To Evaluate the Effect of Edrophonium on Blood Glucose Levels in Euglycemic Albino Rats Through OGTT
Objective: To evaluate the effect of Edrophonium on blood glucose levels in euglycemic albino rats through OGTT. Materials and Methods: Twelve Swiss albino rats weighing around 150-200 gms of either sex were randomly selected from the central animal facility, JSSMC, Mysore and divided into two...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2015-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/5452/11073_CE(Ra)_F(Sh)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
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| author | Siddamma Amoghimath Suresha R N Jayanthi M K Shruthi S L Vaibhavi PS Satish A M Pushpa V H Kalabharathi H L |
| author_facet | Siddamma Amoghimath Suresha R N Jayanthi M K Shruthi S L Vaibhavi PS Satish A M Pushpa V H Kalabharathi H L |
| author_sort | Siddamma Amoghimath |
| collection | DOAJ |
| description | Objective: To evaluate the effect of Edrophonium on blood
glucose levels in euglycemic albino rats through OGTT.
Materials and Methods: Twelve Swiss albino rats weighing
around 150-200 gms of either sex were randomly selected from
the central animal facility, JSSMC, Mysore and divided into two
groups. The control group received distilled water (25ml/kg
body wt.) per orally, test groups received Edrophonium (6.3mg/
kg/day) intravenously for five days. On the fifth day, following
overnight fasting, half an hour after drug administration in all
the groups of rats Oral Glucose Tolerance Test was performed,
by administering oral glucose in dose of 0.6gm/kg body weight.
The capillary blood glucose levels were measured at 0, 60
and 150 min, by rat tail snipping method using (ACCUCHEK)
glucometer.
Results: The Capillary Blood Glucose levels of Edrophonium
group was less when compared to control group at all-time
intervals.
Conclusion: Edrophonium showed the hypoglycemic activity
when given for five days intravenously in euglycemic albino rats
through Oral Glucose Tolerance Test. |
| first_indexed | 2024-12-21T14:30:28Z |
| format | Article |
| id | doaj.art-c5d8eeabcade433e8aa85c03ea0f636d |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T14:30:28Z |
| publishDate | 2015-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-c5d8eeabcade433e8aa85c03ea0f636d2022-12-21T19:00:30ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-01-0191FF04FF0710.7860/JCDR/2015/11073.5452To Evaluate the Effect of Edrophonium on Blood Glucose Levels in Euglycemic Albino Rats Through OGTTSiddamma Amoghimath0Suresha R N1Jayanthi M K2Shruthi S L3Vaibhavi PS4Satish A M5Pushpa V H6Kalabharathi H L7PG Student, Department of Pharmacology, JSS Medical College, Mysore, Karnataka, India.Professor, Department of Pharmacology, JSS Medical College, Mysore, Karnataka, India.Professor and Head, Department of Pharmacology, JSS Medical College, Mysore, Karnataka, India.PG Student, Department of Pharmacology, JSS Medical College, Mysore, Karnataka, India.PG Student, Department of Pharmacology, JSS Medical College, Mysore, Karnataka, India.Associate Professor, Department of Pharmacology, JSS Medical College, Mysore, Karnataka, India.Associate Professor, Department of Pharmacology, JSS Medical College, Mysore, Karnataka, India.Associate Professor, Department of Pharmacology, JSS Medical College, Mysore, Karnataka, India.Objective: To evaluate the effect of Edrophonium on blood glucose levels in euglycemic albino rats through OGTT. Materials and Methods: Twelve Swiss albino rats weighing around 150-200 gms of either sex were randomly selected from the central animal facility, JSSMC, Mysore and divided into two groups. The control group received distilled water (25ml/kg body wt.) per orally, test groups received Edrophonium (6.3mg/ kg/day) intravenously for five days. On the fifth day, following overnight fasting, half an hour after drug administration in all the groups of rats Oral Glucose Tolerance Test was performed, by administering oral glucose in dose of 0.6gm/kg body weight. The capillary blood glucose levels were measured at 0, 60 and 150 min, by rat tail snipping method using (ACCUCHEK) glucometer. Results: The Capillary Blood Glucose levels of Edrophonium group was less when compared to control group at all-time intervals. Conclusion: Edrophonium showed the hypoglycemic activity when given for five days intravenously in euglycemic albino rats through Oral Glucose Tolerance Test.https://jcdr.net/articles/PDF/5452/11073_CE(Ra)_F(Sh)_PF1(PAK)_PFA(AK)_PF2(PAG).pdfcapillary blood glucosediabeteseuglycemicmuscarinic agonist |
| spellingShingle | Siddamma Amoghimath Suresha R N Jayanthi M K Shruthi S L Vaibhavi PS Satish A M Pushpa V H Kalabharathi H L To Evaluate the Effect of Edrophonium on Blood Glucose Levels in Euglycemic Albino Rats Through OGTT Journal of Clinical and Diagnostic Research capillary blood glucose diabetes euglycemic muscarinic agonist |
| title | To Evaluate the Effect of Edrophonium on Blood Glucose Levels in Euglycemic Albino Rats Through OGTT |
| title_full | To Evaluate the Effect of Edrophonium on Blood Glucose Levels in Euglycemic Albino Rats Through OGTT |
| title_fullStr | To Evaluate the Effect of Edrophonium on Blood Glucose Levels in Euglycemic Albino Rats Through OGTT |
| title_full_unstemmed | To Evaluate the Effect of Edrophonium on Blood Glucose Levels in Euglycemic Albino Rats Through OGTT |
| title_short | To Evaluate the Effect of Edrophonium on Blood Glucose Levels in Euglycemic Albino Rats Through OGTT |
| title_sort | to evaluate the effect of edrophonium on blood glucose levels in euglycemic albino rats through ogtt |
| topic | capillary blood glucose diabetes euglycemic muscarinic agonist |
| url | https://jcdr.net/articles/PDF/5452/11073_CE(Ra)_F(Sh)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
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