A systematic review of contaminants in donor human milk
Abstract Donor human milk (DHM) from a milk bank is the recommended feeding method for preterm infants when the mother's own milk (MOM) is not available. Despite this recommendation, information on the possible contamination of donor human milk and its impact on infant health outcomes is poorly...
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| Format: | Artikel |
| Sprache: | English |
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Wiley
2024-04-01
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| Schriftenreihe: | Maternal and Child Nutrition |
| Schlagworte: | |
| Online Zugang: | https://doi.org/10.1111/mcn.13627 |
| _version_ | 1827572286832508928 |
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| author | Sionika Thayagabalu Nicole Cacho Sandra Sullivan John Smulian Adetola Louis‐Jacques Marie Bourgeois Henian Chen Wasana Weerasuriya Dominick J. Lemas |
| author_facet | Sionika Thayagabalu Nicole Cacho Sandra Sullivan John Smulian Adetola Louis‐Jacques Marie Bourgeois Henian Chen Wasana Weerasuriya Dominick J. Lemas |
| author_sort | Sionika Thayagabalu |
| collection | DOAJ |
| description | Abstract Donor human milk (DHM) from a milk bank is the recommended feeding method for preterm infants when the mother's own milk (MOM) is not available. Despite this recommendation, information on the possible contamination of donor human milk and its impact on infant health outcomes is poorly characterised. The aim of this systematic review is to assess contaminants present in DHM samples that preterm and critically ill infants consume. The data sources used include PubMed, EMBASE, CINAHL and Web of Science. A search of the data sources targeting DHM and its potential contaminants yielded 426 publications. Two reviewers (S. T. and D. L.) conducted title/abstract screening through Covidence software, and predetermined inclusion/exclusion criteria yielded 26 manuscripts. Contaminant types (bacterial, chemical, fungal, viral) and study details (e.g., type of bacteria identified, study setting) were extracted from each included study during full‐text review. Primary contaminants in donor human milk included bacterial species and environmental pollutants. We found that bacterial contaminants were identified in 100% of the papers in which bacterial contamination was sought (16 papers) and 61.5% of the full data set (26 papers), with the most frequently identified genera being Staphylococcus (e.g., Staphylococcus aureus and coagulase‐negative Staphylococcus) and Bacillus (e.g., Bacillus cereus). Chemical pollutants were discovered in 100% of the papers in which chemical contamination was sought (eight papers) and 30.8% of the full data set (26 papers). The most frequently identified chemical pollutants included perfluoroalkyl substances (six papers), toxic metal (one paper) and caffeine (one paper). Viral and fungal contamination were identified in one paper each. Our results highlight the importance of establishing standardisation in assessing DHM contamination and future studies are needed to clarify the impact of DHM contaminants on health outcomes. |
| first_indexed | 2024-04-24T16:27:21Z |
| format | Article |
| id | doaj.art-c5c8dae2d9344469a2c7488bea6f115d |
| institution | Directory Open Access Journal |
| issn | 1740-8695 1740-8709 |
| language | English |
| last_indexed | 2024-04-24T16:27:21Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Maternal and Child Nutrition |
| spelling | doaj.art-c5c8dae2d9344469a2c7488bea6f115d2024-03-30T17:45:18ZengWileyMaternal and Child Nutrition1740-86951740-87092024-04-01202n/an/a10.1111/mcn.13627A systematic review of contaminants in donor human milkSionika Thayagabalu0Nicole Cacho1Sandra Sullivan2John Smulian3Adetola Louis‐Jacques4Marie Bourgeois5Henian Chen6Wasana Weerasuriya7Dominick J. Lemas8Department of Health Outcomes and Biomedical Informatics, College of Medicine University of Florida Gainesville Florida USADepartment of Pediatrics, Division of Neonatology University of California Davis California USAEnvision Healthcare, HCA Florida North Florida Hospital Gainesville Florida USADepartment of Obstetrics and Gynecology, College of Medicine University of Florida Gainesville Florida USADepartment of Obstetrics and Gynecology, College of Medicine University of Florida Gainesville Florida USADepartment of Public Health University of South Florida Tampa Florida USADepartment of Public Health University of South Florida Tampa Florida USADepartment of Public Health University of South Florida Tampa Florida USADepartment of Health Outcomes and Biomedical Informatics, College of Medicine University of Florida Gainesville Florida USAAbstract Donor human milk (DHM) from a milk bank is the recommended feeding method for preterm infants when the mother's own milk (MOM) is not available. Despite this recommendation, information on the possible contamination of donor human milk and its impact on infant health outcomes is poorly characterised. The aim of this systematic review is to assess contaminants present in DHM samples that preterm and critically ill infants consume. The data sources used include PubMed, EMBASE, CINAHL and Web of Science. A search of the data sources targeting DHM and its potential contaminants yielded 426 publications. Two reviewers (S. T. and D. L.) conducted title/abstract screening through Covidence software, and predetermined inclusion/exclusion criteria yielded 26 manuscripts. Contaminant types (bacterial, chemical, fungal, viral) and study details (e.g., type of bacteria identified, study setting) were extracted from each included study during full‐text review. Primary contaminants in donor human milk included bacterial species and environmental pollutants. We found that bacterial contaminants were identified in 100% of the papers in which bacterial contamination was sought (16 papers) and 61.5% of the full data set (26 papers), with the most frequently identified genera being Staphylococcus (e.g., Staphylococcus aureus and coagulase‐negative Staphylococcus) and Bacillus (e.g., Bacillus cereus). Chemical pollutants were discovered in 100% of the papers in which chemical contamination was sought (eight papers) and 30.8% of the full data set (26 papers). The most frequently identified chemical pollutants included perfluoroalkyl substances (six papers), toxic metal (one paper) and caffeine (one paper). Viral and fungal contamination were identified in one paper each. Our results highlight the importance of establishing standardisation in assessing DHM contamination and future studies are needed to clarify the impact of DHM contaminants on health outcomes.https://doi.org/10.1111/mcn.13627breast milkcontaminantsdonor milk |
| spellingShingle | Sionika Thayagabalu Nicole Cacho Sandra Sullivan John Smulian Adetola Louis‐Jacques Marie Bourgeois Henian Chen Wasana Weerasuriya Dominick J. Lemas A systematic review of contaminants in donor human milk Maternal and Child Nutrition breast milk contaminants donor milk |
| title | A systematic review of contaminants in donor human milk |
| title_full | A systematic review of contaminants in donor human milk |
| title_fullStr | A systematic review of contaminants in donor human milk |
| title_full_unstemmed | A systematic review of contaminants in donor human milk |
| title_short | A systematic review of contaminants in donor human milk |
| title_sort | systematic review of contaminants in donor human milk |
| topic | breast milk contaminants donor milk |
| url | https://doi.org/10.1111/mcn.13627 |
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