Synthesis and Biological Activity of 12-Aza-Epothilones (Azathilones) – Non-Natural Natural Products with Potent Antiproliferative Activity
12-Aza-epothilones ('Azathilones') 1 and 2 have been prepared through ring-closing olefin metathesis or macrolactonization-based cyclization reactions. While RCM of the respective dienes 9 and 12 was found to be very effective and produced macrocyclic olefins with high E selectiv...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2007-04-01
|
| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/4295 |