Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance, with evidence of DM having about a three-fold risk for TB disease. TB defense may be impacted by diabetes-related e...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2023-01-01
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Series: | Frontiers in Immunology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1122255/full |
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author | Phillip Ssekamatte Obondo James Sande Reinout van Crevel Irene Andia Biraro |
author_facet | Phillip Ssekamatte Obondo James Sande Reinout van Crevel Irene Andia Biraro |
author_sort | Phillip Ssekamatte |
collection | DOAJ |
description | Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance, with evidence of DM having about a three-fold risk for TB disease. TB defense may be impacted by diabetes-related effects on immunity, metabolism, and gene transcription. An update on the epidemiological aspects of DM and TB, and the recent trends in understanding the DM-associated immunologic, metabolic, and genetic mechanisms of susceptibility to TB will be discussed in this review. This review highlights gaps in the incomplete understanding of the mechanisms that may relate to TB susceptibility in type 2 DM (T2DM). Understanding these three main domains regarding mechanisms of TB susceptibility in T2DM patients can help us build practical treatment plans to lessen the combined burden of the diseases in rampant areas. |
first_indexed | 2024-04-10T20:56:00Z |
format | Article |
id | doaj.art-c5d90679071c437682cdb59ea783740f |
institution | Directory Open Access Journal |
issn | 1664-3224 |
language | English |
last_indexed | 2024-04-10T20:56:00Z |
publishDate | 2023-01-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Immunology |
spelling | doaj.art-c5d90679071c437682cdb59ea783740f2023-01-23T04:54:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011410.3389/fimmu.2023.11222551122255Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibilityPhillip Ssekamatte0Obondo James Sande1Reinout van Crevel2Irene Andia Biraro3Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, UgandaDepartment of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, UgandaDepartment of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Internal Medicine, School of Medicine, College of Health Sciences, Makerere University, Kampala, UgandaDue to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance, with evidence of DM having about a three-fold risk for TB disease. TB defense may be impacted by diabetes-related effects on immunity, metabolism, and gene transcription. An update on the epidemiological aspects of DM and TB, and the recent trends in understanding the DM-associated immunologic, metabolic, and genetic mechanisms of susceptibility to TB will be discussed in this review. This review highlights gaps in the incomplete understanding of the mechanisms that may relate to TB susceptibility in type 2 DM (T2DM). Understanding these three main domains regarding mechanisms of TB susceptibility in T2DM patients can help us build practical treatment plans to lessen the combined burden of the diseases in rampant areas.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1122255/fulltuberculosisdiabetesimmunitymetabolismgene transcription |
spellingShingle | Phillip Ssekamatte Obondo James Sande Reinout van Crevel Irene Andia Biraro Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility Frontiers in Immunology tuberculosis diabetes immunity metabolism gene transcription |
title | Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
title_full | Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
title_fullStr | Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
title_full_unstemmed | Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
title_short | Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility |
title_sort | immunologic metabolic and genetic impact of diabetes on tuberculosis susceptibility |
topic | tuberculosis diabetes immunity metabolism gene transcription |
url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1122255/full |
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