Dairy calcium intake and lifestyle risk factors for bone loss in hiv-infected and uninfected mediterranean subjects
<p>Abstract</p> <p>Background</p> <p>Despite the reported high prevalence of osteoporosis in the human immunodeficiency virus (HIV)-population, there have been no previous studies examining dairy calcium intake and bone mineral density (BMD) in HIV-subjects.</p> &...
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| Format: | Article |
| Language: | English |
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BMC
2012-08-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://www.biomedcentral.com/1471-2334/12/192 |
| _version_ | 1818752513969487872 |
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| author | Vecchi Valentina Soresi Maurizio Giannitrapani Lydia Mazzola Giovanni La Sala Sara Tramuto Fabio Caruso Giuseppe Colomba Claudia Mansueto Pasquale Madonia Simona Montalto Giuseppe Di Carlo Paola |
| author_facet | Vecchi Valentina Soresi Maurizio Giannitrapani Lydia Mazzola Giovanni La Sala Sara Tramuto Fabio Caruso Giuseppe Colomba Claudia Mansueto Pasquale Madonia Simona Montalto Giuseppe Di Carlo Paola |
| author_sort | Vecchi Valentina |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Despite the reported high prevalence of osteoporosis in the human immunodeficiency virus (HIV)-population, there have been no previous studies examining dairy calcium intake and bone mineral density (BMD) in HIV-subjects.</p> <p>We assessed the prevalence of low BMD in HIV-infected and uninfected subjects and analyzed the effects of calcium intake, lifestyle and HIV-related risk factors on BMD.</p> <p>Methods</p> <p>One hundred and twelve HIV-infected subjects were consecutively enrolled. Seventy- six HIV-uninfected subjects matched for age and sex were enrolled as the control group. The HIV-subjects were interviewed about lifestyle habits and completed a weekly food-frequency questionnaire to estimate calcium intake. HIV-RNA, CD4+ T-cell count and data on antiretroviral therapy were also recorded. Both biochemical bone turnover markers and BMD, assessed by dual-energy radiographic absorptiometry (DXA) were recorded in the HIV-cases and controls. We also calculated the 10-year fracture risks using the WHO FRAX equation.</p> <p>Results</p> <p>Osteoporosis prevalence was significantly higher in the HIV-cases than controls (<it>p</it> < 0.05). BMI values were positively correlated with BMD (<it>p</it> < 0.05). Vitamin D levels were lower in the HIV-subjects (<it>p</it> < 0.02). No correlation was found with daily calcium intake.</p> <p>BMI values were significantly correlated with dairy intake quartiles (<it>p</it> < 0.003). In HIV-subjects, the mean of FRAX score was 1.2 % for hip and 4.7 % for major osteoporotic fractures. On multivariate analysis of the lumbar spine DXA T-score, age (<it>p</it> < 0.005) and HIV/hepatitis C virus co-infection (<it>p</it> < 0.0001) were negatively correlated with BMD, while yogurt intake was a protective predictor of BMD (<it>p</it> < 0.05). In the femur DXA T-score, age (<it>p</it> < 0.01), nadir CD4 + T-cell count < 200 cells/μL (<it>p</it> < 0.05) and drug addiction ( <it>p</it> < 0.0001) were negatively correlated with BMD.</p> <p>Conclusions</p> <p>Among the foods rich in calcium, yogurt was a protective predictor of BMD in HIV-subjects. HIV/HCV co-infection, nadir CD4 + T-cell count < 200 cells/μL and drug addiction were independent predictors of severe BMD. Promoting behavioral changes in food intake and lifestyle, aimed at the primary prevention of bone disease in the chronically-infected subjects seems to be essential for implementing medical intervention in these cases.</p> |
