Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles

Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles

KEAP1 is a cytoplasmic protein that functions as an adaptor for the Cullin-3-based ubiquitin E3 ligase system, which regulates the degradation of many proteins, including NFE2L2/NRF2 and p62/SQSTM1. Loss of KEAP1 leads to an accumulation of protein ubiquitin aggregates and defective autophagy. To be...

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Main Authors: Elisabet Uribe-Carretero, Guadalupe Martinez-Chacón, Sokhna M. S. Yakhine-Diop, Gema Duque-González, Mario Rodríguez-Arribas, Eva Alegre-Cortés, Marta Paredes-Barquero, Saray Canales-Cortés, Elisa Pizarro-Estrella, Antonio Cuadrado, Rosa Ana González-Polo, José M. Fuentes, Mireia Niso-Santano
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antioxidants
Subjects:
autophagy
cathepsin D
endosomes
KEAP1
LAMP1
lysosomes
Online Access:https://www.mdpi.com/2076-3921/11/7/1398

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