Feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1 are involved in arsenite-induced cell malignant transformation.

Feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1 are involved in arsenite-induced cell malignant transformation.

OBJECTIVE: To establish the functions of miR-21 and the roles of two feedback regulation loops, miR-21-Spry1-ERK/NF-κB and miR-21-Pdcd4-JNK/c-Jun, in arsenite-transformed human embryo lung fibroblast (HELF) cells. METHODS: For arsenite-transformed HELF cells, apoptosis, clonogenicity, and capacity f...

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Bibliographic Details
Main Authors: Lu Shen, Min Ling, Yuan Li, Yuan Xu, Yun Zhou, Jing Ye, Ying Pang, Yue Zhao, Rongrong Jiang, Jianping Zhang, Qizhan Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3585869?pdf=render

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