| first_indexed | 2024-12-18T04:52:40Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-18T04:52:40Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-c5d9a2d551fb4e1db98b54b72ada91c92022-12-21T21:20:23ZengBMCBMC Infectious Diseases1471-23342012-08-0112119210.1186/1471-2334-12-192Dairy calcium intake and lifestyle risk factors for bone loss in hiv-infected and uninfected mediterranean subjectsVecchi ValentinaSoresi MaurizioGiannitrapani LydiaMazzola GiovanniLa Sala SaraTramuto FabioCaruso GiuseppeColomba ClaudiaMansueto PasqualeMadonia SimonaMontalto GiuseppeDi Carlo Paola<p>Abstract</p> <p>Background</p> <p>Despite the reported high prevalence of osteoporosis in the human immunodeficiency virus (HIV)-population, there have been no previous studies examining dairy calcium intake and bone mineral density (BMD) in HIV-subjects.</p> <p>We assessed the prevalence of low BMD in HIV-infected and uninfected subjects and analyzed the effects of calcium intake, lifestyle and HIV-related risk factors on BMD.</p> <p>Methods</p> <p>One hundred and twelve HIV-infected subjects were consecutively enrolled. Seventy- six HIV-uninfected subjects matched for age and sex were enrolled as the control group. The HIV-subjects were interviewed about lifestyle habits and completed a weekly food-frequency questionnaire to estimate calcium intake. HIV-RNA, CD4+ T-cell count and data on antiretroviral therapy were also recorded. Both biochemical bone turnover markers and BMD, assessed by dual-energy radiographic absorptiometry (DXA) were recorded in the HIV-cases and controls. We also calculated the 10-year fracture risks using the WHO FRAX equation.</p> <p>Results</p> <p>Osteoporosis prevalence was significantly higher in the HIV-cases than controls (<it>p</it> < 0.05). BMI values were positively correlated with BMD (<it>p</it> < 0.05). Vitamin D levels were lower in the HIV-subjects (<it>p</it> < 0.02). No correlation was found with daily calcium intake.</p> <p>BMI values were significantly correlated with dairy intake quartiles (<it>p</it> < 0.003). In HIV-subjects, the mean of FRAX score was 1.2 % for hip and 4.7 % for major osteoporotic fractures. On multivariate analysis of the lumbar spine DXA T-score, age (<it>p</it> < 0.005) and HIV/hepatitis C virus co-infection (<it>p</it> < 0.0001) were negatively correlated with BMD, while yogurt intake was a protective predictor of BMD (<it>p</it> < 0.05). In the femur DXA T-score, age (<it>p</it> < 0.01), nadir CD4 + T-cell count < 200 cells/μL (<it>p</it> < 0.05) and drug addiction ( <it>p</it> < 0.0001) were negatively correlated with BMD.</p> <p>Conclusions</p> <p>Among the foods rich in calcium, yogurt was a protective predictor of BMD in HIV-subjects. HIV/HCV co-infection, nadir CD4 + T-cell count < 200 cells/μL and drug addiction were independent predictors of severe BMD. Promoting behavioral changes in food intake and lifestyle, aimed at the primary prevention of bone disease in the chronically-infected subjects seems to be essential for implementing medical intervention in these cases.</p>http://www.biomedcentral.com/1471-2334/12/192HIVOsteopeniaOsteoporosisDairy intakeBone mineral density |
| spellingShingle | Vecchi Valentina Soresi Maurizio Giannitrapani Lydia Mazzola Giovanni La Sala Sara Tramuto Fabio Caruso Giuseppe Colomba Claudia Mansueto Pasquale Madonia Simona Montalto Giuseppe Di Carlo Paola Dairy calcium intake and lifestyle risk factors for bone loss in hiv-infected and uninfected mediterranean subjects BMC Infectious Diseases HIV Osteopenia Osteoporosis Dairy intake Bone mineral density |
| title | Dairy calcium intake and lifestyle risk factors for bone loss in hiv-infected and uninfected mediterranean subjects |
| title_full | Dairy calcium intake and lifestyle risk factors for bone loss in hiv-infected and uninfected mediterranean subjects |
| title_fullStr | Dairy calcium intake and lifestyle risk factors for bone loss in hiv-infected and uninfected mediterranean subjects |
| title_full_unstemmed | Dairy calcium intake and lifestyle risk factors for bone loss in hiv-infected and uninfected mediterranean subjects |
| title_short | Dairy calcium intake and lifestyle risk factors for bone loss in hiv-infected and uninfected mediterranean subjects |
| title_sort | dairy calcium intake and lifestyle risk factors for bone loss in hiv infected and uninfected mediterranean subjects |
| topic | HIV Osteopenia Osteoporosis Dairy intake Bone mineral density |
| url | http://www.biomedcentral.com/1471-2334/12/192 |
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