The <em>Anemonia viridis</em> Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research
Blue biotechnologies implement marine bio-resources for addressing practical concerns. The isolation of biologically active molecules from marine animals is one of the main ways this field develops. Strikingly, cnidaria are considered as sustainable resources for this purpose, as they possess unique...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-10-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/16/11/407 |
| _version_ | 1798006271815712768 |
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| author | Aldo Nicosia Alexander Mikov Matteo Cammarata Paolo Colombo Yaroslav Andreev Sergey Kozlov Angela Cuttitta |
| author_facet | Aldo Nicosia Alexander Mikov Matteo Cammarata Paolo Colombo Yaroslav Andreev Sergey Kozlov Angela Cuttitta |
| author_sort | Aldo Nicosia |
| collection | DOAJ |
| description | Blue biotechnologies implement marine bio-resources for addressing practical concerns. The isolation of biologically active molecules from marine animals is one of the main ways this field develops. Strikingly, cnidaria are considered as sustainable resources for this purpose, as they possess unique cells for attack and protection, producing an articulated cocktail of bioactive substances. The Mediterranean sea anemone <i>Anemonia viridis</i> has been studied extensively for years. In this short review, we summarize advances in bioprospecting of the <i>A. viridis</i> toxin arsenal. <i>A. viridis</i> RNA datasets and toxin data mining approaches are briefly described. Analysis reveals the major pool of neurotoxins of <i>A. viridis</i>, which are particularly active on sodium and potassium channels. This review therefore integrates progress in both RNA-Seq based and biochemical-based bioprospecting of <i>A. viridis</i> toxins for biotechnological exploitation. |
| first_indexed | 2024-04-11T12:52:12Z |
| format | Article |
| id | doaj.art-c5ca350434984c57a189f34044fad752 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:52:12Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-c5ca350434984c57a189f34044fad7522022-12-22T04:23:10ZengMDPI AGMarine Drugs1660-33972018-10-01161140710.3390/md16110407md16110407The <em>Anemonia viridis</em> Venom: Coupling Biochemical Purification and RNA-Seq for Translational ResearchAldo Nicosia0Alexander Mikov1Matteo Cammarata2Paolo Colombo3Yaroslav Andreev4Sergey Kozlov5Angela Cuttitta6National Research Council-Institute for the Study of Anthropogenic Impacts and Sustainability in the Marine Environment (IAS-CNR), Laboratory of Molecular Ecology and Biotechnology, Capo Granitola, Via del mare, Campobello di Mazara (TP), 91021 Sicily, ItalyShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, GSP-7, ul. Miklukho-Maklaya, 16/10, 117997 Moscow, RussiaDepartment of Earth and Marine Sciences, University of Palermo, 90100 Palermo, ItalyIstituto di Biomedicina e di Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146 Palermo, ItalyShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, GSP-7, ul. Miklukho-Maklaya, 16/10, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, GSP-7, ul. Miklukho-Maklaya, 16/10, 117997 Moscow, RussiaNational Research Council-Institute for the Study of Anthropogenic Impacts and Sustainability in the Marine Environment (IAS-CNR), Laboratory of Molecular Ecology and Biotechnology, Capo Granitola, Via del mare, Campobello di Mazara (TP), 91021 Sicily, ItalyBlue biotechnologies implement marine bio-resources for addressing practical concerns. The isolation of biologically active molecules from marine animals is one of the main ways this field develops. Strikingly, cnidaria are considered as sustainable resources for this purpose, as they possess unique cells for attack and protection, producing an articulated cocktail of bioactive substances. The Mediterranean sea anemone <i>Anemonia viridis</i> has been studied extensively for years. In this short review, we summarize advances in bioprospecting of the <i>A. viridis</i> toxin arsenal. <i>A. viridis</i> RNA datasets and toxin data mining approaches are briefly described. Analysis reveals the major pool of neurotoxins of <i>A. viridis</i>, which are particularly active on sodium and potassium channels. This review therefore integrates progress in both RNA-Seq based and biochemical-based bioprospecting of <i>A. viridis</i> toxins for biotechnological exploitation.https://www.mdpi.com/1660-3397/16/11/407transcriptomicsbio-prospectingcomputational biologyneurotoxins |
| spellingShingle | Aldo Nicosia Alexander Mikov Matteo Cammarata Paolo Colombo Yaroslav Andreev Sergey Kozlov Angela Cuttitta The <em>Anemonia viridis</em> Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research Marine Drugs transcriptomics bio-prospecting computational biology neurotoxins |
| title | The <em>Anemonia viridis</em> Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research |
| title_full | The <em>Anemonia viridis</em> Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research |
| title_fullStr | The <em>Anemonia viridis</em> Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research |
| title_full_unstemmed | The <em>Anemonia viridis</em> Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research |
| title_short | The <em>Anemonia viridis</em> Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research |
| title_sort | em anemonia viridis em venom coupling biochemical purification and rna seq for translational research |
| topic | transcriptomics bio-prospecting computational biology neurotoxins |
| url | https://www.mdpi.com/1660-3397/16/11/407 |
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