Azoxystrobin Induces Apoptosis of Human Esophageal Squamous Cell Carcinoma KYSE-150 Cells through Triggering of the Mitochondrial Pathway

Azoxystrobin Induces Apoptosis of Human Esophageal Squamous Cell Carcinoma KYSE-150 Cells through Triggering of the Mitochondrial Pathway

Recent studies indicate that mitochondrial pathways of apoptosis are potential chemotherapeutic target for the treatment of esophageal cancer. Azoxystrobin (AZOX), a methoxyacrylate derived from the naturally occurring strobilurins, is a known fungicide acting as a ubiquinol oxidation (Qo) inhibitor...

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Bibliographic Details
Main Authors:	Xiao-ke Shi, Xiao-bo Bian, Tao Huang, Bo Wen, Ling Zhao, Huai-xue Mu, Sarwat Fatima, Bao-min Fan, Zhao-xiang Bian, Lin-fang Huang, Cheng-yuan Lin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-05-01
Series:	Frontiers in Pharmacology
Subjects:	azoxystrobin human esophageal squamous cell carcinoma apoptosis mitochondrial pathway anti-tumor
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00277/full

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