Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal
Many adult organs including Drosophila adult midguts rely on resident stem cells to replenish damaged cells during tissue homeostasis and regeneration. Previous studies have shown that, upon injury, intestinal stem cells (ISCs) in the midguts can increase proliferation and lineage differentiation to...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-10-01
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| Series: | Fly |
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| Online Access: | http://dx.doi.org/10.1080/19336934.2017.1384104 |
| _version_ | 1827810974984306688 |
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| author | Aiguo Tian Jin Jiang |
| author_facet | Aiguo Tian Jin Jiang |
| author_sort | Aiguo Tian |
| collection | DOAJ |
| description | Many adult organs including Drosophila adult midguts rely on resident stem cells to replenish damaged cells during tissue homeostasis and regeneration. Previous studies have shown that, upon injury, intestinal stem cells (ISCs) in the midguts can increase proliferation and lineage differentiation to meet the demand for tissue repair. Our recent study has demonstrated that, in response to certain injury, midguts can expand ISC population size as an additional regenerative mechanism. We found that injury elicited by bleomycin feeding or bacterial infection increased the production of two BMP ligands (Dpp and Gbb) in enterocytes (ECs), leading to elevated BMP signaling in progenitor cells that drove an expansion of ISCs by promoting their symmetric self-renewing division. Interestingly, we also found that BMP signaling in ECs inhibits the production of Dpp and Gbb, and that this negative feedback mechanism is required to reset ISC pool size to the homeostatic state. Our findings suggest that BMP signaling exerts two opposing influences on stem cell activity depending on where it acts: BMP signaling in progenitor cells promotes ISC self-renewal while BMP signaling in ECs restricts ISC self-renewal by preventing excessive production of BMP ligands. Our results further suggest that transient expansion of ISC population in conjunction with increasing ISC proliferation provides a more effective strategy for tissue regeneration. |
| first_indexed | 2024-03-11T22:58:55Z |
| format | Article |
| id | doaj.art-c5dda27d3b1746ca8a279753839dbe10 |
| institution | Directory Open Access Journal |
| issn | 1933-6934 1933-6942 |
| language | English |
| last_indexed | 2024-03-11T22:58:55Z |
| publishDate | 2017-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Fly |
| spelling | doaj.art-c5dda27d3b1746ca8a279753839dbe102023-09-21T15:09:08ZengTaylor & Francis GroupFly1933-69341933-69422017-10-0111429730210.1080/19336934.2017.13841041384104Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewalAiguo Tian0Jin Jiang1University of Texas Southwestern Medical Center at DallasUniversity of Texas Southwestern Medical Center at DallasMany adult organs including Drosophila adult midguts rely on resident stem cells to replenish damaged cells during tissue homeostasis and regeneration. Previous studies have shown that, upon injury, intestinal stem cells (ISCs) in the midguts can increase proliferation and lineage differentiation to meet the demand for tissue repair. Our recent study has demonstrated that, in response to certain injury, midguts can expand ISC population size as an additional regenerative mechanism. We found that injury elicited by bleomycin feeding or bacterial infection increased the production of two BMP ligands (Dpp and Gbb) in enterocytes (ECs), leading to elevated BMP signaling in progenitor cells that drove an expansion of ISCs by promoting their symmetric self-renewing division. Interestingly, we also found that BMP signaling in ECs inhibits the production of Dpp and Gbb, and that this negative feedback mechanism is required to reset ISC pool size to the homeostatic state. Our findings suggest that BMP signaling exerts two opposing influences on stem cell activity depending on where it acts: BMP signaling in progenitor cells promotes ISC self-renewal while BMP signaling in ECs restricts ISC self-renewal by preventing excessive production of BMP ligands. Our results further suggest that transient expansion of ISC population in conjunction with increasing ISC proliferation provides a more effective strategy for tissue regeneration.http://dx.doi.org/10.1080/19336934.2017.1384104adult stem cellasymmetric divisionbmpdifferentiationdppgbbinjuryiscmidgutnnicheproliferationregenerationself-renewalsignalingsmadsymmetric division |
| spellingShingle | Aiguo Tian Jin Jiang Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal Fly adult stem cell asymmetric division bmp differentiation dpp gbb injury isc midgut n niche proliferation regeneration self-renewal signaling smad symmetric division |
| title | Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal |
| title_full | Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal |
| title_fullStr | Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal |
| title_full_unstemmed | Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal |
| title_short | Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal |
| title_sort | dual role of bmp signaling in the regulation of drosophila intestinal stem cell self renewal |
| topic | adult stem cell asymmetric division bmp differentiation dpp gbb injury isc midgut n niche proliferation regeneration self-renewal signaling smad symmetric division |
| url | http://dx.doi.org/10.1080/19336934.2017.1384104 |
| work_keys_str_mv | AT aiguotian dualroleofbmpsignalingintheregulationofdrosophilaintestinalstemcellselfrenewal AT jinjiang dualroleofbmpsignalingintheregulationofdrosophilaintestinalstemcellselfrenewal |