Host mitochondria: more than an organelle in SARS-CoV-2 infection
Since December 2019, the world has been facing viral pandemic called COVID-19 (Coronavirus disease 2019) caused by a new beta-coronavirus named severe acute respiratory syndrome coronavirus-2, or SARS-CoV-2. COVID-19 patients may present with a wide range of symptoms, from asymptomatic to requiring...
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Format: | Article |
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Frontiers Media S.A.
2023-08-01
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Series: | Frontiers in Cellular and Infection Microbiology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1228275/full |
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author | Shahrzad Shoraka Shahrzad Shoraka Amali E. Samarasinghe Amali E. Samarasinghe Amir Ghaemi Seyed Reza Mohebbi |
author_facet | Shahrzad Shoraka Shahrzad Shoraka Amali E. Samarasinghe Amali E. Samarasinghe Amir Ghaemi Seyed Reza Mohebbi |
author_sort | Shahrzad Shoraka |
collection | DOAJ |
description | Since December 2019, the world has been facing viral pandemic called COVID-19 (Coronavirus disease 2019) caused by a new beta-coronavirus named severe acute respiratory syndrome coronavirus-2, or SARS-CoV-2. COVID-19 patients may present with a wide range of symptoms, from asymptomatic to requiring intensive care support. The severe form of COVID-19 is often marked by an altered immune response and cytokine storm. Advanced age, age-related and underlying diseases, including metabolic syndromes, appear to contribute to increased COVID-19 severity and mortality suggesting a role for mitochondria in disease pathogenesis. Furthermore, since the immune system is associated with mitochondria and its damage-related molecular patterns (mtDAMPs), the host mitochondrial system may play an important role during viral infections. Viruses have evolved to modulate the immune system and mitochondrial function for survival and proliferation, which in turn could lead to cellular stress and contribute to disease progression. Recent studies have focused on the possible roles of mitochondria in SARS-CoV-2 infection. It has been suggested that mitochondrial hijacking by SARS-CoV-2 could be a key factor in COVID-19 pathogenesis. In this review, we discuss the roles of mitochondria in viral infections including SARS-CoV-2 infection based on past and present knowledge. Paying attention to the role of mitochondria in SARS-CoV-2 infection will help to better understand the pathophysiology of COVID-19 and to achieve effective methods of prevention, diagnosis, and treatment. |
first_indexed | 2024-03-12T13:22:41Z |
format | Article |
id | doaj.art-c5de2232bce1433896f6ff83aef68508 |
institution | Directory Open Access Journal |
issn | 2235-2988 |
language | English |
last_indexed | 2024-03-12T13:22:41Z |
publishDate | 2023-08-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Cellular and Infection Microbiology |
spelling | doaj.art-c5de2232bce1433896f6ff83aef685082023-08-25T18:15:51ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-08-011310.3389/fcimb.2023.12282751228275Host mitochondria: more than an organelle in SARS-CoV-2 infectionShahrzad Shoraka0Shahrzad Shoraka1Amali E. Samarasinghe2Amali E. Samarasinghe3Amir Ghaemi4Seyed Reza Mohebbi5Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, IranDivision of Pulmonology, Allergy and Immunology, Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, United StatesChildren’s Foundation Research Institute, Memphis, TN, United StatesDepartment of Virology, Pasteur Institute of Iran, Tehran, IranGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, IranSince December 2019, the world has been facing viral pandemic called COVID-19 (Coronavirus disease 2019) caused by a new beta-coronavirus named severe acute respiratory syndrome coronavirus-2, or SARS-CoV-2. COVID-19 patients may present with a wide range of symptoms, from asymptomatic to requiring intensive care support. The severe form of COVID-19 is often marked by an altered immune response and cytokine storm. Advanced age, age-related and underlying diseases, including metabolic syndromes, appear to contribute to increased COVID-19 severity and mortality suggesting a role for mitochondria in disease pathogenesis. Furthermore, since the immune system is associated with mitochondria and its damage-related molecular patterns (mtDAMPs), the host mitochondrial system may play an important role during viral infections. Viruses have evolved to modulate the immune system and mitochondrial function for survival and proliferation, which in turn could lead to cellular stress and contribute to disease progression. Recent studies have focused on the possible roles of mitochondria in SARS-CoV-2 infection. It has been suggested that mitochondrial hijacking by SARS-CoV-2 could be a key factor in COVID-19 pathogenesis. In this review, we discuss the roles of mitochondria in viral infections including SARS-CoV-2 infection based on past and present knowledge. Paying attention to the role of mitochondria in SARS-CoV-2 infection will help to better understand the pathophysiology of COVID-19 and to achieve effective methods of prevention, diagnosis, and treatment.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1228275/fullcoronavirusSARS-CoV-2COVID-19mitochondriaviral infection |
spellingShingle | Shahrzad Shoraka Shahrzad Shoraka Amali E. Samarasinghe Amali E. Samarasinghe Amir Ghaemi Seyed Reza Mohebbi Host mitochondria: more than an organelle in SARS-CoV-2 infection Frontiers in Cellular and Infection Microbiology coronavirus SARS-CoV-2 COVID-19 mitochondria viral infection |
title | Host mitochondria: more than an organelle in SARS-CoV-2 infection |
title_full | Host mitochondria: more than an organelle in SARS-CoV-2 infection |
title_fullStr | Host mitochondria: more than an organelle in SARS-CoV-2 infection |
title_full_unstemmed | Host mitochondria: more than an organelle in SARS-CoV-2 infection |
title_short | Host mitochondria: more than an organelle in SARS-CoV-2 infection |
title_sort | host mitochondria more than an organelle in sars cov 2 infection |
topic | coronavirus SARS-CoV-2 COVID-19 mitochondria viral infection |
url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1228275/full |
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