Association between transcutaneous oxygen saturation within 24 h of admission and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: a retrospective analysis of the MIMIC-IV database
BackgroundIn critically ill patients, transcutaneous oxygen saturation (SpO2) upon admission is typically associated with in-hospital mortality. Nevertheless, the available information for patients with non-traumatic subarachnoid hemorrhage (SAH) is limited. In our study, our objective was to assess...
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1292260/full |
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| author | Junjie Liu Zongxu Zhao Jianmin Li Qiuhua Zhang Yichao Wang Junwei Zhang |
| author_facet | Junjie Liu Zongxu Zhao Jianmin Li Qiuhua Zhang Yichao Wang Junwei Zhang |
| author_sort | Junjie Liu |
| collection | DOAJ |
| description | BackgroundIn critically ill patients, transcutaneous oxygen saturation (SpO2) upon admission is typically associated with in-hospital mortality. Nevertheless, the available information for patients with non-traumatic subarachnoid hemorrhage (SAH) is limited. In our study, our objective was to assess the correlation between SpO2 levels and mortality among patients diagnosed with severe SAH.MethodsIn this study, we extracted data from the Medical Information Marketplace in Intensive Care (MIMIC-IV) database, which comprises information on critically ill patients. By employing matching ICD-9 and ICD-10 codes, we identified 3,328 patients diagnosed with SAH. Every individual who was admitted to the intensive care unit (ICU) had their SpO2 data and various covariates, including age, sex, diagnosis, and duration of stay, recorded upon admission. Subsequently, the patients were categorized into three distinct groups according to their SpO2 levels: low (≤95%), moderate (95–98%), and high (≥98%). To investigate the association between percutaneous oxygen saturation and mortality in patients with severe SAH, logistic regression, and cubic spline models were utilized. The main outcomes of interest were 28- and 90-day mortality rates. Additionally, subgroup analyses were conducted to evaluate these correlations and assess the consistency of interactions.ResultsA cohort of 864 patients diagnosed with non-traumatic SAH was included in this study. The correlation between SpO2 and mortality displayed a U-shaped curve when utilizing a finite cubic spline function (non-linearity < 0.001), with the nadir in the probability of in-hospital death at 96%. Mortality at 28 and 90 days showed an inverse correlation with SpO2 < 96% (adjusted odds ratio [OR], 0.8; 95% confidence interval [CI], 0.67–0.95, and 0.76; 95% CI, 0.6–0.96). Conversely, there was a positive correlation between percutaneous oxygen saturation (SpO2) levels of ≥96% and mortality rates at both 28 and 90 days (adjusted OR, 1.17; 95% CI, 1.02–1.35 and 1.2; 95% CI, 1.05–1.39).ConclusionIn patients with severe subarachnoid hemorrhage, the association between SpO2 and mortality at 28 and 90 days demonstrated a U-shaped pattern. When SpO2 levels were between 95 and 98%, both short- and long-term mortality rates were at their lowest. Patients with significant subarachnoid hemorrhage had a lower chance of survival when their SpO2 values were either high or low. |
| first_indexed | 2024-03-10T18:46:49Z |
| format | Article |
| id | doaj.art-c5e3ac11f86c4b7090ba11d2f561eee6 |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-10T18:46:49Z |
| publishDate | 2023-11-01 |
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| spelling | doaj.art-c5e3ac11f86c4b7090ba11d2f561eee62023-11-20T05:29:16ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-11-011410.3389/fneur.2023.12922601292260Association between transcutaneous oxygen saturation within 24 h of admission and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: a retrospective analysis of the MIMIC-IV databaseJunjie Liu0Zongxu Zhao1Jianmin Li2Qiuhua Zhang3Yichao Wang4Junwei Zhang5College of Clinical Medicine, North China University of Science and Technology, Tangshan, ChinaCollege of Stomatology, North China University of Science and Technology, Tangshan, ChinaDepartment of Neurosurgical Intensive Care Unit, The Affiliated Hospital, North China University of Science and Technology, Tangshan, ChinaCollege of Clinical Medicine, North China University of Science and Technology, Tangshan, ChinaCollege of Clinical Medicine, North China University of Science and Technology, Tangshan, ChinaDepartment of Neurosurgical Intensive Care Unit, The Affiliated Hospital, North