The RON Receptor Tyrosine Kinase Promotes Metastasis by Triggering MBD4-Dependent DNA Methylation Reprogramming

The RON Receptor Tyrosine Kinase Promotes Metastasis by Triggering MBD4-Dependent DNA Methylation Reprogramming

Metastasis is the major cause of death in cancer patients, yet the genetic and epigenetic programs that drive metastasis are poorly understood. Here, we report an epigenetic reprogramming pathway that is required for breast cancer metastasis. Concerted differential DNA methylation is initiated by th...

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Bibliographic Details
Main Authors:	Stéphanie Cunha, Yi-Chun Lin, Elizabeth A. Goossen, Christa I. DeVette, Mark R. Albertella, Stuart Thomson, Mark J. Mulvihill, Alana L. Welm
Format:	Article
Language:	English
Published:	Elsevier 2014-01-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124713007559

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