Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance
ObjectiveThis study investigates whether volumes of intake in the first 24 h of life (24 HOL), in relation to birth weight (BW) and gestational age (GA), impact neonatal feeding intolerance (FI).MethodsThis study employed a retrospective chart review of 6,650 infants born at ≥35 weeks. The volumes o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1245947/full |
| _version_ | 1797733502972592128 |
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| author | Navin Kumar Igbagbosanmi Oredein Mohammed Al-Nahar Nathalee Harris Venkatesh Sampath |
| author_facet | Navin Kumar Igbagbosanmi Oredein Mohammed Al-Nahar Nathalee Harris Venkatesh Sampath |
| author_sort | Navin Kumar |
| collection | DOAJ |
| description | ObjectiveThis study investigates whether volumes of intake in the first 24 h of life (24 HOL), in relation to birth weight (BW) and gestational age (GA), impact neonatal feeding intolerance (FI).MethodsThis study employed a retrospective chart review of 6,650 infants born at ≥35 weeks. The volumes of each formula feed per kg BW in the first 24 HOL were assessed. FI was defined as evidenced by chart documentation of emesis, abdominal distension, abdominal x-ray, and/or switching to a sensitive formula.ResultsOverall, the maximum volume of formula intake per feed was inversely correlated with GA and was higher in infants with FI (β = −1.39, p < 0.001) compared with infants without FI (β = −1.28, p < 0.001). The odds of emesis in late preterm infants with first feeding of >8 ml/kg [adjusted odds ratio (AOR) = 2.5, 95% confidence interval (CI): 1.4–4.6] and formula switching in the exclusively formula-fed group with volumes >10.5 ml/kg [AOR = 2.2, 95% CI (1.8–2.6)] were high. In the breastfeeding group, the odds of FI increased by 2.8-, 4.6-, and 5.2-fold with 5–10, 10–15, and >15 ml/kg of supplementations, respectively.ConclusionA higher volume of intake in relation to BW often exceeds the physiological stomach capacity of newborns and is associated with early FI. Optimizing early feeding volumes based on infant BW and GA may decrease FI, which may be an issue of volume intolerance. |
| first_indexed | 2024-03-12T12:30:01Z |
| format | Article |
| id | doaj.art-c5e6326f19724783a579eff50060745d |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-12T12:30:01Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-c5e6326f19724783a579eff50060745d2023-08-29T16:22:56ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-08-011110.3389/fped.2023.12459471245947Impact of feeding volumes in the first 24 h of life on neonatal feeding intoleranceNavin Kumar0Igbagbosanmi Oredein1Mohammed Al-Nahar2Nathalee Harris3Venkatesh Sampath4Division of Neonatology, Hurley Children’s Hospital, Flint, MI, United StatesDivision of Neonatology, Hurley Children’s Hospital, Flint, MI, United StatesDivision of Neonatology, Hurley Children’s Hospital, Flint, MI, United StatesDivision of Neonatology, Hurley Children’s Hospital, Flint, MI, United StatesDivision of Neonatology, Children’s Mercy Hospital, Kansas City, MO, United StatesObjectiveThis study investigates whether volumes of intake in the first 24 h of life (24 HOL), in relation to birth weight (BW) and gestational age (GA), impact neonatal feeding intolerance (FI).MethodsThis study employed a retrospective chart review of 6,650 infants born at ≥35 weeks. The volumes of each formula feed per kg BW in the first 24 HOL were assessed. FI was defined as evidenced by chart documentation of emesis, abdominal distension, abdominal x-ray, and/or switching to a sensitive formula.ResultsOverall, the maximum volume of formula intake per feed was inversely correlated with GA and was higher in infants with FI (β = −1.39, p < 0.001) compared with infants without FI (β = −1.28, p < 0.001). The odds of emesis in late preterm infants with first feeding of >8 ml/kg [adjusted odds ratio (AOR) = 2.5, 95% confidence interval (CI): 1.4–4.6] and formula switching in the exclusively formula-fed group with volumes >10.5 ml/kg [AOR = 2.2, 95% CI (1.8–2.6)] were high. In the breastfeeding group, the odds of FI increased by 2.8-, 4.6-, and 5.2-fold with 5–10, 10–15, and >15 ml/kg of supplementations, respectively.ConclusionA higher volume of intake in relation to BW often exceeds the physiological stomach capacity of newborns and is associated with early FI. Optimizing early feeding volumes based on infant BW and GA may decrease FI, which may be an issue of volume intolerance.https://www.frontiersin.org/articles/10.3389/fped.2023.1245947/fullformula supplementationfeeding variabilityfeeding intoleranceformula switchinitial volume of feeding |
| spellingShingle | Navin Kumar Igbagbosanmi Oredein Mohammed Al-Nahar Nathalee Harris Venkatesh Sampath Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance Frontiers in Pediatrics formula supplementation feeding variability feeding intolerance formula switch initial volume of feeding |
| title | Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
| title_full | Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
| title_fullStr | Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
| title_full_unstemmed | Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
| title_short | Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
| title_sort | impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
| topic | formula supplementation feeding variability feeding intolerance formula switch initial volume of feeding |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1245947/full |
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