The Roles of Glycans in Bladder Cancer
Bladder cancer is one of the most common malignant tumors of the urogenital system with high morbidity and mortality worldwide. Early diagnosis and personalized treatment are the keys to successful bladder cancer treatment. Due to high postoperative recurrence rates and poor prognosis, it is urgent...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00957/full |
| _version_ | 1819266244574969856 |
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| author | Yuli Jian Zhongyang Xu Chunyan Xu Lin Zhang Xiaoxin Sun Deyong Yang Shujing Wang |
| author_facet | Yuli Jian Zhongyang Xu Chunyan Xu Lin Zhang Xiaoxin Sun Deyong Yang Shujing Wang |
| author_sort | Yuli Jian |
| collection | DOAJ |
| description | Bladder cancer is one of the most common malignant tumors of the urogenital system with high morbidity and mortality worldwide. Early diagnosis and personalized treatment are the keys to successful bladder cancer treatment. Due to high postoperative recurrence rates and poor prognosis, it is urgent to find suitable therapeutic targets and biomarkers. Glycans are one of the four biological macromolecules in the cells of an organism, along with proteins, nucleic acids, and lipids. Glycans play important roles in nascent peptide chain folding, protein processing, and translation, cell-to-cell adhesion, receptor-ligand recognition, and binding and cell signaling. Glycans are mainly divided into N-glycans, O-glycans, proteoglycans, and glycosphingolipids. The focus of this review is the discussion of glycans related to bladder cancer. Additionally, this review also addresses the clinical value of glycans in the diagnosis and treatment of bladder cancer. Abnormal glycans are likely to be potential biomarkers for bladder cancer. |
| first_indexed | 2024-12-23T20:58:12Z |
| format | Article |
| id | doaj.art-c5d2e7bc75594b57945440373b2f4413 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T20:58:12Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c5d2e7bc75594b57945440373b2f44132022-12-21T17:31:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-06-011010.3389/fonc.2020.00957544892The Roles of Glycans in Bladder CancerYuli Jian0Zhongyang Xu1Chunyan Xu2Lin Zhang3Xiaoxin Sun4Deyong Yang5Shujing Wang6Department of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, ChinaDepartment of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, ChinaDepartment of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, ChinaDepartment of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, ChinaDepartment of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, ChinaDepartment of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, ChinaBladder cancer is one of the most common malignant tumors of the urogenital system with high morbidity and mortality worldwide. Early diagnosis and personalized treatment are the keys to successful bladder cancer treatment. Due to high postoperative recurrence rates and poor prognosis, it is urgent to find suitable therapeutic targets and biomarkers. Glycans are one of the four biological macromolecules in the cells of an organism, along with proteins, nucleic acids, and lipids. Glycans play important roles in nascent peptide chain folding, protein processing, and translation, cell-to-cell adhesion, receptor-ligand recognition, and binding and cell signaling. Glycans are mainly divided into N-glycans, O-glycans, proteoglycans, and glycosphingolipids. The focus of this review is the discussion of glycans related to bladder cancer. Additionally, this review also addresses the clinical value of glycans in the diagnosis and treatment of bladder cancer. Abnormal glycans are likely to be potential biomarkers for bladder cancer.https://www.frontiersin.org/article/10.3389/fonc.2020.00957/fullglycansglycosyltransferasesbladder cancerabnormal glycosylationbiomarkers |
| spellingShingle | Yuli Jian Zhongyang Xu Chunyan Xu Lin Zhang Xiaoxin Sun Deyong Yang Shujing Wang The Roles of Glycans in Bladder Cancer Frontiers in Oncology glycans glycosyltransferases bladder cancer abnormal glycosylation biomarkers |
| title | The Roles of Glycans in Bladder Cancer |
| title_full | The Roles of Glycans in Bladder Cancer |
| title_fullStr | The Roles of Glycans in Bladder Cancer |
| title_full_unstemmed | The Roles of Glycans in Bladder Cancer |
| title_short | The Roles of Glycans in Bladder Cancer |
| title_sort | roles of glycans in bladder cancer |
| topic | glycans glycosyltransferases bladder cancer abnormal glycosylation biomarkers |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00957/full |
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