Prognostic nutritional index before surgical treatment may serve as a prognostic biomarker for patients with upper tract urothelial carcinoma: A systematic review and meta-analysis
ObjectiveThis meta-analysis aims to assess whether the prognostic nutritional index (PNI) score before treatment can be an independent biomarker of the prognosis of patients with upper tract urothelial carcinoma (UTUC).Materials and methodsWe systematically search PubMed, Embase, Scopus database, an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.972034/full |
| _version_ | 1798001494146940928 |
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| author | Chunyang Meng Lijian Gan Kangsen Li Fulin Yi Lei Peng Jinze Li Yunxiang Li |
| author_facet | Chunyang Meng Lijian Gan Kangsen Li Fulin Yi Lei Peng Jinze Li Yunxiang Li |
| author_sort | Chunyang Meng |
| collection | DOAJ |
| description | ObjectiveThis meta-analysis aims to assess whether the prognostic nutritional index (PNI) score before treatment can be an independent biomarker of the prognosis of patients with upper tract urothelial carcinoma (UTUC).Materials and methodsWe systematically search PubMed, Embase, Scopus database, and Cochrane Library, and the search time is up to April 2021. Use STATA 16.0 software for data processing and statistical analysis.ResultsSix studies, including seven cohorts, were eventually included in our meta-analysis. The meta-analysis results showed that low PNI scores are associated with worse OS (HR: 1.92; 95% CI 1.60 to 2.30; P < 0.01), DFS/RFS/PFS (HR: 1.57; 95% CI 1.33 to 1.85; P < 0.01), and CSS/DSS (HR: 1.79; 95% CI 1.49 to 2.16; P < 0.01), which supported the PNI score as an independent prognostic biomarker for survival outcomes. The subgroup analysis and Begg’s test showed that the results were stable.ConclusionBased on current evidence, this meta-analysis proves that the PNI score of UTUC patients before treatment is an independent prognostic biomarker. It performs well on OS, DFS/RFS/PFS, and CSS/DSS. This conclusion needs to be verified by a prospective cohort study with larger sample size and a more rigorous design.Systematic review registration[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022338503], identifier [CRD42022338503]. |
| first_indexed | 2024-04-11T11:37:07Z |
| format | Article |
| id | doaj.art-c5df5696223c41d7a647607ef14b060a |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T11:37:07Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-c5df5696223c41d7a647607ef14b060a2022-12-22T04:25:56ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-09-01910.3389/fnut.2022.972034972034Prognostic nutritional index before surgical treatment may serve as a prognostic biomarker for patients with upper tract urothelial carcinoma: A systematic review and meta-analysisChunyang Meng0Lijian Gan1Kangsen Li2Fulin Yi3Lei Peng4Jinze Li5Yunxiang Li6Department of Urology, The Affiliated Nanchong Central Hospital of North Sichuan Medical College (University), Nanchong, ChinaDepartment of Urology, The Affiliated Nanchong Central Hospital of North Sichuan Medical College (University), Nanchong, ChinaDepartment of Urology, The Affiliated Nanchong Central Hospital of North Sichuan Medical College (University), Nanchong, ChinaDepartment of Anesthesiology, North Sichuan Medical College (University), Nanchong, ChinaDepartment of Urology, The Affiliated Nanchong Central Hospital of North Sichuan Medical College (University), Nanchong, ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Urology, The Affiliated Nanchong Central Hospital of North Sichuan Medical College (University), Nanchong, ChinaObjectiveThis meta-analysis aims to assess whether the prognostic nutritional index (PNI) score before treatment can be an independent biomarker of the prognosis of patients with upper tract urothelial carcinoma (UTUC).Materials and methodsWe systematically search PubMed, Embase, Scopus database, and Cochrane Library, and the search time is up to April 2021. Use STATA 16.0 software for data processing and statistical analysis.ResultsSix studies, including seven cohorts, were eventually included in our meta-analysis. The meta-analysis results showed that low PNI scores are associated with worse OS (HR: 1.92; 95% CI 1.60 to 2.30; P < 0.01), DFS/RFS/PFS (HR: 1.57; 95% CI 1.33 to 1.85; P < 0.01), and CSS/DSS (HR: 1.79; 95% CI 1.49 to 2.16; P < 0.01), which supported the PNI score as an independent prognostic biomarker for survival outcomes. The subgroup analysis and Begg’s test showed that the results were stable.ConclusionBased on current evidence, this meta-analysis proves that the PNI score of UTUC patients before treatment is an independent prognostic biomarker. It performs well on OS, DFS/RFS/PFS, and CSS/DSS. This conclusion needs to be verified by a prospective cohort study with larger sample size and a more rigorous design.Systematic review registration[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022338503], identifier [CRD42022338503].https://www.frontiersin.org/articles/10.3389/fnut.2022.972034/fullprognostic nutritional indexupper tract urothelial carcinomaprognostic biomarkermeta-analysisPNI |
| spellingShingle | Chunyang Meng Lijian Gan Kangsen Li Fulin Yi Lei Peng Jinze Li Yunxiang Li Prognostic nutritional index before surgical treatment may serve as a prognostic biomarker for patients with upper tract urothelial carcinoma: A systematic review and meta-analysis Frontiers in Nutrition prognostic nutritional index upper tract urothelial carcinoma prognostic biomarker meta-analysis PNI |
| title | Prognostic nutritional index before surgical treatment may serve as a prognostic biomarker for patients with upper tract urothelial carcinoma: A systematic review and meta-analysis |
| title_full | Prognostic nutritional index before surgical treatment may serve as a prognostic biomarker for patients with upper tract urothelial carcinoma: A systematic review and meta-analysis |
| title_fullStr | Prognostic nutritional index before surgical treatment may serve as a prognostic biomarker for patients with upper tract urothelial carcinoma: A systematic review and meta-analysis |
| title_full_unstemmed | Prognostic nutritional index before surgical treatment may serve as a prognostic biomarker for patients with upper tract urothelial carcinoma: A systematic review and meta-analysis |
| title_short | Prognostic nutritional index before surgical treatment may serve as a prognostic biomarker for patients with upper tract urothelial carcinoma: A systematic review and meta-analysis |
| title_sort | prognostic nutritional index before surgical treatment may serve as a prognostic biomarker for patients with upper tract urothelial carcinoma a systematic review and meta analysis |
| topic | prognostic nutritional index upper tract urothelial carcinoma prognostic biomarker meta-analysis PNI |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.972034/full |
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