New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa. Environmental factors, genetics, intestinal microbiota, and the immune system are all involved in the pathophysiology of IBD. Lately, accumulating evidence has shown that abnormal epigenetic changes in DNA meth...
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| Format: | Article |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.813659/full |
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| author | Jing Xu Hao-ming Xu Mei-feng Yang Yu-jie Liang Quan-zhou Peng Yuan Zhang Cheng-mei Tian Li-sheng Wang Jun Yao Yu-qiang Nie De-feng Li |
| author_facet | Jing Xu Hao-ming Xu Mei-feng Yang Yu-jie Liang Quan-zhou Peng Yuan Zhang Cheng-mei Tian Li-sheng Wang Jun Yao Yu-qiang Nie De-feng Li |
| author_sort | Jing Xu |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa. Environmental factors, genetics, intestinal microbiota, and the immune system are all involved in the pathophysiology of IBD. Lately, accumulating evidence has shown that abnormal epigenetic changes in DNA methylation, histone markers, and non-coding RNA expression greatly contribute to the development of the entire disease. Epigenetics regulates many functions, such as maintaining the homeostasis of the intestinal epithelium and regulating the immune system of the immune cells. In the present study, we systematically summarized the latest advances in epigenetic modification of IBD and how epigenetics reveals new mechanisms of IBD. Our present review provided new insights into the pathophysiology of IBD. Moreover, exploring the patterns of DNA methylation and histone modification through epigenetics can not only be used as biomarkers of IBD but also as a new target for therapeutic intervention in IBD patients. |
| first_indexed | 2024-12-20T06:21:42Z |
| format | Article |
| id | doaj.art-c5c82195e4494d6a8bad9bdce95c42ff |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T06:21:42Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c5c82195e4494d6a8bad9bdce95c42ff2022-12-21T19:50:23ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-01-011310.3389/fphar.2022.813659813659New Insights Into the Epigenetic Regulation of Inflammatory Bowel DiseaseJing Xu0Hao-ming Xu1Mei-feng Yang2Yu-jie Liang3Quan-zhou Peng4Yuan Zhang5Cheng-mei Tian6Li-sheng Wang7Jun Yao8Yu-qiang Nie9De-feng Li10Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Hematology, Yantian District People’s Hospital, Shenzhen, ChinaShenzhen Kangning Hospital, Shenzhen, ChinaDepartment of Pathology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaDepartment of Medical Administration, Huizhou Institute of Occupational Diseases Control and Prevention, Huizhou, ChinaDepartment of Emergency, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaDepartment of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaDepartment of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaInflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa. Environmental factors, genetics, intestinal microbiota, and the immune system are all involved in the pathophysiology of IBD. Lately, accumulating evidence has shown that abnormal epigenetic changes in DNA methylation, histone markers, and non-coding RNA expression greatly contribute to the development of the entire disease. Epigenetics regulates many functions, such as maintaining the homeostasis of the intestinal epithelium and regulating the immune system of the immune cells. In the present study, we systematically summarized the latest advances in epigenetic modification of IBD and how epigenetics reveals new mechanisms of IBD. Our present review provided new insights into the pathophysiology of IBD. Moreover, exploring the patterns of DNA methylation and histone modification through epigenetics can not only be used as biomarkers of IBD but also as a new target for therapeutic intervention in IBD patients.https://www.frontiersin.org/articles/10.3389/fphar.2022.813659/fullinflammatory bowel diseaseepigeneticsinflammatoryDNA methylationhistone modificationsmiRNA |
| spellingShingle | Jing Xu Hao-ming Xu Mei-feng Yang Yu-jie Liang Quan-zhou Peng Yuan Zhang Cheng-mei Tian Li-sheng Wang Jun Yao Yu-qiang Nie De-feng Li New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease Frontiers in Pharmacology inflammatory bowel disease epigenetics inflammatory DNA methylation histone modifications miRNA |
| title | New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease |
| title_full | New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease |
| title_fullStr | New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease |
| title_full_unstemmed | New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease |
| title_short | New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease |
| title_sort | new insights into the epigenetic regulation of inflammatory bowel disease |
| topic | inflammatory bowel disease epigenetics inflammatory DNA methylation histone modifications miRNA |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.813659/full |
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