Use of the Fully Spectroscopic Pixelated Cadmium Telluride Detector for Benchtop X-Ray Fluorescence Computed Tomography
In this work, we integrated a commercially-available fully-spectroscopic pixelated cadmium telluride (CdTe) detector system as a two-dimensional (2D) array detector into our existing benchtop cone-beam x-ray fluorescence computed tomography (XFCT) system. After integrating this detector, known as Hi...
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| Format: | Article |
| Language: | English |
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IEEE
2022-01-01
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| Series: | IEEE Access |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/9905602/ |
| _version_ | 1817983762925879296 |
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| author | Sandun Jayarathna Hem Moktan Sang Hyun Cho |
| author_facet | Sandun Jayarathna Hem Moktan Sang Hyun Cho |
| author_sort | Sandun Jayarathna |
| collection | DOAJ |
| description | In this work, we integrated a commercially-available fully-spectroscopic pixelated cadmium telluride (CdTe) detector system as a two-dimensional (2D) array detector into our existing benchtop cone-beam x-ray fluorescence computed tomography (XFCT) system. After integrating this detector, known as High-Energy X-ray Imaging Technology (HEXITEC), we performed quantitative imaging of gold nanoparticle (GNP) distribution in a small animal-sized phantom using our benchtop XFCT system. Owing to the upgraded detector component within our benchtop XFCT system, we were able to conduct this phantom imaging in an unprecedented manner by volumetric XFCT scans followed by XFCT image reconstruction in 3D. The current results showed that adoption of HEXITEC, in conjunction with a custom-made parallel-hole collimator, drastically reduced the XFCT scan time/dose. Compared with the previous work performed with our original benchtop XFCT system adopting a single crystal CdTe detector, the currently observed reduction was up to a factor of 5, while achieving comparable GNP detection limit under similar experimental conditions. Overall, we demonstrated, for the first time to the best our knowledge, the feasibility of benchtop XFCT imaging of small animal-sized objects containing biologically relevant GNP concentrations (on the order of 0.1 mg Au/cm3 or 100 parts-per-million/ppm), with the scan time (on the order of 1 minute)/ x-ray dose (on the order of 10 cGy) that are likely meeting the minimum requirements for routine preclinical imaging applications. |
| first_indexed | 2024-04-13T23:37:27Z |
| format | Article |
| id | doaj.art-c5e3a948a8d146e590fde6f29e43bd65 |
| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-04-13T23:37:27Z |
| publishDate | 2022-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj.art-c5e3a948a8d146e590fde6f29e43bd652022-12-22T02:24:41ZengIEEEIEEE Access2169-35362022-01-011010507410508310.1109/ACCESS.2022.32105909905602Use of the Fully Spectroscopic Pixelated Cadmium Telluride Detector for Benchtop X-Ray Fluorescence Computed TomographySandun Jayarathna0Hem Moktan1Sang Hyun Cho2https://orcid.org/0000-0002-6357-5042Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USAIn this work, we integrated a commercially-available fully-spectroscopic pixelated cadmium telluride (CdTe) detector system as a two-dimensional (2D) array detector into our existing benchtop cone-beam x-ray fluorescence computed tomography (XFCT) system. After integrating this detector, known as High-Energy X-ray Imaging Technology (HEXITEC), we performed quantitative imaging of gold nanoparticle (GNP) distribution in a small animal-sized phantom using our benchtop XFCT system. Owing to the upgraded detector component within our benchtop XFCT system, we were able to conduct this phantom imaging in an unprecedented manner by volumetric XFCT scans followed by XFCT image reconstruction in 3D. The current results showed that adoption of HEXITEC, in conjunction with a custom-made parallel-hole collimator, drastically reduced the XFCT scan time/dose. Compared with the previous work performed with our original benchtop XFCT system adopting a single crystal CdTe detector, the currently observed reduction was up to a factor of 5, while achieving comparable GNP detection limit under similar experimental conditions. Overall, we demonstrated, for the first time to the best our knowledge, the feasibility of benchtop XFCT imaging of small animal-sized objects containing biologically relevant GNP concentrations (on the order of 0.1 mg Au/cm3 or 100 parts-per-million/ppm), with the scan time (on the order of 1 minute)/ x-ray dose (on the order of 10 cGy) that are likely meeting the minimum requirements for routine preclinical imaging applications.https://ieeexplore.ieee.org/document/9905602/X-ray fluorescenceX-ray fluorescence computed tomographyCdTe detectorHEXITECgold nanoparticlequantitative imaging |
| spellingShingle | Sandun Jayarathna Hem Moktan Sang Hyun Cho Use of the Fully Spectroscopic Pixelated Cadmium Telluride Detector for Benchtop X-Ray Fluorescence Computed Tomography IEEE Access X-ray fluorescence X-ray fluorescence computed tomography CdTe detector HEXITEC gold nanoparticle quantitative imaging |
| title | Use of the Fully Spectroscopic Pixelated Cadmium Telluride Detector for Benchtop X-Ray Fluorescence Computed Tomography |
| title_full | Use of the Fully Spectroscopic Pixelated Cadmium Telluride Detector for Benchtop X-Ray Fluorescence Computed Tomography |
| title_fullStr | Use of the Fully Spectroscopic Pixelated Cadmium Telluride Detector for Benchtop X-Ray Fluorescence Computed Tomography |
| title_full_unstemmed | Use of the Fully Spectroscopic Pixelated Cadmium Telluride Detector for Benchtop X-Ray Fluorescence Computed Tomography |
| title_short | Use of the Fully Spectroscopic Pixelated Cadmium Telluride Detector for Benchtop X-Ray Fluorescence Computed Tomography |
| title_sort | use of the fully spectroscopic pixelated cadmium telluride detector for benchtop x ray fluorescence computed tomography |
| topic | X-ray fluorescence X-ray fluorescence computed tomography CdTe detector HEXITEC gold nanoparticle quantitative imaging |
| url | https://ieeexplore.ieee.org/document/9905602/ |
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