Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices
Abstract Intestinal retentive devices have applications ranging from sustained oral drug delivery systems to indwelling ingestible medical devices. Current strategies to retain devices in the small intestine primarily focus on chemical anchoring using mucoadhesives or mechanical coupling using expan...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202301084 |
| _version_ | 1827782616195006464 |
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| author | Durva Naik Gaurav Balakrishnan Mahathy Rajagopalan Xiaozili Huang Nihar Trivedi Arnav Bhat Christopher J. Bettinger |
| author_facet | Durva Naik Gaurav Balakrishnan Mahathy Rajagopalan Xiaozili Huang Nihar Trivedi Arnav Bhat Christopher J. Bettinger |
| author_sort | Durva Naik |
| collection | DOAJ |
| description | Abstract Intestinal retentive devices have applications ranging from sustained oral drug delivery systems to indwelling ingestible medical devices. Current strategies to retain devices in the small intestine primarily focus on chemical anchoring using mucoadhesives or mechanical coupling using expandable devices or structures that pierce the intestinal epithelium. Here, the feasibility of intestinal retention using devices containing villi‐inspired structures that mechanically interlock with natural villi of the small intestine is evaluated. First the viability of mechanical interlocking as an intestinal retention strategy is estimated by estimating the resistance to peristaltic shear between simulated natural villi and devices with various micropost geometries and parameters. Simulations are validated in vitro by fabricating micropost array patches via multistep replica molding and performing lap‐shear tests to evaluate the interlocking performance of the fabricated microposts with artificial villi. Finally, the optimal material and design parameters of the patches that can successfully achieve retention in vivo are predicted. This study represents a proof‐of‐concept for the viability of micropost‐villi mechanical interlocking strategy to develop nonpenetrative multifunctional intestinal retentive devices for the future. |
| first_indexed | 2024-03-11T15:35:27Z |
| format | Article |
| id | doaj.art-c5c9ddd04f7b4270aa9573ff0ec863f3 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-11T15:35:27Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-c5c9ddd04f7b4270aa9573ff0ec863f32023-10-26T20:10:11ZengWileyAdvanced Science2198-38442023-10-011030n/an/a10.1002/advs.202301084Villi Inspired Mechanical Interlocking for Intestinal Retentive DevicesDurva Naik0Gaurav Balakrishnan1Mahathy Rajagopalan2Xiaozili Huang3Nihar Trivedi4Arnav Bhat5Christopher J. Bettinger6Materials Science and Engineering Department Carnegie Mellon University 5000 Forbes Avenue, Wean Hall, 3325PittsburghPA15213USAMaterials Science and Engineering Department Carnegie Mellon University 5000 Forbes Avenue, Wean Hall, 3325PittsburghPA15213USABiomedical Engineering Department Carnegie Mellon University 5000 Forbes Avenue, Scott Hall, 4N201PittsburghPA15213USAMaterials Science and Engineering Department Carnegie Mellon University 5000 Forbes Avenue, Wean Hall, 3325PittsburghPA15213USAMaterials Science and Engineering Department Carnegie Mellon University 5000 Forbes Avenue, Wean Hall, 3325PittsburghPA15213USABiomedical Engineering Department Carnegie Mellon University 5000 Forbes Avenue, Scott Hall, 4N201PittsburghPA15213USAMaterials Science and Engineering Department Carnegie Mellon University 5000 Forbes Avenue, Wean Hall, 3325PittsburghPA15213USAAbstract Intestinal retentive devices have applications ranging from sustained oral drug delivery systems to indwelling ingestible medical devices. Current strategies to retain devices in the small intestine primarily focus on chemical anchoring using mucoadhesives or mechanical coupling using expandable devices or structures that pierce the intestinal epithelium. Here, the feasibility of intestinal retention using devices containing villi‐inspired structures that mechanically interlock with natural villi of the small intestine is evaluated. First the viability of mechanical interlocking as an intestinal retention strategy is estimated by estimating the resistance to peristaltic shear between simulated natural villi and devices with various micropost geometries and parameters. Simulations are validated in vitro by fabricating micropost array patches via multistep replica molding and performing lap‐shear tests to evaluate the interlocking performance of the fabricated microposts with artificial villi. Finally, the optimal material and design parameters of the patches that can successfully achieve retention in vivo are predicted. This study represents a proof‐of‐concept for the viability of micropost‐villi mechanical interlocking strategy to develop nonpenetrative multifunctional intestinal retentive devices for the future.https://doi.org/10.1002/advs.202301084digital light processing (DLP) 3D printingintestinal retentionmechanical interlockingmicrostructuresreplica moldingvilli |
| spellingShingle | Durva Naik Gaurav Balakrishnan Mahathy Rajagopalan Xiaozili Huang Nihar Trivedi Arnav Bhat Christopher J. Bettinger Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices Advanced Science digital light processing (DLP) 3D printing intestinal retention mechanical interlocking microstructures replica molding villi |
| title | Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices |
| title_full | Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices |
| title_fullStr | Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices |
| title_full_unstemmed | Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices |
| title_short | Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices |
| title_sort | villi inspired mechanical interlocking for intestinal retentive devices |
| topic | digital light processing (DLP) 3D printing intestinal retention mechanical interlocking microstructures replica molding villi |
| url | https://doi.org/10.1002/advs.202301084 |
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