Lipid Nanoparticles-Based Therapy in Liver Metastasis Management: From Tumor Cell-Directed Strategy to Liver Microenvironment-Directed Strategy
Yuhan Wang,1 Zhenyu Yin,1 Lei Gao,1 Bin Ma,1 Jianming Shi,1 Hao Chen2 1Lanzhou University Second Hospital, Lanzhou, 730030, People’s Republic of China; 2Department of Surgical Oncology, Key Laboratory of the Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, 7300...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-06-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/lipid-nanoparticles-based-therapy-in-liver-metastasis-management-from--peer-reviewed-fulltext-article-IJN |
| _version_ | 1797810006446309376 |
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| author | Wang Y Yin Z Gao L Ma B Shi J Chen H |
| author_facet | Wang Y Yin Z Gao L Ma B Shi J Chen H |
| author_sort | Wang Y |
| collection | DOAJ |
| description | Yuhan Wang,1 Zhenyu Yin,1 Lei Gao,1 Bin Ma,1 Jianming Shi,1 Hao Chen2 1Lanzhou University Second Hospital, Lanzhou, 730030, People’s Republic of China; 2Department of Surgical Oncology, Key Laboratory of the Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu Province, People’s Republic of ChinaCorrespondence: Hao Chen, Tel +8615009467790, Fax +8609315109551, Email ery_chenh@lzu.edu.cnAbstract: Metastasis to the liver, as one of the most frequent metastatic patterns, was associated with poor prognosis. Major drawbacks of conventional therapies in liver metastasis were the lack of metastatic-targeting ability, predominant systemic toxicities and incapability of tumor microenvironment modulations. Lipid nanoparticles-based strategies like galactosylated, lyso-thermosensitive or active-targeting chemotherapeutics liposomes have been explored in liver metastasis management. This review aimed to summarize the state-of-art lipid nanoparticles-based therapies in liver metastasis management. Clinical and translational studies on the lipid nanoparticles in treating liver metastasis were searched up to April, 2023 from online databases. This review focused not only on the updates in drug-encapsulated lipid nanoparticles directly targeting metastatic cancer cells in treating liver metastasis, but more importantly on research frontiers in drug-loading lipid nanoparticles targeting nonparenchymal liver tumor microenvironment components in treating liver metastasis, which showed promise for future clinical oncological practice.Keywords: liver neoplasms, neoplasm metastasis, liposomes, tumor microenvironment |
| first_indexed | 2024-03-13T07:01:34Z |
| format | Article |
| id | doaj.art-c5dc5655d3554af796f0b42ca95be70a |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-03-13T07:01:34Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-c5dc5655d3554af796f0b42ca95be70a2023-06-06T19:22:44ZengDove Medical PressInternational Journal of Nanomedicine1178-20132023-06-01Volume 182939295484164Lipid Nanoparticles-Based Therapy in Liver Metastasis Management: From Tumor Cell-Directed Strategy to Liver Microenvironment-Directed StrategyWang YYin ZGao LMa BShi JChen HYuhan Wang,1 Zhenyu Yin,1 Lei Gao,1 Bin Ma,1 Jianming Shi,1 Hao Chen2 1Lanzhou University Second Hospital, Lanzhou, 730030, People’s Republic of China; 2Department of Surgical Oncology, Key Laboratory of the Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu Province, People’s Republic of ChinaCorrespondence: Hao Chen, Tel +8615009467790, Fax +8609315109551, Email ery_chenh@lzu.edu.cnAbstract: Metastasis to the liver, as one of the most frequent metastatic patterns, was associated with poor prognosis. Major drawbacks of conventional therapies in liver metastasis were the lack of metastatic-targeting ability, predominant systemic toxicities and incapability of tumor microenvironment modulations. Lipid nanoparticles-based strategies like galactosylated, lyso-thermosensitive or active-targeting chemotherapeutics liposomes have been explored in liver metastasis management. This review aimed to summarize the state-of-art lipid nanoparticles-based therapies in liver metastasis management. Clinical and translational studies on the lipid nanoparticles in treating liver metastasis were searched up to April, 2023 from online databases. This review focused not only on the updates in drug-encapsulated lipid nanoparticles directly targeting metastatic cancer cells in treating liver metastasis, but more importantly on research frontiers in drug-loading lipid nanoparticles targeting nonparenchymal liver tumor microenvironment components in treating liver metastasis, which showed promise for future clinical oncological practice.Keywords: liver neoplasms, neoplasm metastasis, liposomes, tumor microenvironmenthttps://www.dovepress.com/lipid-nanoparticles-based-therapy-in-liver-metastasis-management-from--peer-reviewed-fulltext-article-IJNliver neoplasmsneoplasm metastasisliposomestumor microenvironment |
| spellingShingle | Wang Y Yin Z Gao L Ma B Shi J Chen H Lipid Nanoparticles-Based Therapy in Liver Metastasis Management: From Tumor Cell-Directed Strategy to Liver Microenvironment-Directed Strategy International Journal of Nanomedicine liver neoplasms neoplasm metastasis liposomes tumor microenvironment |
| title | Lipid Nanoparticles-Based Therapy in Liver Metastasis Management: From Tumor Cell-Directed Strategy to Liver Microenvironment-Directed Strategy |
| title_full | Lipid Nanoparticles-Based Therapy in Liver Metastasis Management: From Tumor Cell-Directed Strategy to Liver Microenvironment-Directed Strategy |
| title_fullStr | Lipid Nanoparticles-Based Therapy in Liver Metastasis Management: From Tumor Cell-Directed Strategy to Liver Microenvironment-Directed Strategy |
| title_full_unstemmed | Lipid Nanoparticles-Based Therapy in Liver Metastasis Management: From Tumor Cell-Directed Strategy to Liver Microenvironment-Directed Strategy |
| title_short | Lipid Nanoparticles-Based Therapy in Liver Metastasis Management: From Tumor Cell-Directed Strategy to Liver Microenvironment-Directed Strategy |
| title_sort | lipid nanoparticles based therapy in liver metastasis management from tumor cell directed strategy to liver microenvironment directed strategy |
| topic | liver neoplasms neoplasm metastasis liposomes tumor microenvironment |
| url | https://www.dovepress.com/lipid-nanoparticles-based-therapy-in-liver-metastasis-management-from--peer-reviewed-fulltext-article-IJN |
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