Fatty Acid-Binding Protein 5 Gene Deletion Enhances Nicotine-Conditioned Place Preference: Illuminating the Putative Gateway Mechanisms
Emerging evidence indicates that the endogenous cannabinoid system modulates the behavioral and physiological effects of nicotine. Fatty acid-binding proteins (FABPs) are among the primary intracellular trafficking mechanisms of endogenous cannabinoids, such as anandamide. To this end, changes in FA...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Future Pharmacology |
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| Online Access: | https://www.mdpi.com/2673-9879/3/1/7 |
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| author | Nicole Roeder Brittany Richardson Abrianna Mihalkovic Samantha Penman Olivia White John Hamilton Ashim Gupta Kenneth Blum Mark S. Gold Panayotis K. Thanos |
| author_facet | Nicole Roeder Brittany Richardson Abrianna Mihalkovic Samantha Penman Olivia White John Hamilton Ashim Gupta Kenneth Blum Mark S. Gold Panayotis K. Thanos |
| author_sort | Nicole Roeder |
| collection | DOAJ |
| description | Emerging evidence indicates that the endogenous cannabinoid system modulates the behavioral and physiological effects of nicotine. Fatty acid-binding proteins (FABPs) are among the primary intracellular trafficking mechanisms of endogenous cannabinoids, such as anandamide. To this end, changes in FABP expression may similarly impact the behavioral manifestations associated with nicotine, particularly its addictive properties. <i>FABP5<sup>+/+</sup></i> and <i>FABP5<sup>−/−</sup></i> mice were tested for nicotine-conditioned place preference (CPP) at two different doses (0.1 or 0.5 mg/kg). The nicotine-paired chamber was assigned as their least preferred chamber during preconditioning. Following 8 days of conditioning, the mice were injected with either nicotine or saline. The mice were allowed to access to all the chambers on the test day, and their times spent in the drug chamber on the preconditioning versus the test days were used to examine the drug preference score. The CPP results showed that the <i>FABP5<sup>−/−</sup></i> mice displayed a higher place preference for 0.1 mg/kg nicotine than the <i>FABP5<sup>+/+</sup></i> mice, while no CPP difference was observed for 0.5 mg/kg nicotine between the genotypes. In conclusion, <i>FABP5</i> plays an important role in regulating nicotine place preference. Further research is warranted to identify the precise mechanisms. The results suggest that dysregulated cannabinoid signaling may impact nicotine-seeking behavior. |
| first_indexed | 2024-03-11T06:31:24Z |
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| institution | Directory Open Access Journal |
| issn | 2673-9879 |
| language | English |
| last_indexed | 2024-03-11T06:31:24Z |
| publishDate | 2023-01-01 |
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| series | Future Pharmacology |
| spelling | doaj.art-c5d9fdcc2d13432fb1776289d6aa41022023-11-17T11:13:25ZengMDPI AGFuture Pharmacology2673-98792023-01-013110811610.3390/futurepharmacol3010007Fatty Acid-Binding Protein 5 Gene Deletion Enhances Nicotine-Conditioned Place Preference: Illuminating the Putative Gateway MechanismsNicole Roeder0Brittany Richardson1Abrianna Mihalkovic2Samantha Penman3Olivia White4John Hamilton5Ashim Gupta6Kenneth Blum7Mark S. Gold8Panayotis K. Thanos9Behavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USABehavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USABehavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USABehavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USABehavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USABehavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USAFuture Biologics, Lawrenceville, GA 30043, USADivision of Addiction Research & Education, Center for Mental Health & Sports, Exercise and Global Mental Health, Western University Health Sciences, Pomona, CA 91766, USADepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USABehavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USAEmerging evidence indicates that the endogenous cannabinoid system modulates the behavioral and physiological effects of nicotine. Fatty acid-binding proteins (FABPs) are among the primary intracellular trafficking mechanisms of endogenous cannabinoids, such as anandamide. To this end, changes in FABP expression may similarly impact the behavioral manifestations associated with nicotine, particularly its addictive properties. <i>FABP5<sup>+/+</sup></i> and <i>FABP5<sup>−/−</sup></i> mice were tested for nicotine-conditioned place preference (CPP) at two different doses (0.1 or 0.5 mg/kg). The nicotine-paired chamber was assigned as their least preferred chamber during preconditioning. Following 8 days of conditioning, the mice were injected with either nicotine or saline. The mice were allowed to access to all the chambers on the test day, and their times spent in the drug chamber on the preconditioning versus the test days were used to examine the drug preference score. The CPP results showed that the <i>FABP5<sup>−/−</sup></i> mice displayed a higher place preference for 0.1 mg/kg nicotine than the <i>FABP5<sup>+/+</sup></i> mice, while no CPP difference was observed for 0.5 mg/kg nicotine between the genotypes. In conclusion, <i>FABP5</i> plays an important role in regulating nicotine place preference. Further research is warranted to identify the precise mechanisms. The results suggest that dysregulated cannabinoid signaling may impact nicotine-seeking behavior.https://www.mdpi.com/2673-9879/3/1/7nicotineconditioned place preferencefatty acid-binding protein 5endocannabinoidscannabinoid receptor 1dopamine |
| spellingShingle | Nicole Roeder Brittany Richardson Abrianna Mihalkovic Samantha Penman Olivia White John Hamilton Ashim Gupta Kenneth Blum Mark S. Gold Panayotis K. Thanos Fatty Acid-Binding Protein 5 Gene Deletion Enhances Nicotine-Conditioned Place Preference: Illuminating the Putative Gateway Mechanisms Future Pharmacology nicotine conditioned place preference fatty acid-binding protein 5 endocannabinoids cannabinoid receptor 1 dopamine |
| title | Fatty Acid-Binding Protein 5 Gene Deletion Enhances Nicotine-Conditioned Place Preference: Illuminating the Putative Gateway Mechanisms |
| title_full | Fatty Acid-Binding Protein 5 Gene Deletion Enhances Nicotine-Conditioned Place Preference: Illuminating the Putative Gateway Mechanisms |
| title_fullStr | Fatty Acid-Binding Protein 5 Gene Deletion Enhances Nicotine-Conditioned Place Preference: Illuminating the Putative Gateway Mechanisms |
| title_full_unstemmed | Fatty Acid-Binding Protein 5 Gene Deletion Enhances Nicotine-Conditioned Place Preference: Illuminating the Putative Gateway Mechanisms |
| title_short | Fatty Acid-Binding Protein 5 Gene Deletion Enhances Nicotine-Conditioned Place Preference: Illuminating the Putative Gateway Mechanisms |
| title_sort | fatty acid binding protein 5 gene deletion enhances nicotine conditioned place preference illuminating the putative gateway mechanisms |
| topic | nicotine conditioned place preference fatty acid-binding protein 5 endocannabinoids cannabinoid receptor 1 dopamine |
| url | https://www.mdpi.com/2673-9879/3/1/7 |
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