Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder that results from a complex interaction between genes and environment. Breastfeeding (BF) is thought to promote healthy cognitive development, and a body of research has suggested that it may also protect against ASD. Our objec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-27040-x |
| _version_ | 1797945975144185856 |
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| author | Marianne Peries Fanny Duhr Marie-Christine Picot Barbara Heude Jonathan Y. Bernard Amaria Baghdadli |
| author_facet | Marianne Peries Fanny Duhr Marie-Christine Picot Barbara Heude Jonathan Y. Bernard Amaria Baghdadli |
| author_sort | Marianne Peries |
| collection | DOAJ |
| description | Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder that results from a complex interaction between genes and environment. Breastfeeding (BF) is thought to promote healthy cognitive development, and a body of research has suggested that it may also protect against ASD. Our objectives were to identify the relationship between the initiation and duration of BF and the severity of clinical presentation in ASD. Data were collected from 243 children with a confirmed diagnosis of ASD followed in the ELENA cohort. Clinical severity was measured according to multiple dimensions using standardised tools. The frequency of the initiation of BF was comparable to that of the general population and the rate of children still being breastfed at six months of age was higher. Our results did not indicate a contribution of initiation or duration of BF to the prevention of clinical severity of ASD. We discuss our results in the light of possible methodological limitations of previous reports of an association between BF and ASD. Clinical Trial Registration: NCT02625116. |
| first_indexed | 2024-04-10T21:03:33Z |
| format | Article |
| id | doaj.art-c5d1221030f144298788be94f7d76ba6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T21:03:33Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c5d1221030f144298788be94f7d76ba62023-01-22T12:11:48ZengNature PortfolioScientific Reports2045-23222023-01-011311810.1038/s41598-022-27040-xBreastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohortMarianne Peries0Fanny Duhr1Marie-Christine Picot2Barbara Heude3Jonathan Y. Bernard4Amaria Baghdadli5Centre de Ressource Autisme Languedoc-Roussillon, CHU MontpellierCentre de Ressource Autisme Languedoc-Roussillon, CHU MontpellierCentre d’Excellence sur l’Autisme et les Troubles Neuro-développementaux (CeAnd), CHU MontpellierUniversité Paris Cité, Inserm, INRAE, Centre de Recherche en Épidémiologie et StatistiquesUniversité Paris Cité, Inserm, INRAE, Centre de Recherche en Épidémiologie et StatistiquesCentre de Ressource Autisme Languedoc-Roussillon, CHU MontpellierAbstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder that results from a complex interaction between genes and environment. Breastfeeding (BF) is thought to promote healthy cognitive development, and a body of research has suggested that it may also protect against ASD. Our objectives were to identify the relationship between the initiation and duration of BF and the severity of clinical presentation in ASD. Data were collected from 243 children with a confirmed diagnosis of ASD followed in the ELENA cohort. Clinical severity was measured according to multiple dimensions using standardised tools. The frequency of the initiation of BF was comparable to that of the general population and the rate of children still being breastfed at six months of age was higher. Our results did not indicate a contribution of initiation or duration of BF to the prevention of clinical severity of ASD. We discuss our results in the light of possible methodological limitations of previous reports of an association between BF and ASD. Clinical Trial Registration: NCT02625116.https://doi.org/10.1038/s41598-022-27040-x |
| spellingShingle | Marianne Peries Fanny Duhr Marie-Christine Picot Barbara Heude Jonathan Y. Bernard Amaria Baghdadli Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort Scientific Reports |
| title | Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort |
| title_full | Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort |
| title_fullStr | Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort |
| title_full_unstemmed | Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort |
| title_short | Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort |
| title_sort | breastfeeding is not a risk factor for clinical severity in autism spectrum disorder in children from the elena cohort |
| url | https://doi.org/10.1038/s41598-022-27040-x |
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