Design, synthesis and anticancer evaluation of various aryl amide derivatives of thiazole-benzothiazole-pyrimidines
We have developed a new series of various aryl amide derivatives of thiazole-benzothaizole-pyrimidines (13a-j). Their chemical structures were characterized by 1HNMR, 13CNMR and mass spectral data. Further, in vitro anticancer properties of newly developed compounds 13a-j were investigated against f...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624000997 |
| _version_ | 1797267208520335360 |
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| author | Shanti Priya Vemuluri Vijaya Laxmi Somarapu Laxminarayana Eppakayala |
| author_facet | Shanti Priya Vemuluri Vijaya Laxmi Somarapu Laxminarayana Eppakayala |
| author_sort | Shanti Priya Vemuluri |
| collection | DOAJ |
| description | We have developed a new series of various aryl amide derivatives of thiazole-benzothaizole-pyrimidines (13a-j). Their chemical structures were characterized by 1HNMR, 13CNMR and mass spectral data. Further, in vitro anticancer properties of newly developed compounds 13a-j were investigated against four human cancer cell lines including MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) & A2780 (ovarian cancer) by employing the MTT assay, and were compared with etoposide used as a standard reference. Most of the tested compounds displayed moderate to good anticancer activities compared to etoposide. The in vitro assay results indicated that compounds 13a, 13b, 13c and 13d possessed more potent activity as compared with the standard. One of the compounds, like 13a displayed superior anticancer activity. |
| first_indexed | 2024-04-25T01:12:56Z |
| format | Article |
| id | doaj.art-c5c9b7497a154102be6343354c3b12ef |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-25T01:12:56Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-c5c9b7497a154102be6343354c3b12ef2024-03-10T05:12:09ZengElsevierResults in Chemistry2211-71562024-01-017101403Design, synthesis and anticancer evaluation of various aryl amide derivatives of thiazole-benzothiazole-pyrimidinesShanti Priya Vemuluri0Vijaya Laxmi Somarapu1Laxminarayana Eppakayala2Department of Chemistry, Palamuru University, Mahabubnagar, Telangana 509001, IndiaDepartment of Chemistry, Palamuru University, Mahabubnagar, Telangana 509001, India; Corresponding author.Department of Medicinal chemistry, Sreenidhi Institute of Science and Technology (Autonomous), Yamnampet, Ghatkesar 501301, Telangana, IndiaWe have developed a new series of various aryl amide derivatives of thiazole-benzothaizole-pyrimidines (13a-j). Their chemical structures were characterized by 1HNMR, 13CNMR and mass spectral data. Further, in vitro anticancer properties of newly developed compounds 13a-j were investigated against four human cancer cell lines including MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) & A2780 (ovarian cancer) by employing the MTT assay, and were compared with etoposide used as a standard reference. Most of the tested compounds displayed moderate to good anticancer activities compared to etoposide. The in vitro assay results indicated that compounds 13a, 13b, 13c and 13d possessed more potent activity as compared with the standard. One of the compounds, like 13a displayed superior anticancer activity.http://www.sciencedirect.com/science/article/pii/S2211715624000997NSC-710305BenzothiazoleImatinibPyrimidine and anticancer activity |
| spellingShingle | Shanti Priya Vemuluri Vijaya Laxmi Somarapu Laxminarayana Eppakayala Design, synthesis and anticancer evaluation of various aryl amide derivatives of thiazole-benzothiazole-pyrimidines Results in Chemistry NSC-710305 Benzothiazole Imatinib Pyrimidine and anticancer activity |
| title | Design, synthesis and anticancer evaluation of various aryl amide derivatives of thiazole-benzothiazole-pyrimidines |
| title_full | Design, synthesis and anticancer evaluation of various aryl amide derivatives of thiazole-benzothiazole-pyrimidines |
| title_fullStr | Design, synthesis and anticancer evaluation of various aryl amide derivatives of thiazole-benzothiazole-pyrimidines |
| title_full_unstemmed | Design, synthesis and anticancer evaluation of various aryl amide derivatives of thiazole-benzothiazole-pyrimidines |
| title_short | Design, synthesis and anticancer evaluation of various aryl amide derivatives of thiazole-benzothiazole-pyrimidines |
| title_sort | design synthesis and anticancer evaluation of various aryl amide derivatives of thiazole benzothiazole pyrimidines |
| topic | NSC-710305 Benzothiazole Imatinib Pyrimidine and anticancer activity |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624000997 |
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