Polymorphisms in Fatty Acid Desaturase 2 Gene Are Associated with Milk Production Traits in Chinese Holstein Cows
This study investigated the single nucleotide polymorphisms (SNPs) of Fatty acid desaturase 2 (<i>FADS2</i>) gene and further explored their genetic effects on conventionally collected milk production traits in Chinese Holstein cows using 18,264 test-day records of 841 cows. One missense...
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MDPI AG
2020-04-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/10/4/671 |
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| author | Mingxun Li Qisong Gao Mengqi Wang Yan Liang Yujia Sun Zhi Chen Huimin Zhang Niel A. Karrow Zhangping Yang Yongjiang Mao |
| author_facet | Mingxun Li Qisong Gao Mengqi Wang Yan Liang Yujia Sun Zhi Chen Huimin Zhang Niel A. Karrow Zhangping Yang Yongjiang Mao |
| author_sort | Mingxun Li |
| collection | DOAJ |
| description | This study investigated the single nucleotide polymorphisms (SNPs) of Fatty acid desaturase 2 (<i>FADS2</i>) gene and further explored their genetic effects on conventionally collected milk production traits in Chinese Holstein cows using 18,264 test-day records of 841 cows. One missense mutation c. 908 C > T (SNP site in the complementary DNA sequence), which caused an amino acid change from alanine to valine (294Ala > Val), and two 3’ untranslated region (UTR) SNPs, c.1571 G > A and c.2776 A > G were finally identified. The SNP c.908 C > T was significantly associated with test-day milk yield, fat percentage and 305-day milk, fat and protein yield. In particular, the T allele of the SNP c.908 C > T showed a significant association with decreased somatic cell score (SCS) in the investigated population. Significant relationship between the SNP c.1571 G > A and 305-day milk yield showed that genotype GG was linked to the highest milk yield. Substituting the allele G for A at the c.2776 A > G locus resulted in a decrease of protein percentage. Our results demonstrated that <i>FADS2</i> was an interesting candidate for selection to increase milk production and improve resistance against mastitis. |
| first_indexed | 2024-03-10T20:31:21Z |
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| id | doaj.art-c5d090d5784749a8b71ef6497d66fa05 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T20:31:21Z |
| publishDate | 2020-04-01 |
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| series | Animals |
| spelling | doaj.art-c5d090d5784749a8b71ef6497d66fa052023-11-19T21:26:01ZengMDPI AGAnimals2076-26152020-04-0110467110.3390/ani10040671Polymorphisms in Fatty Acid Desaturase 2 Gene Are Associated with Milk Production Traits in Chinese Holstein CowsMingxun Li0Qisong Gao1Mengqi Wang2Yan Liang3Yujia Sun4Zhi Chen5Huimin Zhang6Niel A. Karrow7Zhangping Yang8Yongjiang Mao9Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou 225009, ChinaKey Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou 225009, ChinaKey Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou 225009, ChinaKey Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou 225009, ChinaJoint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, ChinaKey Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou 225009, ChinaKey Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou 225009, ChinaCenter for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, CanadaKey Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou 225009, ChinaKey Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou 225009, ChinaThis study investigated the single nucleotide polymorphisms (SNPs) of Fatty acid desaturase 2 (<i>FADS2</i>) gene and further explored their genetic effects on conventionally collected milk production traits in Chinese Holstein cows using 18,264 test-day records of 841 cows. One missense mutation c. 908 C > T (SNP site in the complementary DNA sequence), which caused an amino acid change from alanine to valine (294Ala > Val), and two 3’ untranslated region (UTR) SNPs, c.1571 G > A and c.2776 A > G were finally identified. The SNP c.908 C > T was significantly associated with test-day milk yield, fat percentage and 305-day milk, fat and protein yield. In particular, the T allele of the SNP c.908 C > T showed a significant association with decreased somatic cell score (SCS) in the investigated population. Significant relationship between the SNP c.1571 G > A and 305-day milk yield showed that genotype GG was linked to the highest milk yield. Substituting the allele G for A at the c.2776 A > G locus resulted in a decrease of protein percentage. Our results demonstrated that <i>FADS2</i> was an interesting candidate for selection to increase milk production and improve resistance against mastitis.https://www.mdpi.com/2076-2615/10/4/671fatty acid desaturase 2single nucleotide polymorphismsmilk production traitssomatic cell score |
| spellingShingle | Mingxun Li Qisong Gao Mengqi Wang Yan Liang Yujia Sun Zhi Chen Huimin Zhang Niel A. Karrow Zhangping Yang Yongjiang Mao Polymorphisms in Fatty Acid Desaturase 2 Gene Are Associated with Milk Production Traits in Chinese Holstein Cows Animals fatty acid desaturase 2 single nucleotide polymorphisms milk production traits somatic cell score |
| title | Polymorphisms in Fatty Acid Desaturase 2 Gene Are Associated with Milk Production Traits in Chinese Holstein Cows |
| title_full | Polymorphisms in Fatty Acid Desaturase 2 Gene Are Associated with Milk Production Traits in Chinese Holstein Cows |
| title_fullStr | Polymorphisms in Fatty Acid Desaturase 2 Gene Are Associated with Milk Production Traits in Chinese Holstein Cows |
| title_full_unstemmed | Polymorphisms in Fatty Acid Desaturase 2 Gene Are Associated with Milk Production Traits in Chinese Holstein Cows |
| title_short | Polymorphisms in Fatty Acid Desaturase 2 Gene Are Associated with Milk Production Traits in Chinese Holstein Cows |
| title_sort | polymorphisms in fatty acid desaturase 2 gene are associated with milk production traits in chinese holstein cows |
| topic | fatty acid desaturase 2 single nucleotide polymorphisms milk production traits somatic cell score |
| url | https://www.mdpi.com/2076-2615/10/4/671 |
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