Enhancing the Antifungal Efficacy of Fluconazole with a Diterpene: Abietic Acid as a Promising Adjuvant to Combat Antifungal Resistance in <i>Candida</i> spp.

Enhancing the Antifungal Efficacy of Fluconazole with a Diterpene: Abietic Acid as a Promising Adjuvant to Combat Antifungal Resistance in <i>Candida</i> spp.

The increasing antifungal resistance rates against conventional drugs reveal the urgent need to search for new therapeutic alternatives. In this context, natural bioactive compounds have a critical role in antifungal drug development. Since evidence demonstrates that abietic acid, a diterpene found...

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Bibliographic Details
Main Authors: Maria Gabriely de Lima Silva, Luciene Ferreira de Lima, Victor Juno Alencar Fonseca, Lucas Yure Santos da Silva, Ana Cecília Calixto Donelardy, Ray Silva de Almeida, Cícera Datiane de Morais Oliveira-Tintino, Anita Oliveira Brito Pereira Bezerra Martins, Jaime Ribeiro-Filho, Maria Flaviana Bezerra Morais-Braga, Saulo Relison Tintino, Irwin Rose Alencar de Menezes
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Antibiotics
Subjects:
anti-<i>Candida</i> activity
abietic acid
fluconazole
antifungal resistance
Online Access:https://www.mdpi.com/2079-6382/12/11/1565

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