Development of Multilayer Ciprofloxacin Hydrochloride Electrospun Patches for Buccal Drug Delivery
Bacterial infections in the oral cavity can become a serious problem causing pain, sores and swelling for several weeks. This type of infection could be alleviated using mucoadhesive delivery systems, allowing local administration of the antibiotic to inhibit bacterial spreading. This work reports t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/170 |
| _version_ | 1797457020228468736 |
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| author | Jorge Teno Maria Pardo-Figuerez Kelly J. Figueroa-Lopez Cristina Prieto Jose M. Lagaron |
| author_facet | Jorge Teno Maria Pardo-Figuerez Kelly J. Figueroa-Lopez Cristina Prieto Jose M. Lagaron |
| author_sort | Jorge Teno |
| collection | DOAJ |
| description | Bacterial infections in the oral cavity can become a serious problem causing pain, sores and swelling for several weeks. This type of infection could be alleviated using mucoadhesive delivery systems, allowing local administration of the antibiotic to inhibit bacterial spreading. This work reports the development of a multilayer antibiotic patch containing ciprofloxacin hydrochloride (CPX)-loaded electrospun fibers for the treatment of such infections. For this, the release kinetics of the CPX-loaded fibers was modulated using different ratios of polyester blends. The selected reservoir layer was analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), wide angle x-ray scattering (WAXS) and differential scanning calorimetry (DSC). These analyses confirmed the presence and good distribution of the drug in the fibers and that the drug is in an amorphous state within the reservoir layer. To enhance mucoadhesion whilst ensuring drug directionality, the reservoir layer was assembled to a backing and an adhesive layer. This multilayer patch was assessed in terms of in vitro drug release, adhesion and antimicrobial properties. The multilayer strategy showed excellent antimicrobial properties over time and also a strong adhesion patch time in the volunteers for an average of 7 h. These results highlight the capabilities of multilayer electrospun patches as platforms to treat oral infections. |
| first_indexed | 2024-03-09T16:16:10Z |
| format | Article |
| id | doaj.art-c5d0c49257a74d839481367da5ea5d5e |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:16:10Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-c5d0c49257a74d839481367da5ea5d5e2023-11-24T15:48:50ZengMDPI AGJournal of Functional Biomaterials2079-49832022-09-0113417010.3390/jfb13040170Development of Multilayer Ciprofloxacin Hydrochloride Electrospun Patches for Buccal Drug DeliveryJorge Teno0Maria Pardo-Figuerez1Kelly J. Figueroa-Lopez2Cristina Prieto3Jose M. Lagaron4R&D Department, Bioinicia S.L., Calle Algepser 65 nave 3, Paterna, 46980 Valencia, SpainNovel Materials and Nanotechnology Group, Institute of Agrochemistry and Food Technology (IATA), Spanish Council for Scientific Research (CSIC), Calle Catedrático Agustín Escardino Benlloch 7, Paterna, 46980 Valencia, SpainNovel Materials and Nanotechnology Group, Institute of Agrochemistry and Food Technology (IATA), Spanish Council for Scientific Research (CSIC), Calle Catedrático Agustín Escardino Benlloch 7, Paterna, 46980 Valencia, SpainNovel Materials and Nanotechnology Group, Institute of Agrochemistry and Food Technology (IATA), Spanish Council for Scientific Research (CSIC), Calle Catedrático Agustín Escardino Benlloch 7, Paterna, 46980 Valencia, SpainNovel Materials and Nanotechnology Group, Institute of Agrochemistry and Food Technology (IATA), Spanish Council for Scientific Research (CSIC), Calle Catedrático Agustín Escardino Benlloch 7, Paterna, 46980 Valencia, SpainBacterial infections in the oral cavity can become a serious problem causing pain, sores and swelling for several weeks. This type of infection could be alleviated using mucoadhesive delivery systems, allowing local administration of the antibiotic to inhibit bacterial spreading. This work reports the development of a multilayer antibiotic patch containing ciprofloxacin hydrochloride (CPX)-loaded electrospun fibers for the treatment of such infections. For this, the release kinetics of the CPX-loaded fibers was modulated using different ratios of polyester blends. The selected reservoir layer was analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), wide angle x-ray scattering (WAXS) and differential scanning calorimetry (DSC). These analyses confirmed the presence and good distribution of the drug in the fibers and that the drug is in an amorphous state within the reservoir layer. To enhance mucoadhesion whilst ensuring drug directionality, the reservoir layer was assembled to a backing and an adhesive layer. This multilayer patch was assessed in terms of in vitro drug release, adhesion and antimicrobial properties. The multilayer strategy showed excellent antimicrobial properties over time and also a strong adhesion patch time in the volunteers for an average of 7 h. These results highlight the capabilities of multilayer electrospun patches as platforms to treat oral infections.https://www.mdpi.com/2079-4983/13/4/170ciprofloxacin hydrochlorideelectrospinningtransmucosal patchbiopolyesterantimicrobial |
| spellingShingle | Jorge Teno Maria Pardo-Figuerez Kelly J. Figueroa-Lopez Cristina Prieto Jose M. Lagaron Development of Multilayer Ciprofloxacin Hydrochloride Electrospun Patches for Buccal Drug Delivery Journal of Functional Biomaterials ciprofloxacin hydrochloride electrospinning transmucosal patch biopolyester antimicrobial |
| title | Development of Multilayer Ciprofloxacin Hydrochloride Electrospun Patches for Buccal Drug Delivery |
| title_full | Development of Multilayer Ciprofloxacin Hydrochloride Electrospun Patches for Buccal Drug Delivery |
| title_fullStr | Development of Multilayer Ciprofloxacin Hydrochloride Electrospun Patches for Buccal Drug Delivery |
| title_full_unstemmed | Development of Multilayer Ciprofloxacin Hydrochloride Electrospun Patches for Buccal Drug Delivery |
| title_short | Development of Multilayer Ciprofloxacin Hydrochloride Electrospun Patches for Buccal Drug Delivery |
| title_sort | development of multilayer ciprofloxacin hydrochloride electrospun patches for buccal drug delivery |
| topic | ciprofloxacin hydrochloride electrospinning transmucosal patch biopolyester antimicrobial |
| url | https://www.mdpi.com/2079-4983/13/4/170 |
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