Preserved circannual rhythm of vitamin D in kidney transplant patients
BACKGROUND: A high prevalence of vitamin D insufficiency has been found in the general population, in patients with chronic kidney disease and in kidney transplant patients. During winter there is a higher prevalence of vitamin D insufficiency due to the lack of solar ultraviolet B (UVB) exposu...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2012-08-01
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| Series: | Swiss Medical Weekly |
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| Online Access: | https://www.smw.ch/index.php/smw/article/view/1574 |
| _version_ | 1811288515420356608 |
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| author | Felix Burkhalter Stefan Schaub Michael Dickenmann |
| author_facet | Felix Burkhalter Stefan Schaub Michael Dickenmann |
| author_sort | Felix Burkhalter |
| collection | DOAJ |
| description |
BACKGROUND: A high prevalence of vitamin D insufficiency has been found in the general population, in patients with chronic kidney disease and in kidney transplant patients. During winter there is a higher prevalence of vitamin D insufficiency due to the lack of solar ultraviolet B (UVB) exposure. Kidney transplant patients are advised to avoid sun exposure because of their high risk of skin cancer. This is considered to be one of the main reasons for the very high prevalence of vitamin D insufficiency in these patients. Whether circannual rhythm of vitamin D is totally reversed in kidney transplant patients is not known.
METHODS: In this single centre prospective observational study, 50 kidney transplant patients visiting our outpatient clinic in January and February 2011 were included. Serum concentration of 25-hydroxvitamin D (25[OH]D), 1-25-hydroxvitamin D (1-25[OH]D) and intact parathormone (iPTH) were measured at study entry and 6 months later in summer.
RESULTS: A total of 90% (45/50) of the study population had vitamin D deficiency 25(OH)D (<50 nmol/l) during winter. There was a rise of 25(OH)D in 94% (47/50) of patients from winter to summer (p <0.0001) leading to a decline of 25(OH)D deficiency from 90 to 60%, to a rise of 25(OH)D insufficiency from 6 to 26% and normal 25(OH)D from 4 to 14%, respectively (p = 0.0024).
CONCLUSIONS: Vitamin D insufficiency during winter is very common in kidney transplant patients at our centre. Despite avoidance of exposure to UVB there is a preserved circannual rhythm of vitamin D in kidney transplant patients.
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| first_indexed | 2024-04-13T03:37:39Z |
| format | Article |
| id | doaj.art-c5bbe37e5f46476783c881f0e5fb872d |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2024-04-13T03:37:39Z |
| publishDate | 2012-08-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-c5bbe37e5f46476783c881f0e5fb872d2022-12-22T03:04:17ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972012-08-01142353610.4414/smw.2012.13672Preserved circannual rhythm of vitamin D in kidney transplant patientsFelix BurkhalterStefan SchaubMichael Dickenmann BACKGROUND: A high prevalence of vitamin D insufficiency has been found in the general population, in patients with chronic kidney disease and in kidney transplant patients. During winter there is a higher prevalence of vitamin D insufficiency due to the lack of solar ultraviolet B (UVB) exposure. Kidney transplant patients are advised to avoid sun exposure because of their high risk of skin cancer. This is considered to be one of the main reasons for the very high prevalence of vitamin D insufficiency in these patients. Whether circannual rhythm of vitamin D is totally reversed in kidney transplant patients is not known. METHODS: In this single centre prospective observational study, 50 kidney transplant patients visiting our outpatient clinic in January and February 2011 were included. Serum concentration of 25-hydroxvitamin D (25[OH]D), 1-25-hydroxvitamin D (1-25[OH]D) and intact parathormone (iPTH) were measured at study entry and 6 months later in summer. RESULTS: A total of 90% (45/50) of the study population had vitamin D deficiency 25(OH)D (<50 nmol/l) during winter. There was a rise of 25(OH)D in 94% (47/50) of patients from winter to summer (p <0.0001) leading to a decline of 25(OH)D deficiency from 90 to 60%, to a rise of 25(OH)D insufficiency from 6 to 26% and normal 25(OH)D from 4 to 14%, respectively (p = 0.0024). CONCLUSIONS: Vitamin D insufficiency during winter is very common in kidney transplant patients at our centre. Despite avoidance of exposure to UVB there is a preserved circannual rhythm of vitamin D in kidney transplant patients. https://www.smw.ch/index.php/smw/article/view/1574kidney transplantationsun exposureVitamin D |
| spellingShingle | Felix Burkhalter Stefan Schaub Michael Dickenmann Preserved circannual rhythm of vitamin D in kidney transplant patients Swiss Medical Weekly kidney transplantation sun exposure Vitamin D |
| title | Preserved circannual rhythm of vitamin D in kidney transplant patients |
| title_full | Preserved circannual rhythm of vitamin D in kidney transplant patients |
| title_fullStr | Preserved circannual rhythm of vitamin D in kidney transplant patients |
| title_full_unstemmed | Preserved circannual rhythm of vitamin D in kidney transplant patients |
| title_short | Preserved circannual rhythm of vitamin D in kidney transplant patients |
| title_sort | preserved circannual rhythm of vitamin d in kidney transplant patients |
| topic | kidney transplantation sun exposure Vitamin D |
| url | https://www.smw.ch/index.php/smw/article/view/1574 |
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