Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model.

Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model.

Cytomegalovirus (CMV) is the most common congenital infection and cause of birth defects worldwide. Primary CMV infection during pregnancy leads to a higher frequency of congenital CMV (cCMV) than maternal re-infection, suggesting that maternal immunity confers partial protection. However, poorly un...

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Bibliographic Details
Main Authors: Claire E Otero, Richard Barfield, Elizabeth Scheef, Cody S Nelson, Nicole Rodgers, Hsuan-Yuan Wang, Matilda J Moström, Tabitha D Manuel, Julian Sass, Kimberli Schmidt, Husam Taher, Courtney Papen, Lesli Sprehe, Savannah Kendall, Angel Davalos, Peter A Barry, Klaus Früh, Justin Pollara, Daniel Malouli, Cliburn Chan, Amitinder Kaur, Sallie R Permar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-10-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011378&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011378&type=printable

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