Can a specific biobehavioral-based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients? A study protocol for a randomized clinical trial.
<h4>Background</h4>Chronic pain conditions are complex multifactorial disorders with physical, psychological, and environmental factors contributing to their onset and persistence. Among these conditions, the role of brain-derived neurotrophic factor (BDNF) and the impact of a specific t...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289430&type=printable |
| _version_ | 1797347777887338496 |
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| author | Silvia Di Bonaventura Josué Fernández Carnero Raúl Ferrer-Peña |
| author_facet | Silvia Di Bonaventura Josué Fernández Carnero Raúl Ferrer-Peña |
| author_sort | Silvia Di Bonaventura |
| collection | DOAJ |
| description | <h4>Background</h4>Chronic pain conditions are complex multifactorial disorders with physical, psychological, and environmental factors contributing to their onset and persistence. Among these conditions, the role of brain-derived neurotrophic factor (BDNF) and the impact of a specific therapeutic education (TE) on pain management have emerged as important areas of research.<h4>Objective</h4>This study aims to investigate the effects of a specific type of therapeutic education on pain levels and BDNF concentrations.<h4>Methods</h4>In this single-blind, randomized clinical trial, patients will be randomly assigned to one of two groups: one will receive exercise with TE and the other without TE. Assessments will be made at baseline, mid-treatment, post-intervention, and at one and eight months.<h4>Outcomes</h4>This study will shed light on the effectiveness of a therapeutic education (TE) program in pain management. Additionally, it will provide information on its effects on BDNF levels, a biomarker of brain plasticity, as well as on various psychosocial variables that can influence pain experience.<h4>Conclusion</h4>By comprehensively addressing the need to quantify brain changes more precisely in individuals with chronic pain during interventions like TE and recognizing the importance of establishing a more structured and comprehensive protocol, this study lays a solid and replicable foundation for future evidence-based treatment developments. |
| first_indexed | 2024-03-08T11:52:42Z |
| format | Article |
| id | doaj.art-c5d625fa3c814fc6ba236680e49c6a1f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-08T11:52:42Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c5d625fa3c814fc6ba236680e49c6a1f2024-01-24T05:30:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01191e028943010.1371/journal.pone.0289430Can a specific biobehavioral-based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients? A study protocol for a randomized clinical trial.Silvia Di BonaventuraJosué Fernández CarneroRaúl Ferrer-Peña<h4>Background</h4>Chronic pain conditions are complex multifactorial disorders with physical, psychological, and environmental factors contributing to their onset and persistence. Among these conditions, the role of brain-derived neurotrophic factor (BDNF) and the impact of a specific therapeutic education (TE) on pain management have emerged as important areas of research.<h4>Objective</h4>This study aims to investigate the effects of a specific type of therapeutic education on pain levels and BDNF concentrations.<h4>Methods</h4>In this single-blind, randomized clinical trial, patients will be randomly assigned to one of two groups: one will receive exercise with TE and the other without TE. Assessments will be made at baseline, mid-treatment, post-intervention, and at one and eight months.<h4>Outcomes</h4>This study will shed light on the effectiveness of a therapeutic education (TE) program in pain management. Additionally, it will provide information on its effects on BDNF levels, a biomarker of brain plasticity, as well as on various psychosocial variables that can influence pain experience.<h4>Conclusion</h4>By comprehensively addressing the need to quantify brain changes more precisely in individuals with chronic pain during interventions like TE and recognizing the importance of establishing a more structured and comprehensive protocol, this study lays a solid and replicable foundation for future evidence-based treatment developments.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289430&type=printable |
| spellingShingle | Silvia Di Bonaventura Josué Fernández Carnero Raúl Ferrer-Peña Can a specific biobehavioral-based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients? A study protocol for a randomized clinical trial. PLoS ONE |
| title | Can a specific biobehavioral-based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients? A study protocol for a randomized clinical trial. |
| title_full | Can a specific biobehavioral-based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients? A study protocol for a randomized clinical trial. |
| title_fullStr | Can a specific biobehavioral-based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients? A study protocol for a randomized clinical trial. |
| title_full_unstemmed | Can a specific biobehavioral-based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients? A study protocol for a randomized clinical trial. |
| title_short | Can a specific biobehavioral-based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients? A study protocol for a randomized clinical trial. |
| title_sort | can a specific biobehavioral based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients a study protocol for a randomized clinical trial |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289430&type=printable |
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