Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'
Previously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
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eLife Sciences Publications Ltd
2023-06-01
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Series: | eLife |
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Online Access: | https://elifesciences.org/articles/85370 |
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author | Yutian Li Anish A Sarma Iris T Lee Fayth Hui Tan Michael J Abrams Zevin J Condiotte Martin Heithe Misha Raffiee John O Dabiri David A Gold Lea Goentoro |
author_facet | Yutian Li Anish A Sarma Iris T Lee Fayth Hui Tan Michael J Abrams Zevin J Condiotte Martin Heithe Misha Raffiee John O Dabiri David A Gold Lea Goentoro |
author_sort | Yutian Li |
collection | DOAJ |
description | Previously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in flies (Sustar and Tuthill, 2023). Here we discuss that differences in the amputation method, treatment concentrations, age of the animals, and stress management explain why they did not observe a regenerative response in flies. Typically, 30–50% of treated flies showed response in our assay. |
first_indexed | 2024-03-13T03:50:11Z |
format | Article |
id | doaj.art-c5c5384718264a2894187168779026a5 |
institution | Directory Open Access Journal |
issn | 2050-084X |
language | English |
last_indexed | 2024-03-13T03:50:11Z |
publishDate | 2023-06-01 |
publisher | eLife Sciences Publications Ltd |
record_format | Article |
series | eLife |
spelling | doaj.art-c5c5384718264a2894187168779026a52023-06-22T15:37:52ZengeLife Sciences Publications LtdeLife2050-084X2023-06-011210.7554/eLife.85370Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'Yutian Li0Anish A Sarma1Iris T Lee2Fayth Hui Tan3Michael J Abrams4Zevin J Condiotte5Martin Heithe6Misha Raffiee7John O Dabiri8David A Gold9Lea Goentoro10https://orcid.org/0000-0002-3904-0195Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesGraduate Aerospace Laboratories and Mechanical Engineering, California Institute of Technology, Pasadena, United StatesGraduate Aerospace Laboratories and Mechanical Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesPreviously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in flies (Sustar and Tuthill, 2023). Here we discuss that differences in the amputation method, treatment concentrations, age of the animals, and stress management explain why they did not observe a regenerative response in flies. Typically, 30–50% of treated flies showed response in our assay.https://elifesciences.org/articles/85370moon jellyfishregenerationinsulinleucineappendage |
spellingShingle | Yutian Li Anish A Sarma Iris T Lee Fayth Hui Tan Michael J Abrams Zevin J Condiotte Martin Heithe Misha Raffiee John O Dabiri David A Gold Lea Goentoro Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' eLife moon jellyfish regeneration insulin leucine appendage |
title | Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' |
title_full | Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' |
title_fullStr | Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' |
title_full_unstemmed | Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' |
title_short | Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice' |
title_sort | response to comment on a conserved strategy for inducing appendage regeneration in moon jellyfish drosophila and mice |
topic | moon jellyfish regeneration insulin leucine appendage |
url | https://elifesciences.org/articles/85370 |
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