Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh
Background: Prenatal exposures to neurotoxic metals and trace elements are associated with early childhood neurodevelopmental outcomes. However, consequences of simultaneous exposure to mixtures of elements remain unclear. Objective: To examine individual and joint effects of prenatal trace element...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022002975 |
| _version_ | 1818109261662650368 |
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| author | Liangmin Wei Hui Huang Xin Chen Xiang Wang Ruyang Zhang Li Su Weiwei Duan Mahmudur Rahman Md Golam Mostofa Quazi Qamruzzaman Hongbing Shen Zhibin Hu Yongyue Wei David C. Christiani Feng Chen |
| author_facet | Liangmin Wei Hui Huang Xin Chen Xiang Wang Ruyang Zhang Li Su Weiwei Duan Mahmudur Rahman Md Golam Mostofa Quazi Qamruzzaman Hongbing Shen Zhibin Hu Yongyue Wei David C. Christiani Feng Chen |
| author_sort | Liangmin Wei |
| collection | DOAJ |
| description | Background: Prenatal exposures to neurotoxic metals and trace elements are associated with early childhood neurodevelopmental outcomes. However, consequences of simultaneous exposure to mixtures of elements remain unclear. Objective: To examine individual and joint effects of prenatal trace element exposure on early childhood neurodevelopment. Methods: Using a well-established Bangladesh prospective birth cohort (2008–2011), we measured concentrations of 52 trace elements in umbilical cord serum of 569 mother–infant pairs using inductively coupled plasma mass spectrometry. Neurodevelopment was evaluated at 20–40 months of age using Bayley Scales of Infant and Toddler Development, Third Edition. Stability elastic net (ENET) was used to screen elements individually associated with the outcome; candidate exposures were combined by weighted linear combination to form a risk score representing their mixture effect on early childhood neurodevelopment. Results: Stability ENET identified 15 trace elements associated with cognitive composite score and 14 associated with motor composite score, which were linearly combined to form the element risk score (ERS). Children with higher ERScognitive had lower probability of cognitive developmental delay (ORhighest vs lowest: 0.21; 95 %CI: 0.10, 0.40; P < 0.001; Ptrend < 0.001). Children with ERSmotor in the top quintile had a significantly lower risk of motor developmental delay (OR: 0.16; 95 %CI: 0.09, 0.31; P < 0.001; Ptrend < 0.001) versus the lowest quintile. In Bayesian kernel machine regression analyses, lithium [conditional posterior inclusion probability (cPIP) = 0.68], aluminum (cPIP = 0.83) and iron (cPIP = 1.00) contributed most to the lower cognitive composite score; zinc (cPIP = 1.00), silver (cPIP = 0.81), and antimony (cPIP = 0.65) mainly contributed to the change of motor composite score. Conclusion: Co-exposure to lithium/aluminum/iron or zinc/silver/antimony appears to impact children’s neurodevelopment. ERS score reflecting maternal exposure could indicate children’s risk of neurodevelopmental delay, warranting further studies to explore the underlying mechanism. |
| first_indexed | 2024-12-11T02:28:27Z |
| format | Article |
| id | doaj.art-c5c8be51589c4bb8addd3a9ac3f98edf |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-11T02:28:27Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-c5c8be51589c4bb8addd3a9ac3f98edf2022-12-22T01:23:53ZengElsevierEnvironment International0160-41202022-08-01166107370Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural BangladeshLiangmin Wei0Hui Huang1Xin Chen2Xiang Wang3Ruyang Zhang4Li Su5Weiwei Duan6Mahmudur Rahman7Md Golam Mostofa8Quazi Qamruzzaman9Hongbing Shen10Zhibin Hu11Yongyue Wei12David C. Christiani13Feng Chen14Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USADepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDhaka Community Hospital Trust, Dhaka, BangladeshDhaka Community Hospital Trust, Dhaka, BangladeshDhaka Community Hospital Trust, Dhaka, BangladeshState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; China International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; China International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China; China International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, China; Corresponding authors at: 101 Longmian Avenue, Nanjing 211166, China (Y. Wei and F. Chen) Building I Room 1401, 677 Huntington Avenue, Boston, MA 02115, USA (D.C. Christiani).Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; China International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, China; Corresponding authors at: 101 Longmian Avenue, Nanjing 211166, China (Y. Wei and F. Chen) Building I Room 1401, 677 Huntington Avenue, Boston, MA 02115, USA (D.C. Christiani).State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China; China International Cooperation Center for Environment and Human Health, Center of Global Health, Nanjing Medical University, Nanjing 211166, China; Corresponding authors at: 101 Longmian Avenue, Nanjing 211166, China (Y. Wei and F. Chen) Building I Room 1401, 677 Huntington Avenue, Boston, MA 02115, USA (D.C. Christiani).Background: Prenatal exposures to neurotoxic metals and trace elements are associated with early childhood neurodevelopmental outcomes. However, consequences of simultaneous exposure to mixtures of elements remain unclear. Objective: To examine individual and joint effects of prenatal trace element exposure on early childhood neurodevelopment. Methods: Using a well-established Bangladesh prospective birth cohort (2008–2011), we measured concentrations of 52 trace elements in umbilical cord serum of 569 mother–infant pairs using inductively coupled plasma mass spectrometry. Neurodevelopment was evaluated at 20–40 months of age using Bayley Scales of Infant and Toddler Development, Third Edition. Stability elastic net (ENET) was used to screen elements individually associated with the outcome; candidate exposures were combined by weighted linear combination to form a risk score representing their mixture effect on early childhood neurodevelopment. Results: Stability ENET identified 15 trace elements associated with cognitive composite score and 14 associated with motor composite score, which were linearly combined to form the element risk score (ERS). Children with higher ERScognitive had lower probability of cognitive developmental delay (ORhighest vs lowest: 0.21; 95 %CI: 0.10, 0.40; P < 0.001; Ptrend < 0.001). Children with ERSmotor in the top quintile had a significantly lower risk of motor developmental delay (OR: 0.16; 95 %CI: 0.09, 0.31; P < 0.001; Ptrend < 0.001) versus the lowest quintile. In Bayesian kernel machine regression analyses, lithium [conditional posterior inclusion probability (cPIP) = 0.68], aluminum (cPIP = 0.83) and iron (cPIP = 1.00) contributed most to the lower cognitive composite score; zinc (cPIP = 1.00), silver (cPIP = 0.81), and antimony (cPIP = 0.65) mainly contributed to the change of motor composite score. Conclusion: Co-exposure to lithium/aluminum/iron or zinc/silver/antimony appears to impact children’s neurodevelopment. ERS score reflecting maternal exposure could indicate children’s risk of neurodevelopmental delay, warranting further studies to explore the underlying mechanism.http://www.sciencedirect.com/science/article/pii/S0160412022002975Umbilical cord serumElementomicsEarly childhood neurodevelopmentBangladesh |
| spellingShingle | Liangmin Wei Hui Huang Xin Chen Xiang Wang Ruyang Zhang Li Su Weiwei Duan Mahmudur Rahman Md Golam Mostofa Quazi Qamruzzaman Hongbing Shen Zhibin Hu Yongyue Wei David C. Christiani Feng Chen Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh Environment International Umbilical cord serum Elementomics Early childhood neurodevelopment Bangladesh |
| title | Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh |
| title_full | Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh |
| title_fullStr | Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh |
| title_full_unstemmed | Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh |
| title_short | Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh |
| title_sort | umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment evidence from a prospective birth cohort in rural bangladesh |
| topic | Umbilical cord serum Elementomics Early childhood neurodevelopment Bangladesh |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022002975 |
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