Clinical predictors of response to immunomodulators for multiple sclerosis
OBJECTIVES: To determine, based on clinical criteria, the proportion of multiple sclerosis (MS) patients responsive to immunomodulators (RI) and nonresponsive to immunomodulators (NRI), and to ascertain whether clinical and epidemiological data differs between RI and NRI patient groups. METHODS: Pat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2012-01-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000100004&lng=en&tlng=en |
| _version_ | 1818964074147348480 |
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| author | Guilherme Sciascia do Olival Leonardo Ciciarelli Pereira Lima Gabriel Paiva Silva Lima Charles Peter Tilbery |
| author_facet | Guilherme Sciascia do Olival Leonardo Ciciarelli Pereira Lima Gabriel Paiva Silva Lima Charles Peter Tilbery |
| author_sort | Guilherme Sciascia do Olival |
| collection | DOAJ |
| description | OBJECTIVES: To determine, based on clinical criteria, the proportion of multiple sclerosis (MS) patients responsive to immunomodulators (RI) and nonresponsive to immunomodulators (NRI), and to ascertain whether clinical and epidemiological data differs between RI and NRI patient groups. METHODS: Patients were assessed on rate of exarcerbations per year, for the period before and after commencement of treatment. The RI and NRI groups were compared for several clinical and epidemiological characteristics. DISCUSSION AND CONCLUSION: A total of 31.4% of the patients were nonresponders to the immunomodulatory treatment. The main predictors of immunomodulatory response were early diagnostic and commencement of therapy and high rate of annual exacerbations prior to treatment. Given the arsenal of medication options available for MS management, screening potential candidates for different therapeutic approaches are critical to optimize evolution of patients with the disease. |
| first_indexed | 2024-12-20T12:55:19Z |
| format | Article |
| id | doaj.art-c5c02c8841fd464a8151683f9ec35d69 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-20T12:55:19Z |
| publishDate | 2012-01-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-c5c02c8841fd464a8151683f9ec35d692022-12-21T19:40:04ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272012-01-01701121610.1590/S0004-282X2012000100004S0004-282X2012000100004Clinical predictors of response to immunomodulators for multiple sclerosisGuilherme Sciascia do Olival0Leonardo Ciciarelli Pereira Lima1Gabriel Paiva Silva Lima2Charles Peter Tilbery3Santa Casa de Misericórdia de São PauloSanta Casa de Misericórdia de São PauloSanta Casa de Misericórdia de São PauloSanta Casa de Misericórdia de São PauloOBJECTIVES: To determine, based on clinical criteria, the proportion of multiple sclerosis (MS) patients responsive to immunomodulators (RI) and nonresponsive to immunomodulators (NRI), and to ascertain whether clinical and epidemiological data differs between RI and NRI patient groups. METHODS: Patients were assessed on rate of exarcerbations per year, for the period before and after commencement of treatment. The RI and NRI groups were compared for several clinical and epidemiological characteristics. DISCUSSION AND CONCLUSION: A total of 31.4% of the patients were nonresponders to the immunomodulatory treatment. The main predictors of immunomodulatory response were early diagnostic and commencement of therapy and high rate of annual exacerbations prior to treatment. Given the arsenal of medication options available for MS management, screening potential candidates for different therapeutic approaches are critical to optimize evolution of patients with the disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000100004&lng=en&tlng=enesclerose múltiplaimunomoduladorespreditores |
| spellingShingle | Guilherme Sciascia do Olival Leonardo Ciciarelli Pereira Lima Gabriel Paiva Silva Lima Charles Peter Tilbery Clinical predictors of response to immunomodulators for multiple sclerosis Arquivos de Neuro-Psiquiatria esclerose múltipla imunomoduladores preditores |
| title | Clinical predictors of response to immunomodulators for multiple sclerosis |
| title_full | Clinical predictors of response to immunomodulators for multiple sclerosis |
| title_fullStr | Clinical predictors of response to immunomodulators for multiple sclerosis |
| title_full_unstemmed | Clinical predictors of response to immunomodulators for multiple sclerosis |
| title_short | Clinical predictors of response to immunomodulators for multiple sclerosis |
| title_sort | clinical predictors of response to immunomodulators for multiple sclerosis |
| topic | esclerose múltipla imunomoduladores preditores |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000100004&lng=en&tlng=en |
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