<i>Mycobacterium tuberculosis</i> Resides in Macrophages in Laryngeal Tuberculosis: A Case Report

Laryngeal tuberculosis is a rare form of extrapulmonary tuberculosis that questions the natural history of this infection. We report one such case in which a pathological examination of a laryngeal biopsy revealed granulomatous inflammation with caseous necrosis. Further investigations combining imm...

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Bibliographic Details
Main Authors: Wafaa Achache, Mahmoud A. Boualam, Nadim Cassir, Clémence Mimari, Delphine Poitrenaud, Soraya Mezouar, Jean Louis Mège, Michel Drancourt, Hubert Lepidi
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pathogens
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Online Access:https://www.mdpi.com/2076-0817/12/12/1413
Description
Summary:Laryngeal tuberculosis is a rare form of extrapulmonary tuberculosis that questions the natural history of this infection. We report one such case in which a pathological examination of a laryngeal biopsy revealed granulomatous inflammation with caseous necrosis. Further investigations combining immunofluorescence detection of macrophages and in situ hybridization of <i>Mycobacterium tuberculosis</i> indicated the presence of <i>Mycobacterium tuberculosis</i> (<i>M. tuberculosis</i>) in laryngeal granulomatous inflammatory lesions. This observation suggests that the natural history of laryngeal tuberculosis does not differ from that of other forms, guiding early diagnosis in patients with laryngeal lesions to ensure appropriate check-ups and treatment.
ISSN:2076-0817