China University of Science and Technology, Tangshan, ChinaBackgroundIn critically ill patients, transcutaneous oxygen saturation (SpO2) upon admission is typically associated with in-hospital mortality. Nevertheless, the available information for patients with non-traumatic subarachnoid hemorrhage (SAH) is limited. In our study, our objective was to assess the correlation between SpO2 levels and mortality among patients diagnosed with severe SAH.MethodsIn this study, we extracted data from the Medical Information Marketplace in Intensive Care (MIMIC-IV) database, which comprises information on critically ill patients. By employing matching ICD-9 and ICD-10 codes, we identified 3,328 patients diagnosed with SAH. Every individual who was admitted to the intensive care unit (ICU) had their SpO2 data and various covariates, including age, sex, diagnosis, and duration of stay, recorded upon admission. Subsequently, the patients were categorized into three distinct groups according to their SpO2 levels: low (≤95%), moderate (95–98%), and high (≥98%). To investigate the association between percutaneous oxygen saturation and mortality in patients with severe SAH, logistic regression, and cubic spline models were utilized. The main outcomes of interest were 28- and 90-day mortality rates. Additionally, subgroup analyses were conducted to evaluate these correlations and assess the consistency of interactions.ResultsA cohort of 864 patients diagnosed with non-traumatic SAH was included in this study. The correlation between SpO2 and mortality displayed a U-shaped curve when utilizing a finite cubic spline function (non-linearity < 0.001), with the nadir in the probability of in-hospital death at 96%. Mortality at 28 and 90 days showed an inverse correlation with SpO2 < 96% (adjusted odds ratio [OR], 0.8; 95% confidence interval [CI], 0.67–0.95, and 0.76; 95% CI, 0.6–0.96). Conversely, there was a positive correlation between percutaneous oxygen saturation (SpO2) levels of ≥96% and mortality rates at both 28 and 90 days (adjusted OR, 1.17; 95% CI, 1.02–1.35 and 1.2; 95% CI, 1.05–1.39).ConclusionIn patients with severe subarachnoid hemorrhage, the association between SpO2 and mortality at 28 and 90 days demonstrated a U-shaped pattern. When SpO2 levels were between 95 and 98%, both short- and long-term mortality rates were at their lowest. Patients with significant subarachnoid hemorrhage had a lower chance of survival when their SpO2 values were either high or low.https://www.frontiersin.org/articles/10.3389/fneur.2023.1292260/fulltranscutaneous oxygen saturationmortalityhypoxiahyperoxiasubarachnoid hemorrhageintensive care unit |
| spellingShingle | Junjie Liu Zongxu Zhao Jianmin Li Qiuhua Zhang Yichao Wang Junwei Zhang Association between transcutaneous oxygen saturation within 24 h of admission and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: a retrospective analysis of the MIMIC-IV database Frontiers in Neurology transcutaneous oxygen saturation mortality hypoxia hyperoxia subarachnoid hemorrhage intensive care unit |
| title | Association between transcutaneous oxygen saturation within 24 h of admission and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: a retrospective analysis of the MIMIC-IV database |
| title_full | Association between transcutaneous oxygen saturation within 24 h of admission and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: a retrospective analysis of the MIMIC-IV database |
| title_fullStr | Association between transcutaneous oxygen saturation within 24 h of admission and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: a retrospective analysis of the MIMIC-IV database |
| title_full_unstemmed | Association between transcutaneous oxygen saturation within 24 h of admission and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: a retrospective analysis of the MIMIC-IV database |
| title_short | Association between transcutaneous oxygen saturation within 24 h of admission and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: a retrospective analysis of the MIMIC-IV database |
| title_sort | association between transcutaneous oxygen saturation within 24 h of admission and mortality in critically ill patients with non traumatic subarachnoid hemorrhage a retrospective analysis of the mimic iv database |
| topic | transcutaneous oxygen saturation mortality hypoxia hyperoxia subarachnoid hemorrhage intensive care unit |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1292260/full |
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