Cell penetrating peptides can exert biological activity: a review
Cell penetrating peptides (CPPs) have been successful in delivering cargo into many different cell types and are an important alternative to other methods of permeation that might damage the integrity of the cell membrane. The traditional view of CPPs is that they are inert molecules that can be suc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2010-08-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc.2010.016 |
| _version_ | 1818731689767075840 |
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| author | Brugnano Jamie Ward Brian C. Panitch Alyssa |
| author_facet | Brugnano Jamie Ward Brian C. Panitch Alyssa |
| author_sort | Brugnano Jamie |
| collection | DOAJ |
| description | Cell penetrating peptides (CPPs) have been successful in delivering cargo into many different cell types and are an important alternative to other methods of permeation that might damage the integrity of the cell membrane. The traditional view of CPPs is that they are inert molecules that can be successfully used to deliver many cargos intracellularly. The goal of this review is to challenge this traditional understanding of CPPs. Recent literature has demonstrated that CPPs themselves can convey biological activity, including the alteration of gene expression and inhibition of protein kinases and proteolytic activity. Further characterization of CPPs is required to determine the extent of this activity. Research into the use of CPPs for intracellular delivery should continue with investigators being aware of these recent results. |
| first_indexed | 2024-12-17T23:21:40Z |
| format | Article |
| id | doaj.art-c5c28f943cf34f8092a096755625211b |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-17T23:21:40Z |
| publishDate | 2010-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-c5c28f943cf34f8092a096755625211b2022-12-21T21:28:52ZengDe GruyterBiomolecular Concepts1868-50211868-503X2010-08-011210911610.1515/bmc.2010.016Cell penetrating peptides can exert biological activity: a reviewBrugnano Jamie0Ward Brian C.Panitch Alyssa1Weldon School of Biomedical Engineering, Purdue University, 206 South Martin Jischke Drive, West Lafayette, IN 47907, USAWeldon School of Biomedical Engineering, Purdue University, 206 South Martin Jischke Drive, West Lafayette, IN 47907, USACell penetrating peptides (CPPs) have been successful in delivering cargo into many different cell types and are an important alternative to other methods of permeation that might damage the integrity of the cell membrane. The traditional view of CPPs is that they are inert molecules that can be successfully used to deliver many cargos intracellularly. The goal of this review is to challenge this traditional understanding of CPPs. Recent literature has demonstrated that CPPs themselves can convey biological activity, including the alteration of gene expression and inhibition of protein kinases and proteolytic activity. Further characterization of CPPs is required to determine the extent of this activity. Research into the use of CPPs for intracellular delivery should continue with investigators being aware of these recent results.https://doi.org/10.1515/bmc.2010.016biological activitycell penetrating peptidesgene expressionprotein kinaseprotein transduction domainsproteolytic activity |
| spellingShingle | Brugnano Jamie Ward Brian C. Panitch Alyssa Cell penetrating peptides can exert biological activity: a review Biomolecular Concepts biological activity cell penetrating peptides gene expression protein kinase protein transduction domains proteolytic activity |
| title | Cell penetrating peptides can exert biological activity: a review |
| title_full | Cell penetrating peptides can exert biological activity: a review |
| title_fullStr | Cell penetrating peptides can exert biological activity: a review |
| title_full_unstemmed | Cell penetrating peptides can exert biological activity: a review |
| title_short | Cell penetrating peptides can exert biological activity: a review |
| title_sort | cell penetrating peptides can exert biological activity a review |
| topic | biological activity cell penetrating peptides gene expression protein kinase protein transduction domains proteolytic activity |
| url | https://doi.org/10.1515/bmc.2010.016 |
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