A non-inferiority study to compare daily fast-acting insulin versus twice a week slow-acting insulin–moderate diabetes mode
Abstract Purpose Given the high prevalence of diabetes (D), several animal models have been analyzed. In the literature, most of the animal models have studied severe D. However, in clinical practice, most patients have moderate disease. Therefore, the present study aimed to describe a moderate D...
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| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2020-08-01
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| Series: | Acta Cirúrgica Brasileira |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502020000700201&tlng=en |
| _version_ | 1818491305411477504 |
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| author | Cristina Pires Camargo Rafael Hori Nagamine Weschenfelder Guilherme Moreira da Fonseca Alexandre Agostinho da Cruz Sousa Rolf Gemperli |
| author_facet | Cristina Pires Camargo Rafael Hori Nagamine Weschenfelder Guilherme Moreira da Fonseca Alexandre Agostinho da Cruz Sousa Rolf Gemperli |
| author_sort | Cristina Pires Camargo |
| collection | DOAJ |
| description | Abstract Purpose Given the high prevalence of diabetes (D), several animal models have been analyzed. In the literature, most of the animal models have studied severe D. However, in clinical practice, most patients have moderate disease. Therefore, the present study aimed to describe a moderate D condition. Methods We analyzed 20 Wistar rats, age eight-weeks, weight between 200g-250g. All animals received an intravenous injection of Streptozotocin (55mg/kg weight). On the 15th day after D induction, the animals were divided into two groups: Group I – animals receiving a single daily dose of fast-acting insulin (FAIG) NPH (1UI,SC) for partial glycemic control, and Group II - animals receiving slow-acting insulin(SAIG) twice a week. We measured glycemia, weight, and adverse events every week during two months. Results Of the total of animals analyzed in the study, three animals died in the FAIG and two animals died in the SAIG. Regarding the glycemic level, results were 339.5 ± 125.4mg/dL (95CI 302.3402 to 376.6842) in the FAIG, and 367.8 ± 66.1mg/dL (95IC 333.7607 to 401.8978) in the SAIG. There was no difference between groups as to weight during the study. Conclusion The use of slow-acting-insulin is not inferior to the use of fast-acting-insulin in the management of partially insulin-controlled moderate diabetes in rats. |
| first_indexed | 2024-12-10T17:29:04Z |
| format | Article |
| id | doaj.art-c5cb3008838a4fb09550a1729c3d26a5 |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-10T17:29:04Z |
| publishDate | 2020-08-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-c5cb3008838a4fb09550a1729c3d26a52022-12-22T01:39:44ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502020-08-0135710.1590/s0102-865020200070000004A non-inferiority study to compare daily fast-acting insulin versus twice a week slow-acting insulin–moderate diabetes modeCristina Pires Camargohttps://orcid.org/0000-0002-3134-0003Rafael Hori Nagamine Weschenfelderhttps://orcid.org/0000-0001-8747-6658Guilherme Moreira da Fonsecahttps://orcid.org/0000-0001-8198-415XAlexandre Agostinho da Cruz Sousahttps://orcid.org/0000-0003-3844-9973Rolf Gemperlihttps://orcid.org/0000-0001-9913-6079Abstract Purpose Given the high prevalence of diabetes (D), several animal models have been analyzed. In the literature, most of the animal models have studied severe D. However, in clinical practice, most patients have moderate disease. Therefore, the present study aimed to describe a moderate D condition. Methods We analyzed 20 Wistar rats, age eight-weeks, weight between 200g-250g. All animals received an intravenous injection of Streptozotocin (55mg/kg weight). On the 15th day after D induction, the animals were divided into two groups: Group I – animals receiving a single daily dose of fast-acting insulin (FAIG) NPH (1UI,SC) for partial glycemic control, and Group II - animals receiving slow-acting insulin(SAIG) twice a week. We measured glycemia, weight, and adverse events every week during two months. Results Of the total of animals analyzed in the study, three animals died in the FAIG and two animals died in the SAIG. Regarding the glycemic level, results were 339.5 ± 125.4mg/dL (95CI 302.3402 to 376.6842) in the FAIG, and 367.8 ± 66.1mg/dL (95IC 333.7607 to 401.8978) in the SAIG. There was no difference between groups as to weight during the study. Conclusion The use of slow-acting-insulin is not inferior to the use of fast-acting-insulin in the management of partially insulin-controlled moderate diabetes in rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502020000700201&tlng=enDiabetes mellitusInsulinRats |
| spellingShingle | Cristina Pires Camargo Rafael Hori Nagamine Weschenfelder Guilherme Moreira da Fonseca Alexandre Agostinho da Cruz Sousa Rolf Gemperli A non-inferiority study to compare daily fast-acting insulin versus twice a week slow-acting insulin–moderate diabetes mode Acta Cirúrgica Brasileira Diabetes mellitus Insulin Rats |
| title | A non-inferiority study to compare daily fast-acting insulin versus twice a week slow-acting insulin–moderate diabetes mode |
| title_full | A non-inferiority study to compare daily fast-acting insulin versus twice a week slow-acting insulin–moderate diabetes mode |
| title_fullStr | A non-inferiority study to compare daily fast-acting insulin versus twice a week slow-acting insulin–moderate diabetes mode |
| title_full_unstemmed | A non-inferiority study to compare daily fast-acting insulin versus twice a week slow-acting insulin–moderate diabetes mode |
| title_short | A non-inferiority study to compare daily fast-acting insulin versus twice a week slow-acting insulin–moderate diabetes mode |
| title_sort | non inferiority study to compare daily fast acting insulin versus twice a week slow acting insulin moderate diabetes mode |
| topic | Diabetes mellitus Insulin Rats |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502020000700201&tlng=en |
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