Cardio-protective effects of phytosterol-enriched functional black tea in mild hypercholesterolemia subjects
Hypercholesterolemia is a common condition in which the risk for the development of cardiovascular disease (CVD) is increased. Due to their hypocholesterolemic effects, phytosterols are considered to be effective in the prevention of CVD, particularly coronary heart disease. The aim of study was to...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617300622 |
| _version_ | 1818953860435148800 |
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| author | Asım Orem Cesarettin Alasalvar Birgül Vanizor Kural Serap Yaman Cihan Orem Ayse Karadag Ebru Pelvan Jerzy Zawistowski |
| author_facet | Asım Orem Cesarettin Alasalvar Birgül Vanizor Kural Serap Yaman Cihan Orem Ayse Karadag Ebru Pelvan Jerzy Zawistowski |
| author_sort | Asım Orem |
| collection | DOAJ |
| description | Hypercholesterolemia is a common condition in which the risk for the development of cardiovascular disease (CVD) is increased. Due to their hypocholesterolemic effects, phytosterols are considered to be effective in the prevention of CVD, particularly coronary heart disease. The aim of study was to investigate the cardio-protective effects of phytosterol-enriched instant black tea (functional black tea) in subjects with mild hypercholesterolemia. A randomized, double-blind, and placebo-controlled study was conducted on volunteer subjects aged 25–60 y with mild hypercholesterolemia [plasma total cholesterol concentrations 200–239 mg/dL (5.2–6.2 mmol/L)]. Subjects were randomly divided into placebo (PBO) (n = 33; M/F, 23/10), instant black tea (IBT) (n = 34; M/F, 25/9), and functional black tea (FBT) (2 g phytosterols/d) (n = 32; M/F, 24/8) groups and intervention period was conducted for 4 wk. Compared with baseline, consumption of FBT significantly decreased the concentrations of total cholesterol by 5.6% (P < 0.001), low-density lipoprotein (LDL) cholesterol by 8.7% (P < 0.001), apolipoprotein B (P < 0.05), and oxidative stress index (P < 0.05), while increasing the concentrations of adiponectin, total antioxidant status, and tissue-plasminogen activator (P < 0.05). FBT was superior to IBT in terms of cardiovascular risk biomarkers. The data indicate that consumption of newly developed FBT is an excellent beverage for delivering phytosterols and has several beneficial cardio-protective effects in subjects with mild hypercholesterolemia. |
| first_indexed | 2024-12-20T10:12:59Z |
| format | Article |
| id | doaj.art-c5c7c2b55cd84edf892ccb25f03d214d |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T10:12:59Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-c5c7c2b55cd84edf892ccb25f03d214d2022-12-21T19:44:07ZengElsevierJournal of Functional Foods1756-46462017-04-0131311319Cardio-protective effects of phytosterol-enriched functional black tea in mild hypercholesterolemia subjectsAsım Orem0Cesarettin Alasalvar1Birgül Vanizor Kural2Serap Yaman3Cihan Orem4Ayse Karadag5Ebru Pelvan6Jerzy Zawistowski7Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeyTÜBİTAK Marmara Research Center, Food Institute, Gebze-Kocaeli, Turkey; Corresponding author at: TÜBİTAK Marmara Research Center, Food Institute, Gebze-Kocaeli, Turkey.Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeyDepartment of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeyDepartment of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeyTÜBİTAK Marmara Research Center, Food Institute, Gebze-Kocaeli, TurkeyTÜBİTAK Marmara Research Center, Food Institute, Gebze-Kocaeli, TurkeyFood, Nutrition, and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, CanadaHypercholesterolemia is a common condition in which the risk for the development of cardiovascular disease (CVD) is increased. Due to their hypocholesterolemic effects, phytosterols are considered to be effective in the prevention of CVD, particularly coronary heart disease. The aim of study was to investigate the cardio-protective effects of phytosterol-enriched instant black tea (functional black tea) in subjects with mild hypercholesterolemia. A randomized, double-blind, and placebo-controlled study was conducted on volunteer subjects aged 25–60 y with mild hypercholesterolemia [plasma total cholesterol concentrations 200–239 mg/dL (5.2–6.2 mmol/L)]. Subjects were randomly divided into placebo (PBO) (n = 33; M/F, 23/10), instant black tea (IBT) (n = 34; M/F, 25/9), and functional black tea (FBT) (2 g phytosterols/d) (n = 32; M/F, 24/8) groups and intervention period was conducted for 4 wk. Compared with baseline, consumption of FBT significantly decreased the concentrations of total cholesterol by 5.6% (P < 0.001), low-density lipoprotein (LDL) cholesterol by 8.7% (P < 0.001), apolipoprotein B (P < 0.05), and oxidative stress index (P < 0.05), while increasing the concentrations of adiponectin, total antioxidant status, and tissue-plasminogen activator (P < 0.05). FBT was superior to IBT in terms of cardiovascular risk biomarkers. The data indicate that consumption of newly developed FBT is an excellent beverage for delivering phytosterols and has several beneficial cardio-protective effects in subjects with mild hypercholesterolemia.http://www.sciencedirect.com/science/article/pii/S1756464617300622Phytosterol-enriched dietInstant black teaFunctional drinksCholesterolHypercholesterolemiaAntioxidant |
| spellingShingle | Asım Orem Cesarettin Alasalvar Birgül Vanizor Kural Serap Yaman Cihan Orem Ayse Karadag Ebru Pelvan Jerzy Zawistowski Cardio-protective effects of phytosterol-enriched functional black tea in mild hypercholesterolemia subjects Journal of Functional Foods Phytosterol-enriched diet Instant black tea Functional drinks Cholesterol Hypercholesterolemia Antioxidant |
| title | Cardio-protective effects of phytosterol-enriched functional black tea in mild hypercholesterolemia subjects |
| title_full | Cardio-protective effects of phytosterol-enriched functional black tea in mild hypercholesterolemia subjects |
| title_fullStr | Cardio-protective effects of phytosterol-enriched functional black tea in mild hypercholesterolemia subjects |
| title_full_unstemmed | Cardio-protective effects of phytosterol-enriched functional black tea in mild hypercholesterolemia subjects |
| title_short | Cardio-protective effects of phytosterol-enriched functional black tea in mild hypercholesterolemia subjects |
| title_sort | cardio protective effects of phytosterol enriched functional black tea in mild hypercholesterolemia subjects |
| topic | Phytosterol-enriched diet Instant black tea Functional drinks Cholesterol Hypercholesterolemia Antioxidant |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617300622 |
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