Ex vivo enrichment of PRAME antigen‐specific T cells for adoptive immunotherapy using CD137 activation marker selection

Ex vivo enrichment of PRAME antigen‐specific T cells for adoptive immunotherapy using CD137 activation marker selection

Abstract Objective Adoptive immunotherapy with ex vivo expanded tumor‐specific T cells has potential as anticancer therapy. Preferentially expressed antigen in melanoma (PRAME) is an attractive target overexpressed in several cancers including melanoma and acute myeloid leukaemia (AML), with low exp...

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Bibliographic Details
Main Authors: Koon H Lee, Kavitha Gowrishankar, Janine Street, Helen M McGuire, Fabio Luciani, Brendan Hughes, Mandeep Singh, Leighton E Clancy, David J Gottlieb, Kenneth P Micklethwaite, Emily Blyth
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical & Translational Immunology
Subjects:
adoptive immunotherapy
antigen‐specific T cells
PRAME
preferential expressed antigen in melanoma
Online Access:https://doi.org/10.1002/cti2.1200

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