To Evaluate the Effect of Edrophonium on Blood Glucose Levels in Euglycemic Albino Rats Through OGTT
Objective: To evaluate the effect of Edrophonium on blood glucose levels in euglycemic albino rats through OGTT. Materials and Methods: Twelve Swiss albino rats weighing around 150-200 gms of either sex were randomly selected from the central animal facility, JSSMC, Mysore and divided into two...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5452/11073_CE(Ra)_F(Sh)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Objective: To evaluate the effect of Edrophonium on blood
glucose levels in euglycemic albino rats through OGTT.
Materials and Methods: Twelve Swiss albino rats weighing
around 150-200 gms of either sex were randomly selected from
the central animal facility, JSSMC, Mysore and divided into two
groups. The control group received distilled water (25ml/kg
body wt.) per orally, test groups received Edrophonium (6.3mg/
kg/day) intravenously for five days. On the fifth day, following
overnight fasting, half an hour after drug administration in all
the groups of rats Oral Glucose Tolerance Test was performed,
by administering oral glucose in dose of 0.6gm/kg body weight.
The capillary blood glucose levels were measured at 0, 60
and 150 min, by rat tail snipping method using (ACCUCHEK)
glucometer.
Results: The Capillary Blood Glucose levels of Edrophonium
group was less when compared to control group at all-time
intervals.
Conclusion: Edrophonium showed the hypoglycemic activity
when given for five days intravenously in euglycemic albino rats
through Oral Glucose Tolerance Test. |
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| ISSN: | 2249-782X 0973-709X |