Online Access:http://jims.mui.ac.ir/index.php/jims/article/view/1663
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author Zoya Tahergurabi
Majid Khazaei
author_facet Zoya Tahergurabi
Majid Khazaei
author_sort Zoya Tahergurabi
collection DOAJ
description Nowadays, high prevalence of obesity and its consequences is considered as a major health complication worldwide. Overweight increases risk of diseases such as hypertension, cardiovascular diseases, type 2 diabetes, certain types of cancer, gallstone, and osteoarthritis. Obesity is defined as growth of visceral white adipose tissue. On the other hand, in order to supply for metabolic needs of adipose tissue, depends on appropriate growth of blood vessels, either in number and/or in size (angiogenesis/arteriogenesis). Moreover, the very close interconnection between adipogenesis and angiogenesis has been considered in recent years. Therapeutic interventions for treating obesity by targeting vessels of adipose tissue illustrate a promising future. In this review, we discussed adipose tissue, important roles and functions of vessels in adipose tissue, obesity, and angiogenesis. We finally presented suggestions on how to use anti-angiogenesis agents for treatment of obesity as a novel approach.
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spelling doaj.art-c5bb1972fa584c28808a5556e3aa23542023-09-02T14:42:57ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2012-03-0129172888Obesity and AngiogenesisZoya Tahergurabi0Majid Khazaei1PhD Student, Student Research Committee, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranNowadays, high prevalence of obesity and its consequences is considered as a major health complication worldwide. Overweight increases risk of diseases such as hypertension, cardiovascular diseases, type 2 diabetes, certain types of cancer, gallstone, and osteoarthritis. Obesity is defined as growth of visceral white adipose tissue. On the other hand, in order to supply for metabolic needs of adipose tissue, depends on appropriate growth of blood vessels, either in number and/or in size (angiogenesis/arteriogenesis). Moreover, the very close interconnection between adipogenesis and angiogenesis has been considered in recent years. Therapeutic interventions for treating obesity by targeting vessels of adipose tissue illustrate a promising future. In this review, we discussed adipose tissue, important roles and functions of vessels in adipose tissue, obesity, and angiogenesis. We finally presented suggestions on how to use anti-angiogenesis agents for treatment of obesity as a novel approach.http://jims.mui.ac.ir/index.php/jims/article/view/1663ObesityAngiogenesisAdipogenesis
spellingShingle Zoya Tahergurabi
Majid Khazaei
Obesity and Angiogenesis
مجله دانشکده پزشکی اصفهان
Obesity
Angiogenesis
Adipogenesis
title Obesity and Angiogenesis
title_full Obesity and Angiogenesis
title_fullStr Obesity and Angiogenesis
title_full_unstemmed Obesity and Angiogenesis
title_short Obesity and Angiogenesis
title_sort obesity and angiogenesis
topic Obesity
Angiogenesis
Adipogenesis
url http://jims.mui.ac.ir/index.php/jims/article/view/1663
work_keys_str_mv AT zoyatahergurabi obesityandangiogenesis
AT majidkhazaei obesityandangiogenesis