Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector
Vesicular stomatitis virus (VSV), which belongs to the <i>Vesiculovirus</i> genus of the family <i>Rhabdoviridae</i>, is a well studied livestock pathogen and prototypic non-segmented, negative-sense RNA virus. Although VSV is responsible for causing economically significant...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/9/1092 |
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| author | Guodong Liu Wenguang Cao Abdjeleel Salawudeen Wenjun Zhu Karla Emeterio David Safronetz Logan Banadyga |
| author_facet | Guodong Liu Wenguang Cao Abdjeleel Salawudeen Wenjun Zhu Karla Emeterio David Safronetz Logan Banadyga |
| author_sort | Guodong Liu |
| collection | DOAJ |
| description | Vesicular stomatitis virus (VSV), which belongs to the <i>Vesiculovirus</i> genus of the family <i>Rhabdoviridae</i>, is a well studied livestock pathogen and prototypic non-segmented, negative-sense RNA virus. Although VSV is responsible for causing economically significant outbreaks of vesicular stomatitis in cattle, horses, and swine, the virus also represents a valuable research tool for molecular biologists and virologists. Indeed, the establishment of a reverse genetics system for the recovery of infectious VSV from cDNA transformed the utility of this virus and paved the way for its use as a vaccine vector. A highly effective VSV-based vaccine against Ebola virus recently received clinical approval, and many other VSV-based vaccines have been developed, particularly for high-consequence viruses. This review seeks to provide a holistic but concise overview of VSV, covering the virus’s ascension from perennial agricultural scourge to promising medical countermeasure, with a particular focus on vaccines. |
| first_indexed | 2024-03-10T07:19:37Z |
| format | Article |
| id | doaj.art-c5e2fc755c224c75b8356b3bc5310777 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T07:19:37Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-c5e2fc755c224c75b8356b3bc53107772023-11-22T14:41:35ZengMDPI AGPathogens2076-08172021-08-01109109210.3390/pathogens10091092Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine VectorGuodong Liu0Wenguang Cao1Abdjeleel Salawudeen2Wenjun Zhu3Karla Emeterio4David Safronetz5Logan Banadyga6Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, CanadaSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, CanadaDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, CanadaCanadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB R3E 3M4, CanadaSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, CanadaSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, CanadaSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, CanadaVesicular stomatitis virus (VSV), which belongs to the <i>Vesiculovirus</i> genus of the family <i>Rhabdoviridae</i>, is a well studied livestock pathogen and prototypic non-segmented, negative-sense RNA virus. Although VSV is responsible for causing economically significant outbreaks of vesicular stomatitis in cattle, horses, and swine, the virus also represents a valuable research tool for molecular biologists and virologists. Indeed, the establishment of a reverse genetics system for the recovery of infectious VSV from cDNA transformed the utility of this virus and paved the way for its use as a vaccine vector. A highly effective VSV-based vaccine against Ebola virus recently received clinical approval, and many other VSV-based vaccines have been developed, particularly for high-consequence viruses. This review seeks to provide a holistic but concise overview of VSV, covering the virus’s ascension from perennial agricultural scourge to promising medical countermeasure, with a particular focus on vaccines.https://www.mdpi.com/2076-0817/10/9/1092vesicular stomatitis virusVSVvaccinecountermeasureEbola virusVSV-EBOV |
| spellingShingle | Guodong Liu Wenguang Cao Abdjeleel Salawudeen Wenjun Zhu Karla Emeterio David Safronetz Logan Banadyga Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector Pathogens vesicular stomatitis virus VSV vaccine countermeasure Ebola virus VSV-EBOV |
| title | Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector |
| title_full | Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector |
| title_fullStr | Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector |
| title_full_unstemmed | Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector |
| title_short | Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector |
| title_sort | vesicular stomatitis virus from agricultural pathogen to vaccine vector |
| topic | vesicular stomatitis virus VSV vaccine countermeasure Ebola virus VSV-EBOV |
| url | https://www.mdpi.com/2076-0817/10/9/1092 |
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