Sources, Transformations, Syntheses, and Bioactivities of Monoterpene Pyridine Alkaloids and Cyclopenta[c]pyridine Derivatives
Monoterpene pyridine alkaloids (MTPAs) are alkaloids derived from iridoid glycosides (IGs). The common molecular structure of MTPAs is the pyridine ring, while some of them have a cyclopenta[c]pyridine skeleton. Some compounds containing this structure are potentially bioactive medicinal agents. In...
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/21/7187 |
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| author | Xuejian Zhang Feiyan Tao Tao Cui Cheng Luo Zhigang Zhou Yuchuan Huang Lanlan Tan Wei Peng Chunjie Wu |
| author_facet | Xuejian Zhang Feiyan Tao Tao Cui Cheng Luo Zhigang Zhou Yuchuan Huang Lanlan Tan Wei Peng Chunjie Wu |
| author_sort | Xuejian Zhang |
| collection | DOAJ |
| description | Monoterpene pyridine alkaloids (MTPAs) are alkaloids derived from iridoid glycosides (IGs). The common molecular structure of MTPAs is the pyridine ring, while some of them have a cyclopenta[c]pyridine skeleton. Some compounds containing this structure are potentially bioactive medicinal agents. In this paper, seven drug candidates (<b>A</b>–<b>G</b>), ninety natural source products (<b>1</b>–<b>90</b>), thirty-seven synthesized compounds (<b>91</b>–<b>127</b>), as well as twenty-six key intermediates (<b>S1</b>–<b>S26</b>) were summarized. We categorized five types of MTPAs and one type of cyclopenta[c]pyridine alkaloids in all. Additionally, their possible genetic pathways were proposed. Then, the chemical transformation, biotransformation, chemical synthesis, as well as the bioactivity of MTPAs and cyclopenta[c]pyridine derivatives were analyzed and summarized. Cyclopenta[c]pyridine derivatives can be concisely and chirally synthesized, and they have shown potentials with antibacterial, insecticidal, antiviral, anti-inflammatory, and neuropharmacological activities. |
| first_indexed | 2024-03-09T18:49:18Z |
| format | Article |
| id | doaj.art-c5c88d2f3e7e4a4cb2fb23fc6dd0fbe3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:49:18Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c5c88d2f3e7e4a4cb2fb23fc6dd0fbe32023-11-24T06:00:03ZengMDPI AGMolecules1420-30492022-10-012721718710.3390/molecules27217187Sources, Transformations, Syntheses, and Bioactivities of Monoterpene Pyridine Alkaloids and Cyclopenta[c]pyridine DerivativesXuejian Zhang0Feiyan Tao1Tao Cui2Cheng Luo3Zhigang Zhou4Yuchuan Huang5Lanlan Tan6Wei Peng7Chunjie Wu8Research and Development Centre, China Tobacco Sichuan Industrial Co., Ltd., Chengdu 610066, ChinaResearch and Development Centre, China Tobacco Sichuan Industrial Co., Ltd., Chengdu 610066, ChinaResearch and Development Centre, China Tobacco Sichuan Industrial Co., Ltd., Chengdu 610066, ChinaResearch and Development Centre, China Tobacco Sichuan Industrial Co., Ltd., Chengdu 610066, ChinaResearch and Development Centre, China Tobacco Sichuan Industrial Co., Ltd., Chengdu 610066, ChinaResearch and Development Centre, China Tobacco Sichuan Industrial Co., Ltd., Chengdu 610066, ChinaResearch and Development Centre, China Tobacco Sichuan Industrial Co., Ltd., Chengdu 610066, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaMonoterpene pyridine alkaloids (MTPAs) are alkaloids derived from iridoid glycosides (IGs). The common molecular structure of MTPAs is the pyridine ring, while some of them have a cyclopenta[c]pyridine skeleton. Some compounds containing this structure are potentially bioactive medicinal agents. In this paper, seven drug candidates (<b>A</b>–<b>G</b>), ninety natural source products (<b>1</b>–<b>90</b>), thirty-seven synthesized compounds (<b>91</b>–<b>127</b>), as well as twenty-six key intermediates (<b>S1</b>–<b>S26</b>) were summarized. We categorized five types of MTPAs and one type of cyclopenta[c]pyridine alkaloids in all. Additionally, their possible genetic pathways were proposed. Then, the chemical transformation, biotransformation, chemical synthesis, as well as the bioactivity of MTPAs and cyclopenta[c]pyridine derivatives were analyzed and summarized. Cyclopenta[c]pyridine derivatives can be concisely and chirally synthesized, and they have shown potentials with antibacterial, insecticidal, antiviral, anti-inflammatory, and neuropharmacological activities.https://www.mdpi.com/1420-3049/27/21/7187monoterpene pyridine alkaloidscyclopenta[c]pyridine derivativessourcetransformationsynthesisbioactivity |
| spellingShingle | Xuejian Zhang Feiyan Tao Tao Cui Cheng Luo Zhigang Zhou Yuchuan Huang Lanlan Tan Wei Peng Chunjie Wu Sources, Transformations, Syntheses, and Bioactivities of Monoterpene Pyridine Alkaloids and Cyclopenta[c]pyridine Derivatives Molecules monoterpene pyridine alkaloids cyclopenta[c]pyridine derivatives source transformation synthesis bioactivity |
| title | Sources, Transformations, Syntheses, and Bioactivities of Monoterpene Pyridine Alkaloids and Cyclopenta[c]pyridine Derivatives |
| title_full | Sources, Transformations, Syntheses, and Bioactivities of Monoterpene Pyridine Alkaloids and Cyclopenta[c]pyridine Derivatives |
| title_fullStr | Sources, Transformations, Syntheses, and Bioactivities of Monoterpene Pyridine Alkaloids and Cyclopenta[c]pyridine Derivatives |
| title_full_unstemmed | Sources, Transformations, Syntheses, and Bioactivities of Monoterpene Pyridine Alkaloids and Cyclopenta[c]pyridine Derivatives |
| title_short | Sources, Transformations, Syntheses, and Bioactivities of Monoterpene Pyridine Alkaloids and Cyclopenta[c]pyridine Derivatives |
| title_sort | sources transformations syntheses and bioactivities of monoterpene pyridine alkaloids and cyclopenta c pyridine derivatives |
| topic | monoterpene pyridine alkaloids cyclopenta[c]pyridine derivatives source transformation synthesis bioactivity |
| url | https://www.mdpi.com/1420-3049/27/21/7187 |
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