Five-year follow-up observation of HIV prevalence in serodiscordant couples
Objectives: To evaluate the rate of HIV seroconversion and the related risk factors among HIV discordant couples in Hubei Province, China. Methods: HIV seroconversion rates and associated factors in discordant couples were identified during 2010–2012, based on existing data collected in serological...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-04-01
|
| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971215000351 |
| _version_ | 1818934873726910464 |
|---|---|
| author | Rong-rong Yang Xien Gui Yong Xiong Shi-cheng Gao Ya-jun Yan |
| author_facet | Rong-rong Yang Xien Gui Yong Xiong Shi-cheng Gao Ya-jun Yan |
| author_sort | Rong-rong Yang |
| collection | DOAJ |
| description | Objectives: To evaluate the rate of HIV seroconversion and the related risk factors among HIV discordant couples in Hubei Province, China.
Methods: HIV seroconversion rates and associated factors in discordant couples were identified during 2010–2012, based on existing data collected in serological and behavioral surveys between 2005 and 2007.
Results: At baseline, HIV transmission had occurred in 505 out of 1258 couples and the annual rate of HIV transmission was 6.3% in the absence of an intervention (40.14% after HIV exposure for 6.4 years). Five out of 753 discordant couples were found to have seroconverted during the 5-year follow-up observation after the implementation of interventions. Factors independently associated with HIV seroconversion included an HIV viral load >1000 copies/ml (odds ratio (OR) 18.706, 95% confidence interval (CI) 1.577–221.926), the index partner being on antiretroviral therapy (OR 0.019, 95% CI 0.002–0.180), and condom use in the past 6 months (OR 0.194, 95% CI 0.021–0.795).
Conclusions: HIV-negative partners in serodiscordant couples were at risk of HIV infection if the index partner did not receive any intervention. It is strongly advised that existing interventions are used, such as couples consultations, condom use, and antiretroviral treatment, to minimize the risk of HIV transmission. |
| first_indexed | 2024-12-20T05:11:12Z |
| format | Article |
| id | doaj.art-c5e3a5ec516e421f858cd5898c3fd7e0 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-20T05:11:12Z |
| publishDate | 2015-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-c5e3a5ec516e421f858cd5898c3fd7e02022-12-21T19:52:16ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112015-04-0133C17918410.1016/j.ijid.2015.02.007Five-year follow-up observation of HIV prevalence in serodiscordant couplesRong-rong YangXien GuiYong XiongShi-cheng GaoYa-jun YanObjectives: To evaluate the rate of HIV seroconversion and the related risk factors among HIV discordant couples in Hubei Province, China. Methods: HIV seroconversion rates and associated factors in discordant couples were identified during 2010–2012, based on existing data collected in serological and behavioral surveys between 2005 and 2007. Results: At baseline, HIV transmission had occurred in 505 out of 1258 couples and the annual rate of HIV transmission was 6.3% in the absence of an intervention (40.14% after HIV exposure for 6.4 years). Five out of 753 discordant couples were found to have seroconverted during the 5-year follow-up observation after the implementation of interventions. Factors independently associated with HIV seroconversion included an HIV viral load >1000 copies/ml (odds ratio (OR) 18.706, 95% confidence interval (CI) 1.577–221.926), the index partner being on antiretroviral therapy (OR 0.019, 95% CI 0.002–0.180), and condom use in the past 6 months (OR 0.194, 95% CI 0.021–0.795). Conclusions: HIV-negative partners in serodiscordant couples were at risk of HIV infection if the index partner did not receive any intervention. It is strongly advised that existing interventions are used, such as couples consultations, condom use, and antiretroviral treatment, to minimize the risk of HIV transmission.http://www.sciencedirect.com/science/article/pii/S1201971215000351HIVSerodiscordant couplesBehavioral interventionAntiretroviral therapyCondom |
| spellingShingle | Rong-rong Yang Xien Gui Yong Xiong Shi-cheng Gao Ya-jun Yan Five-year follow-up observation of HIV prevalence in serodiscordant couples International Journal of Infectious Diseases HIV Serodiscordant couples Behavioral intervention Antiretroviral therapy Condom |
| title | Five-year follow-up observation of HIV prevalence in serodiscordant couples |
| title_full | Five-year follow-up observation of HIV prevalence in serodiscordant couples |
| title_fullStr | Five-year follow-up observation of HIV prevalence in serodiscordant couples |
| title_full_unstemmed | Five-year follow-up observation of HIV prevalence in serodiscordant couples |
| title_short | Five-year follow-up observation of HIV prevalence in serodiscordant couples |
| title_sort | five year follow up observation of hiv prevalence in serodiscordant couples |
| topic | HIV Serodiscordant couples Behavioral intervention Antiretroviral therapy Condom |
| url | http://www.sciencedirect.com/science/article/pii/S1201971215000351 |
| work_keys_str_mv | AT rongrongyang fiveyearfollowupobservationofhivprevalenceinserodiscordantcouples AT xiengui fiveyearfollowupobservationofhivprevalenceinserodiscordantcouples AT yongxiong fiveyearfollowupobservationofhivprevalenceinserodiscordantcouples AT shichenggao fiveyearfollowupobservationofhivprevalenceinserodiscordantcouples AT yajunyan fiveyearfollowupobservationofhivprevalenceinserodiscordantcouples |