Targeting of activated fibroblasts for imaging and therapy
Abstract Tumors form a complex environment consisting of a variety of non-malignant cells. Especially cancer-associated fibroblasts have been shown to have an important role for different aspects of malignant tumors such as migration, metastasis, resistance to chemotherapy and immunosuppression. The...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-07-01
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| Series: | EJNMMI Radiopharmacy and Chemistry |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41181-019-0069-0 |
| _version_ | 1818276601770541056 |
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| author | Thomas Lindner Anastasia Loktev Frederik Giesel Clemens Kratochwil Annette Altmann Uwe Haberkorn |
| author_facet | Thomas Lindner Anastasia Loktev Frederik Giesel Clemens Kratochwil Annette Altmann Uwe Haberkorn |
| author_sort | Thomas Lindner |
| collection | DOAJ |
| description | Abstract Tumors form a complex environment consisting of a variety of non-malignant cells. Especially cancer-associated fibroblasts have been shown to have an important role for different aspects of malignant tumors such as migration, metastasis, resistance to chemotherapy and immunosuppression. Therefore, a targeting of these cells may be useful for both imaging and therapy. In this respect, an interesting target is the fibroblast activation protein (FAP) which is expressed in activated fibroblasts, but not in quiescent fibroblasts, giving the opportunity to use this membrane-anchored enzyme as a target for radionuclide-based approaches for diagnosis and treatment of tumors and for the diagnosis of non-malignant disease associated with a remodelling of the extracellular matrix. |
| first_indexed | 2024-12-12T22:48:15Z |
| format | Article |
| id | doaj.art-c5c57423a62d47ebb104384eb87ca97d |
| institution | Directory Open Access Journal |
| issn | 2365-421X |
| language | English |
| last_indexed | 2024-12-12T22:48:15Z |
| publishDate | 2019-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Radiopharmacy and Chemistry |
| spelling | doaj.art-c5c57423a62d47ebb104384eb87ca97d2022-12-22T00:09:08ZengSpringerOpenEJNMMI Radiopharmacy and Chemistry2365-421X2019-07-014111510.1186/s41181-019-0069-0Targeting of activated fibroblasts for imaging and therapyThomas Lindner0Anastasia Loktev1Frederik Giesel2Clemens Kratochwil3Annette Altmann4Uwe Haberkorn5Department of Nuclear Medicine, University Hospital HeidelbergDepartment of Nuclear Medicine, University Hospital HeidelbergDepartment of Nuclear Medicine, University Hospital HeidelbergDepartment of Nuclear Medicine, University Hospital HeidelbergDepartment of Nuclear Medicine, University Hospital HeidelbergDepartment of Nuclear Medicine, University Hospital HeidelbergAbstract Tumors form a complex environment consisting of a variety of non-malignant cells. Especially cancer-associated fibroblasts have been shown to have an important role for different aspects of malignant tumors such as migration, metastasis, resistance to chemotherapy and immunosuppression. Therefore, a targeting of these cells may be useful for both imaging and therapy. In this respect, an interesting target is the fibroblast activation protein (FAP) which is expressed in activated fibroblasts, but not in quiescent fibroblasts, giving the opportunity to use this membrane-anchored enzyme as a target for radionuclide-based approaches for diagnosis and treatment of tumors and for the diagnosis of non-malignant disease associated with a remodelling of the extracellular matrix.http://link.springer.com/article/10.1186/s41181-019-0069-0Cancer-associated fibroblastTumor stromaFibroblast activation proteinInhibitorsImaging |
| spellingShingle | Thomas Lindner Anastasia Loktev Frederik Giesel Clemens Kratochwil Annette Altmann Uwe Haberkorn Targeting of activated fibroblasts for imaging and therapy EJNMMI Radiopharmacy and Chemistry Cancer-associated fibroblast Tumor stroma Fibroblast activation protein Inhibitors Imaging |
| title | Targeting of activated fibroblasts for imaging and therapy |
| title_full | Targeting of activated fibroblasts for imaging and therapy |
| title_fullStr | Targeting of activated fibroblasts for imaging and therapy |
| title_full_unstemmed | Targeting of activated fibroblasts for imaging and therapy |
| title_short | Targeting of activated fibroblasts for imaging and therapy |
| title_sort | targeting of activated fibroblasts for imaging and therapy |
| topic | Cancer-associated fibroblast Tumor stroma Fibroblast activation protein Inhibitors Imaging |
| url | http://link.springer.com/article/10.1186/s41181-019-0069-0 |
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