Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats
Abstract Aim Obesity during pregnancy is one of the most established risk factors for negative long-term programming. The aim of the present study was to investigate the effects of maternal consumption of a high-fat diet during pregnancy and lactation on the weight gain, visceral adipose tissue and...
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| Format: | Article |
| Language: | English |
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Instituto Internacional de Ecologia
2018-01-01
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| Series: | Brazilian Journal of Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842018005001103&lng=en&tlng=en |
| _version_ | 1819210149887213568 |
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| author | M. S. Lima G. S. Perez G. L. Morais L. S. Santos G. S. Cordeiro R. D. Couto T. C. B. J. Deiró C. G. Leandro J. M. Barreto-Medeiros |
| author_facet | M. S. Lima G. S. Perez G. L. Morais L. S. Santos G. S. Cordeiro R. D. Couto T. C. B. J. Deiró C. G. Leandro J. M. Barreto-Medeiros |
| author_sort | M. S. Lima |
| collection | DOAJ |
| description | Abstract Aim Obesity during pregnancy is one of the most established risk factors for negative long-term programming. The aim of the present study was to investigate the effects of maternal consumption of a high-fat diet during pregnancy and lactation on the weight gain, visceral adipose tissue and cholesterolemia in neonatal rats. Methods Wistar rats were divided into two groups according to the mother's diet during pregnancy and lactation: Control group (CG, n = 12) were the offspring of rats fed a standard diet (4% lipid) and the Test group (TG, n = 12) were pups rats fed on a high fat diet (23% lipid). The weight of the animals was measured on alternate days until the 22nd day of life, when collected visceral adipose tissue and blood were collected for biochemical analysis. For statistical analysis the Student t test, Sidak´s teste and two way ANOVA was used, with p <0.05. Results the test group showed differences in weight gain, visceral adipose tissue and higher cholesterol. Conclusion a maternal exposure to a high-fat diet during pregnancy and lactation can promote changes in weight gain, hypercholesterolemia and an increase in adipose tissue in neonatal rats. |
| first_indexed | 2024-12-23T06:06:36Z |
| format | Article |
| id | doaj.art-c5dd13e5e7d147668e0d6fe04ba0929a |
| institution | Directory Open Access Journal |
| issn | 1678-4375 |
| language | English |
| last_indexed | 2024-12-23T06:06:36Z |
| publishDate | 2018-01-01 |
| publisher | Instituto Internacional de Ecologia |
| record_format | Article |
| series | Brazilian Journal of Biology |
| spelling | doaj.art-c5dd13e5e7d147668e0d6fe04ba0929a2022-12-21T17:57:33ZengInstituto Internacional de EcologiaBrazilian Journal of Biology1678-43752018-01-01010.1590/1519-6984.166788S1519-69842018005001103Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal ratsM. S. LimaG. S. PerezG. L. MoraisL. S. SantosG. S. CordeiroR. D. CoutoT. C. B. J. DeiróC. G. LeandroJ. M. Barreto-MedeirosAbstract Aim Obesity during pregnancy is one of the most established risk factors for negative long-term programming. The aim of the present study was to investigate the effects of maternal consumption of a high-fat diet during pregnancy and lactation on the weight gain, visceral adipose tissue and cholesterolemia in neonatal rats. Methods Wistar rats were divided into two groups according to the mother's diet during pregnancy and lactation: Control group (CG, n = 12) were the offspring of rats fed a standard diet (4% lipid) and the Test group (TG, n = 12) were pups rats fed on a high fat diet (23% lipid). The weight of the animals was measured on alternate days until the 22nd day of life, when collected visceral adipose tissue and blood were collected for biochemical analysis. For statistical analysis the Student t test, Sidak´s teste and two way ANOVA was used, with p <0.05. Results the test group showed differences in weight gain, visceral adipose tissue and higher cholesterol. Conclusion a maternal exposure to a high-fat diet during pregnancy and lactation can promote changes in weight gain, hypercholesterolemia and an increase in adipose tissue in neonatal rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842018005001103&lng=en&tlng=endieta hiperlipídicaratos neonatoscolesteroltecido adiposo visceral |
| spellingShingle | M. S. Lima G. S. Perez G. L. Morais L. S. Santos G. S. Cordeiro R. D. Couto T. C. B. J. Deiró C. G. Leandro J. M. Barreto-Medeiros Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats Brazilian Journal of Biology dieta hiperlipídica ratos neonatos colesterol tecido adiposo visceral |
| title | Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats |
| title_full | Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats |
| title_fullStr | Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats |
| title_full_unstemmed | Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats |
| title_short | Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats |
| title_sort | effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats |
| topic | dieta hiperlipídica ratos neonatos colesterol tecido adiposo visceral |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842018005001103&lng=en&tlng=en |
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