Novel case report of primary osteosarcoma of the maxilla in an adult: An important differential diagnosis
Craniofacial osteosarcoma accounts for 10% of osteosarcoma malignancies, typically affecting the 4-5th decade of life, with the maxilla being the second-most common site.We report a 58-year-old male, non-smoker, with a lump of his upper jaw which occasionally bled during mastication. Clinical examin...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
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| Series: | Advances in Oral and Maxillofacial Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667147623000353 |
| _version_ | 1797762748357017600 |
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| author | Meena Venkatasami Katherine Harrison |
| author_facet | Meena Venkatasami Katherine Harrison |
| author_sort | Meena Venkatasami |
| collection | DOAJ |
| description | Craniofacial osteosarcoma accounts for 10% of osteosarcoma malignancies, typically affecting the 4-5th decade of life, with the maxilla being the second-most common site.We report a 58-year-old male, non-smoker, with a lump of his upper jaw which occasionally bled during mastication. Clinical examination revealed an exophytic mass in the upper left tuberosity of the maxilla and no lymphadenopathy, where initial differential diagnosis was squamous cell carcinoma.Radiological investigations revealed a metabolically active left maxillary lesion with maxillary sinus destruction, representing primary malignancy. Histological analyses initially suggested a fibro-osseous lesion; further immunohistochemistry showed cytokeratin AE1/AE3/CK(MNF.116) positivity with 60% ki67 proliferation index; diagnostic of grade 2–3 osteosarcoma. Management included neoadjuvant chemotherapy prior to total maxillectomy and dental prosthetic rehabilitation.We report a novel case of primary osteosarcoma of the maxilla in an adult. Osteosarcoma is challenging to diagnose and an important differential to consider where the mainstay of treatment is early invention. |
| first_indexed | 2024-03-12T19:32:54Z |
| format | Article |
| id | doaj.art-c5c7ed79f04040a99601e25176b1ba47 |
| institution | Directory Open Access Journal |
| issn | 2667-1476 |
| language | English |
| last_indexed | 2024-03-12T19:32:54Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Oral and Maxillofacial Surgery |
| spelling | doaj.art-c5c7ed79f04040a99601e25176b1ba472023-08-02T04:25:13ZengElsevierAdvances in Oral and Maxillofacial Surgery2667-14762023-09-0111100423Novel case report of primary osteosarcoma of the maxilla in an adult: An important differential diagnosisMeena Venkatasami0Katherine Harrison1Corresponding author. St George's hospital, Blackshaw Road, Tooting, London, SW17 0QT, United Kingdom.; Department of Pathology, Royal Shrewsbury Hospital, Shrewsbury, SY3 8XQ, United KingdomDepartment of Pathology, Royal Shrewsbury Hospital, Shrewsbury, SY3 8XQ, United KingdomCraniofacial osteosarcoma accounts for 10% of osteosarcoma malignancies, typically affecting the 4-5th decade of life, with the maxilla being the second-most common site.We report a 58-year-old male, non-smoker, with a lump of his upper jaw which occasionally bled during mastication. Clinical examination revealed an exophytic mass in the upper left tuberosity of the maxilla and no lymphadenopathy, where initial differential diagnosis was squamous cell carcinoma.Radiological investigations revealed a metabolically active left maxillary lesion with maxillary sinus destruction, representing primary malignancy. Histological analyses initially suggested a fibro-osseous lesion; further immunohistochemistry showed cytokeratin AE1/AE3/CK(MNF.116) positivity with 60% ki67 proliferation index; diagnostic of grade 2–3 osteosarcoma. Management included neoadjuvant chemotherapy prior to total maxillectomy and dental prosthetic rehabilitation.We report a novel case of primary osteosarcoma of the maxilla in an adult. Osteosarcoma is challenging to diagnose and an important differential to consider where the mainstay of treatment is early invention.http://www.sciencedirect.com/science/article/pii/S2667147623000353Osteosarcoma of maxillaCranial osteosarcomaPrimary osteosarcomaMaxillaAdultBone tumour |
| spellingShingle | Meena Venkatasami Katherine Harrison Novel case report of primary osteosarcoma of the maxilla in an adult: An important differential diagnosis Advances in Oral and Maxillofacial Surgery Osteosarcoma of maxilla Cranial osteosarcoma Primary osteosarcoma Maxilla Adult Bone tumour |
| title | Novel case report of primary osteosarcoma of the maxilla in an adult: An important differential diagnosis |
| title_full | Novel case report of primary osteosarcoma of the maxilla in an adult: An important differential diagnosis |
| title_fullStr | Novel case report of primary osteosarcoma of the maxilla in an adult: An important differential diagnosis |
| title_full_unstemmed | Novel case report of primary osteosarcoma of the maxilla in an adult: An important differential diagnosis |
| title_short | Novel case report of primary osteosarcoma of the maxilla in an adult: An important differential diagnosis |
| title_sort | novel case report of primary osteosarcoma of the maxilla in an adult an important differential diagnosis |
| topic | Osteosarcoma of maxilla Cranial osteosarcoma Primary osteosarcoma Maxilla Adult Bone tumour |
| url | http://www.sciencedirect.com/science/article/pii/S2667147623000353 |
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