Worldwide productivity and research trend of publications concerning tumor immune microenvironment (TIME): a bibliometric study
Abstract Background As the complexity and diversity of the tumor immune microenvironment (TIME) are becoming better understood, burgeoning research has progressed in this field. However, there is a scarcity of literature specifically focused on the bibliometric analysis of this topic. This study sou...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-07-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01195-3 |
| _version_ | 1797779005905043456 |
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| author | Yao-Ge Liu Shi-Tao Jiang Lei Zhang Han Zheng Ting Zhang Jun-Wei Zhang Hai-Tao Zhao Xin-Ting Sang Yi-Yao Xu Xin Lu |
| author_facet | Yao-Ge Liu Shi-Tao Jiang Lei Zhang Han Zheng Ting Zhang Jun-Wei Zhang Hai-Tao Zhao Xin-Ting Sang Yi-Yao Xu Xin Lu |
| author_sort | Yao-Ge Liu |
| collection | DOAJ |
| description | Abstract Background As the complexity and diversity of the tumor immune microenvironment (TIME) are becoming better understood, burgeoning research has progressed in this field. However, there is a scarcity of literature specifically focused on the bibliometric analysis of this topic. This study sought to investigate the development pattern of TIME-related research from 2006 to September 14, 2022, from a bibliometric perspective. Methods We acquired both articles and reviews related to TIME from the Web of Science Core Collection (WoSCC) (retrieved on September 14, 2022). R package “Bibliometrix” was used to calculate the basic bibliometric features, present the collaborative conditions of countries and authors, and generate a three-field plot to show the relationships among authors, affiliations, and keywords. VOSviewer was utilized for co-authorship analysis of country and institution and keyword co-occurrence analysis. CiteSpace was used for citation burst analysis of keywords and cited references. In addition, Microsoft Office Excel 2019 was used to develop an exponential model to fit the cumulative publication numbers. Results A total of 2545 publications on TIME were included, and the annual publication trend exhibited a significant increase over time. China and Fudan University were the most productive country and institution, with the highest number of publications of 1495 and 396, respectively. Frontiers in Oncology held the highest number of publications. A number of authors were recognized as the main contributors in this field. The clustering analysis revealed six clusters of keywords that highlighted the research hot spots in the fields of basic medical research, immunotherapy, and various cancer types separately. Conclusions This research analyzed 16 years of TIME-related research and sketched out a basic knowledge framework that includes publications, countries, journals, authors, institutions, and keywords. The finding revealed that the current research hot spots of the TIME domain lie in “TIME and cancer prognosis”, “cancer immunotherapy”, and “immune checkpoint”. Our researchers identified the following areas: “immune checkpoint-based immunotherapy”, “precise immunotherapy” and “immunocyte pattern”, which may emerge as frontiers and focal points in the upcoming years, offering valuable avenues for further exploration. |
| first_indexed | 2024-03-12T23:25:32Z |
| format | Article |
| id | doaj.art-c5c0e31984f74a3fa08c90f4fe063531 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-12T23:25:32Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-c5c0e31984f74a3fa08c90f4fe0635312023-07-16T11:13:02ZengBMCEuropean Journal of Medical Research2047-783X2023-07-0128111410.1186/s40001-023-01195-3Worldwide productivity and research trend of publications concerning tumor immune microenvironment (TIME): a bibliometric studyYao-Ge Liu0Shi-Tao Jiang1Lei Zhang2Han Zheng3Ting Zhang4Jun-Wei Zhang5Hai-Tao Zhao6Xin-Ting Sang7Yi-Yao Xu8Xin Lu9Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC)Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC)Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC)Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC)Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC)Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC)Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC)Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC)Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC)Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC)Abstract Background As the complexity and diversity of the tumor immune microenvironment (TIME) are becoming better understood, burgeoning research has progressed in this field. However, there is a scarcity of literature specifically focused on the bibliometric analysis of this topic. This study sought to investigate the development pattern of TIME-related research from 2006 to September 14, 2022, from a bibliometric perspective. Methods We acquired both articles and reviews related to TIME from the Web of Science Core Collection (WoSCC) (retrieved on September 14, 2022). R package “Bibliometrix” was used to calculate the basic bibliometric features, present the collaborative conditions of countries and authors, and generate a three-field plot to show the relationships among authors, affiliations, and keywords. VOSviewer was utilized for co-authorship analysis of country and institution and keyword co-occurrence analysis. CiteSpace was used for citation burst analysis of keywords and cited references. In addition, Microsoft Office Excel 2019 was used to develop an exponential model to fit the cumulative publication numbers. Results A total of 2545 publications on TIME were included, and the annual publication trend exhibited a significant increase over time. China and Fudan University were the most productive country and institution, with the highest number of publications of 1495 and 396, respectively. Frontiers in Oncology held the highest number of publications. A number of authors were recognized as the main contributors in this field. The clustering analysis revealed six clusters of keywords that highlighted the research hot spots in the fields of basic medical research, immunotherapy, and various cancer types separately. Conclusions This research analyzed 16 years of TIME-related research and sketched out a basic knowledge framework that includes publications, countries, journals, authors, institutions, and keywords. The finding revealed that the current research hot spots of the TIME domain lie in “TIME and cancer prognosis”, “cancer immunotherapy”, and “immune checkpoint”. Our researchers identified the following areas: “immune checkpoint-based immunotherapy”, “precise immunotherapy” and “immunocyte pattern”, which may emerge as frontiers and focal points in the upcoming years, offering valuable avenues for further exploration.https://doi.org/10.1186/s40001-023-01195-3Tumor immune microenvironment (TIME)BibliometricsVOSviewerCitespaceFrontiers |
| spellingShingle | Yao-Ge Liu Shi-Tao Jiang Lei Zhang Han Zheng Ting Zhang Jun-Wei Zhang Hai-Tao Zhao Xin-Ting Sang Yi-Yao Xu Xin Lu Worldwide productivity and research trend of publications concerning tumor immune microenvironment (TIME): a bibliometric study European Journal of Medical Research Tumor immune microenvironment (TIME) Bibliometrics VOSviewer Citespace Frontiers |
| title | Worldwide productivity and research trend of publications concerning tumor immune microenvironment (TIME): a bibliometric study |
| title_full | Worldwide productivity and research trend of publications concerning tumor immune microenvironment (TIME): a bibliometric study |
| title_fullStr | Worldwide productivity and research trend of publications concerning tumor immune microenvironment (TIME): a bibliometric study |
| title_full_unstemmed | Worldwide productivity and research trend of publications concerning tumor immune microenvironment (TIME): a bibliometric study |
| title_short | Worldwide productivity and research trend of publications concerning tumor immune microenvironment (TIME): a bibliometric study |
| title_sort | worldwide productivity and research trend of publications concerning tumor immune microenvironment time a bibliometric study |
| topic | Tumor immune microenvironment (TIME) Bibliometrics VOSviewer Citespace Frontiers |
| url | https://doi.org/10.1186/s40001-023-01195-3 |
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