Increased prevalence of albuminuria in HIV-infected adults with diabetes.
HIV and type 2 diabetes are known risk factors for albuminuria, but no previous reports have characterized albuminuria in HIV-infected patients with diabetes.We performed a cross-sectional study including 73 HIV-infected adults with type 2 diabetes, 82 HIV-infected non-diabetics, and 61 diabetic con...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3172239?pdf=render |
| _version_ | 1818382599441088512 |
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| author | Peter S Kim Christian Woods Lauren Dutcher Patrick Georgoff Alice Rosenberg Jo Ann M Mican Jeffrey B Kopp Margo A Smith Colleen Hadigan |
| author_facet | Peter S Kim Christian Woods Lauren Dutcher Patrick Georgoff Alice Rosenberg Jo Ann M Mican Jeffrey B Kopp Margo A Smith Colleen Hadigan |
| author_sort | Peter S Kim |
| collection | DOAJ |
| description | HIV and type 2 diabetes are known risk factors for albuminuria, but no previous reports have characterized albuminuria in HIV-infected patients with diabetes.We performed a cross-sectional study including 73 HIV-infected adults with type 2 diabetes, 82 HIV-infected non-diabetics, and 61 diabetic control subjects without HIV. Serum creatinine >1.5 mg/dL was exclusionary. Albuminuria was defined as urinary albumin/creatinine ratio >30 mg/g.The prevalence of albuminuria was significantly increased among HIV-infected diabetics (34% vs. 13% of HIV non-diabetic vs. 16% diabetic control, p = 0.005). HIV status and diabetes remained significant predictors of albuminuria after adjusting for age, race, BMI, and blood pressure. Albumin/creatinine ratio correlated significantly with HIV viral load (r = 0.28, p = 0.0005) and HIV-infected subjects with albuminuria had significantly greater cumulative exposure to abacavir (p = 0.01). In an adjusted multivariate regression analysis of HIV-infected subjects, the diagnosis of diabetes (p = 0.003), higher HIV viral load (p = 0.03) and cumulative exposure to abacavir (p = 0.0009) were significant independent predictors of albuminuria.HIV and diabetes appear to have additive effects on albuminuria which is also independently associated with increased exposure to abacavir and HIV viral load. Future research on the persistence, progression and management of albuminuria in this unique at-risk population is needed. |
| first_indexed | 2024-12-14T02:53:02Z |
| format | Article |
| id | doaj.art-c5e6b16e04cc43a5aedfadd08fdb00a2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T02:53:02Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c5e6b16e04cc43a5aedfadd08fdb00a22022-12-21T23:19:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0169e2461010.1371/journal.pone.0024610Increased prevalence of albuminuria in HIV-infected adults with diabetes.Peter S KimChristian WoodsLauren DutcherPatrick GeorgoffAlice RosenbergJo Ann M MicanJeffrey B KoppMargo A SmithColleen HadiganHIV and type 2 diabetes are known risk factors for albuminuria, but no previous reports have characterized albuminuria in HIV-infected patients with diabetes.We performed a cross-sectional study including 73 HIV-infected adults with type 2 diabetes, 82 HIV-infected non-diabetics, and 61 diabetic control subjects without HIV. Serum creatinine >1.5 mg/dL was exclusionary. Albuminuria was defined as urinary albumin/creatinine ratio >30 mg/g.The prevalence of albuminuria was significantly increased among HIV-infected diabetics (34% vs. 13% of HIV non-diabetic vs. 16% diabetic control, p = 0.005). HIV status and diabetes remained significant predictors of albuminuria after adjusting for age, race, BMI, and blood pressure. Albumin/creatinine ratio correlated significantly with HIV viral load (r = 0.28, p = 0.0005) and HIV-infected subjects with albuminuria had significantly greater cumulative exposure to abacavir (p = 0.01). In an adjusted multivariate regression analysis of HIV-infected subjects, the diagnosis of diabetes (p = 0.003), higher HIV viral load (p = 0.03) and cumulative exposure to abacavir (p = 0.0009) were significant independent predictors of albuminuria.HIV and diabetes appear to have additive effects on albuminuria which is also independently associated with increased exposure to abacavir and HIV viral load. Future research on the persistence, progression and management of albuminuria in this unique at-risk population is needed.http://europepmc.org/articles/PMC3172239?pdf=render |
| spellingShingle | Peter S Kim Christian Woods Lauren Dutcher Patrick Georgoff Alice Rosenberg Jo Ann M Mican Jeffrey B Kopp Margo A Smith Colleen Hadigan Increased prevalence of albuminuria in HIV-infected adults with diabetes. PLoS ONE |
| title | Increased prevalence of albuminuria in HIV-infected adults with diabetes. |
| title_full | Increased prevalence of albuminuria in HIV-infected adults with diabetes. |
| title_fullStr | Increased prevalence of albuminuria in HIV-infected adults with diabetes. |
| title_full_unstemmed | Increased prevalence of albuminuria in HIV-infected adults with diabetes. |
| title_short | Increased prevalence of albuminuria in HIV-infected adults with diabetes. |
| title_sort | increased prevalence of albuminuria in hiv infected adults with diabetes |
| url | http://europepmc.org/articles/PMC3172239?pdf=render |
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