Association of UGT1A1 gene variants, expression levels, and enzyme concentrations with 2,3,7,8-TCDD exposure in individuals exposed to Agent Orange/Dioxin

Association of UGT1A1 gene variants, expression levels, and enzyme concentrations with 2,3,7,8-TCDD exposure in individuals exposed to Agent Orange/Dioxin

Abstract Among the congener of dioxin, 2,3,7,8-TCDD is the most toxic, having a serious long-term impact on the environment and human health. UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a crucial role in the detoxification and excretion of endogenous and exogenous lipophilic compounds, primarily...

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Bibliographic Details
Main Authors: Ha Van Quang, Nguyen Ba Vuong, Bui Ngoc Linh Trang, Nguyen Linh Toan, Hoang Van Tong
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Agent Orange/Dioxin
2,3,7,8-TCDD
UGT1A1 enzyme
UGT1A1 gene polymorphism
Online Access:https://doi.org/10.1038/s41598-024-54004-0

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