FROM THE RETICULO-ENDOTHELIAL TO MONONUCLEAR PHAGOCYTE SYSTEM- THE UNACCOUNTED YEARS
It is over 125 years since Ilya Metchnikoff described the significance of phagocytosis. In this review we examine the early origins and development of macrophage research continuing after his death in 1916, through the period of the Reticulo-Endothelial System. Studies on these cells resulted in a s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00328/full |
| _version_ | 1819200311081828352 |
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| author | Simon eYona Siamon eGordon |
| author_facet | Simon eYona Siamon eGordon |
| author_sort | Simon eYona |
| collection | DOAJ |
| description | It is over 125 years since Ilya Metchnikoff described the significance of phagocytosis. In this review we examine the early origins and development of macrophage research continuing after his death in 1916, through the period of the Reticulo-Endothelial System. Studies on these cells resulted in a substantial literature spanning immunology, haematology, biochemistry and pathology. Early histological studies on morphology and in situ labelling laid the foundations to appreciate the diversity and functional capacity of these cells in the steady state and during pathology. We complete this phagocyte retrospective with the establishment of the Mononuclear Phagocyte System nomenclature half a century ago. |
| first_indexed | 2024-12-23T03:30:13Z |
| format | Article |
| id | doaj.art-c5ca0a7aeec245c2bb5f90ea1e9ba1cb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T03:30:13Z |
| publishDate | 2015-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c5ca0a7aeec245c2bb5f90ea1e9ba1cb2022-12-21T18:01:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242015-07-01610.3389/fimmu.2015.00328148591FROM THE RETICULO-ENDOTHELIAL TO MONONUCLEAR PHAGOCYTE SYSTEM- THE UNACCOUNTED YEARSSimon eYona0Siamon eGordon1University College LondonThe University of OxfordIt is over 125 years since Ilya Metchnikoff described the significance of phagocytosis. In this review we examine the early origins and development of macrophage research continuing after his death in 1916, through the period of the Reticulo-Endothelial System. Studies on these cells resulted in a substantial literature spanning immunology, haematology, biochemistry and pathology. Early histological studies on morphology and in situ labelling laid the foundations to appreciate the diversity and functional capacity of these cells in the steady state and during pathology. We complete this phagocyte retrospective with the establishment of the Mononuclear Phagocyte System nomenclature half a century ago.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00328/fullDendritic CellsInflammationPhagocytosismacrophagemonocyteMetchnikoff |
| spellingShingle | Simon eYona Siamon eGordon FROM THE RETICULO-ENDOTHELIAL TO MONONUCLEAR PHAGOCYTE SYSTEM- THE UNACCOUNTED YEARS Frontiers in Immunology Dendritic Cells Inflammation Phagocytosis macrophage monocyte Metchnikoff |
| title | FROM THE RETICULO-ENDOTHELIAL TO MONONUCLEAR PHAGOCYTE SYSTEM- THE UNACCOUNTED YEARS |
| title_full | FROM THE RETICULO-ENDOTHELIAL TO MONONUCLEAR PHAGOCYTE SYSTEM- THE UNACCOUNTED YEARS |
| title_fullStr | FROM THE RETICULO-ENDOTHELIAL TO MONONUCLEAR PHAGOCYTE SYSTEM- THE UNACCOUNTED YEARS |
| title_full_unstemmed | FROM THE RETICULO-ENDOTHELIAL TO MONONUCLEAR PHAGOCYTE SYSTEM- THE UNACCOUNTED YEARS |
| title_short | FROM THE RETICULO-ENDOTHELIAL TO MONONUCLEAR PHAGOCYTE SYSTEM- THE UNACCOUNTED YEARS |
| title_sort | from the reticulo endothelial to mononuclear phagocyte system the unaccounted years |
| topic | Dendritic Cells Inflammation Phagocytosis macrophage monocyte Metchnikoff |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00328/full |
| work_keys_str_mv | AT simoneyona fromthereticuloendothelialtomononuclearphagocytesystemtheunaccountedyears AT siamonegordon fromthereticuloendothelialtomononuclearphagocytesystemtheunaccountedyears |