Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects
Abstract Acute coronary syndromes, such as myocardial infarction (MI), lack effective therapies beyond heart transplantation, which is often hindered by donor scarcity and postoperative complications. Human induced pluripotent stem cells (hiPSCs) offer the possibility of myocardial regeneration by d...
| Päätekijät: | , , , , , , , , |
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| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
| Julkaistu: |
BMC
2024-10-01
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| Sarja: | Stem Cell Research & Therapy |
| Aiheet: | |
| Linkit: | https://doi.org/10.1186/s13287-024-03961-4 |
| _version_ | 1827068684895518720 |
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| author | Xi Jiang Xin Lian Kun Wei Jie Zhang Kaihua Yu Haoming Li Haichun Ma Yin Cai Lei Pang |
| author_facet | Xi Jiang Xin Lian Kun Wei Jie Zhang Kaihua Yu Haoming Li Haichun Ma Yin Cai Lei Pang |
| author_sort | Xi Jiang |
| collection | DOAJ |
| description | Abstract Acute coronary syndromes, such as myocardial infarction (MI), lack effective therapies beyond heart transplantation, which is often hindered by donor scarcity and postoperative complications. Human induced pluripotent stem cells (hiPSCs) offer the possibility of myocardial regeneration by differentiating into cardiomyocytes. However, hiPSC-derived cardiomyocytes (hiPSC-cardiomyocytes) exhibit fetal-like calcium flux and energy metabolism, which inhibits their engraftment. Several strategies have been explored to improve the therapeutic efficacy of hiPSC-cardiomyocytes, such as selectively enhancing energy substrate utilization and improving the transplantation environment. In this review, we have discussed the impact of altered mitochondrial biogenesis and metabolic switching on the maturation of hiPSC-cardiomyocytes. Additionally, we have discussed the limitations inherent in current methodologies for assessing metabolism in hiPSC-cardiomyocytes, and the challenges in achieving sufficient metabolic flexibility akin to that in the healthy adult heart. |
| first_indexed | 2025-03-19T23:54:39Z |
| format | Article |
| id | doaj.art-c5c3bc1670f4433cb15d4ba6c4c701b4 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2025-03-19T23:54:39Z |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-c5c3bc1670f4433cb15d4ba6c4c701b42024-10-13T11:09:28ZengBMCStem Cell Research & Therapy1757-65122024-10-0115111110.1186/s13287-024-03961-4Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspectsXi Jiang0Xin Lian1Kun Wei2Jie Zhang3Kaihua Yu4Haoming Li5Haichun Ma6Yin Cai7Lei Pang8Health management center, the First Hospital of Jilin UniversityDepartment of Urology, the First Hospital of Jilin UniversityDepartment of Rehabilitation, The Second Affiliated Hospital, Shandong University of Traditional Chinese MedicineDepartment of Anesthesiology, the First Hospital of Jilin UniversityDepartment of Anesthesiology, the First Hospital of Jilin UniversityDepartment of Anesthesiology, the First Hospital of Jilin UniversityDepartment of Anesthesiology, the First Hospital of Jilin UniversityDepartment of Health Technology and Informatics, the Hong Kong Polytechnic UniversityDepartment of Anesthesiology, the First Hospital of Jilin UniversityAbstract Acute coronary syndromes, such as myocardial infarction (MI), lack effective therapies beyond heart transplantation, which is often hindered by donor scarcity and postoperative complications. Human induced pluripotent stem cells (hiPSCs) offer the possibility of myocardial regeneration by differentiating into cardiomyocytes. However, hiPSC-derived cardiomyocytes (hiPSC-cardiomyocytes) exhibit fetal-like calcium flux and energy metabolism, which inhibits their engraftment. Several strategies have been explored to improve the therapeutic efficacy of hiPSC-cardiomyocytes, such as selectively enhancing energy substrate utilization and improving the transplantation environment. In this review, we have discussed the impact of altered mitochondrial biogenesis and metabolic switching on the maturation of hiPSC-cardiomyocytes. Additionally, we have discussed the limitations inherent in current methodologies for assessing metabolism in hiPSC-cardiomyocytes, and the challenges in achieving sufficient metabolic flexibility akin to that in the healthy adult heart.https://doi.org/10.1186/s13287-024-03961-4Acute coronary syndromesMyocardial infarctionInduced pluripotent stem cellsiPSC-cardiomyocytesMaturationEnergy metabolism |
| spellingShingle | Xi Jiang Xin Lian Kun Wei Jie Zhang Kaihua Yu Haoming Li Haichun Ma Yin Cai Lei Pang Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects Stem Cell Research & Therapy Acute coronary syndromes Myocardial infarction Induced pluripotent stem cells iPSC-cardiomyocytes Maturation Energy metabolism |
| title | Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects |
| title_full | Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects |
| title_fullStr | Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects |
| title_full_unstemmed | Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects |
| title_short | Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects |
| title_sort | maturation of pluripotent stem cell derived cardiomyocytes limitations and challenges from metabolic aspects |
| topic | Acute coronary syndromes Myocardial infarction Induced pluripotent stem cells iPSC-cardiomyocytes Maturation Energy metabolism |
| url | https://doi.org/10.1186/s13287-024-03961-4 |
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